Füsioloogia osakonna publikatsioonid ja patendid

08.02.2022
#teadus

 

  • Loite U, Raam L, Reimann E, Reemann P, Prans E, Traks T, Vasar E, Silm H, Kingo K, Kõks S. The Expression Pattern of Genes Related to Melanogenesis and Endogenous Opioids in Psoriasis. Int J Mol Sci. 2021 Dec 2;22(23):13056. doi: 10.3390/ijms222313056. PMID: 34884858; PMCID: PMC8657874.
  • Jagomäe T, Seppa K, Reimets R, Pastak M, Plaas M, Hickey MA, Kukker KG, Moons L, De Groef L, Vasar E, Kaasik A, Terasmaa A, Plaas M. Early Intervention and Lifelong Treatment with GLP1 Receptor Agonist Liraglutide in a Wolfram Syndrome Rat Model with an Emphasis on Visual Neurodegeneration, Sensorineural Hearing Loss and Diabetic Phenotype. Cells. 2021 Nov 16;10(11):3193. doi: 10.3390/cells10113193. PMID: 34831417; PMCID: PMC8623088.
  • Punapart M, Seppa K, Jagomäe T, Liiv M, Reimets R, Kirillov S, Kaasik A, Moons L, De Groef L, Terasmaa A, Vasar E, Plaas M. The Expression of RAAS Key Receptors, Agtr2 and Bdkrb1, Is Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome. Genes (Basel). 2021 Oct 28;12(11):1717. doi: 10.3390/genes12111717. PMID: 34828323; PMCID: PMC8621801.
  • Kaare M, Mikheim K, Lilleväli K, Kilk K, Jagomäe T, Leidmaa E, Piirsalu M, Porosk R, Singh K, Reimets R, Taalberg E, Schäfer MKE, Plaas M, Vasar E, Philips MA. High-Fat Diet Induces Pre-Diabetes and Distinct Sex-Specific Metabolic Alterations in Negr1-Deficient Mice. Biomedicines. 2021 Sep 3;9(9):1148. doi: 10.3390/biomedicines9091148. PMID: 34572334; PMCID: PMC8466019.
  • Yan L, Gu MQ, Yang ZY, Xia J, Li P, Vasar E, Tian L, Song C. Endogenous n-3 PUFAs attenuated olfactory bulbectomy-induced behavioral and metabolomic abnormalities in Fat-1 mice. Brain Behav Immun. 2021 Aug;96:143-153. doi: 10.1016/j.bbi.2021.05.024. Epub 2021 May 27. PMID: 34052364.
  • Jagomäe T, Singh K, Philips MA, Jayaram M, Seppa K, Tekko T, Gilbert SF, Vasar E, Lilleväli K. Alternative Promoter Use Governs the Expression of IgLON Cell Adhesion Molecules in Histogenetic Fields of the Embryonic Mouse Brain. Int J Mol Sci. 2021 Jun 28;22(13):6955. doi: 10.3390/ijms22136955. PMID: 34203377; PMCID: PMC8268470.
  • Heinla K, Vasar E, Sedman T, Volke V. A GLP-1 Receptor Agonist Inhibits Aldosterone Release in Healthy Volunteers. Horm Metab Res. 2021 Jun;53(6):402-407. doi: 10.1055/a-1498-7098. Epub 2021 Jun 21. PMID: 34154031.
  • Varul J, Eskla KL, Piirsalu M, Innos J, Philips MA, Visnapuu T, Plaas M, Vasar E. Dopamine System, NMDA Receptor and EGF Family Expressions in Brain Structures of Bl6 and 129Sv Strains Displaying Different Behavioral Adaptation. Brain Sci. 2021 May 29;11(6):725. doi: 10.3390/brainsci11060725. PMID: 34072341; PMCID: PMC8227283.
  • Hade AC, Philips MA, Reimann E, Jagomäe T, Eskla KL, Traks T, Prans E, Kõks S, Vasar E, Väli M. Chronic Alcohol Use Induces Molecular Genetic Changes in the Dorsomedial Thalamus of People with Alcohol-Related Disorders. Brain Sci. 2021 Mar 29;11(4):435. doi: 10.3390/brainsci11040435. PMID: 33805312; PMCID: PMC8066746.
  • Vanaveski T, Molchanova S, Pham DD, Schäfer A, Pajanoja C, Narvik J, Srinivasan V, Urb M, Koivisto M, Vasar E, Timmusk T, Minkeviciene R, Eriksson O, Lalowski M, Taira T, Korhonen L, Voikar V, Lindholm D. PGC-1α Signaling Increases GABA(A) Receptor Subunit α2 Expression, GABAergic Neurotransmission and Anxiety-Like Behavior in Mice. Front Mol Neurosci. 2021 Feb 1;14:588230. doi: 10.3389/fnmol.2021.588230. PMID: 33597848; PMCID: PMC7882546.
  • Seppa K, Jagomäe T, Kukker KG, Reimets R, Pastak M, Vasar E, Terasmaa A, Plaas M. Liraglutide, 7,8-DHF and their co-treatment prevents loss of vision and cognitive decline in a Wolfram syndrome rat model. Sci Rep. 2021 Jan 26;11(1):2275. doi: 10.1038/s41598-021-81768-6. PMID: 33500541; PMCID: PMC7838169.
  • Bregin A, Kaare M, Jagomäe T, Karis K, Singh K, Laugus K, Innos J, Leidmaa E, Heinla I, Visnapuu T, Oja EM, Kõiv K, Lilleväli K, Harro J, Philips MA, Vasar E. Expression and impact of Lsamp neural adhesion molecule in the serotonergic neurotransmission system. Pharmacol Biochem Behav. 2020 Nov;198:173017. doi: 10.1016/j.pbb.2020.173017. Epub 2020 Aug 20. PMID: 32828972.
  • Sedman T, Krass M, Rünkorg K, Vasar E, Volke V. Tolerance develops toward GLP-1 receptor agonists' glucose-lowering effect in mice. Eur J Pharmacol. 2020 Oct 15;885:173443. doi: 10.1016/j.ejphar.2020.173443. Epub 2020 Aug 1. PMID: 32750365.
  • Parksepp M, Leppik L, Koch K, Uppin K, Kangro R, Haring L, Vasar E, Zilmer M. Metabolomics approach revealed robust changes in amino acid and biogenic amine signatures in patients with schizophrenia in the early course of the disease. Sci Rep. 2020 Aug 19;10(1):13983. doi: 10.1038/s41598-020-71014-w. PMID: 32814830; PMCID: PMC7438522.
  • Piirsalu M, Taalberg E, Lilleväli K, Tian L, Zilmer M, Vasar E. Treatment With Lipopolysaccharide Induces Distinct Changes in Metabolite Profile and Body Weight in 129Sv and Bl6 Mouse Strains. Front Pharmacol. 2020 Mar 27;11:371. doi: 10.3389/fphar.2020.00371. PMID: 32292347; PMCID: PMC7118216.
  • Leppik L, Parksepp M, Janno S, Koido K, Haring L, Vasar E, Zilmer M. Profiling of lipidomics before and after antipsychotic treatment in first- episode psychosis. Eur Arch Psychiatry Clin Neurosci. 2020 Feb;270(1):59-70. doi: 10.1007/s00406-018-0971-6. Epub 2019 Jan 2. PMID: 30604052.
  • Seppa K, Toots M, Reimets R, Jagomäe T, Koppel T, Pallase M, Hasselholt S, Krogsbæk Mikkelsen M, Randel Nyengaard J, Vasar E, Terasmaa A, Plaas M. GLP-1 receptor agonist liraglutide has a neuroprotective effect on an aged rat model of Wolfram syndrome. Sci Rep. 2019 Oct 31;9(1):15742. doi: 10.1038/s41598-019-52295-2. PMID: 31673100; PMCID: PMC6823542.
  • Bregin A, Mazitov T, Aug I, Philips MA, Innos J, Vasar E. Increased sensitivity to psychostimulants and GABAergic drugs in Lsamp-deficient mice. Pharmacol Biochem Behav. 2019 Aug;183:87-97. doi: 10.1016/j.pbb.2019.05.010. Epub 2019 Jun 1. PMID: 31163180.
  • Singh K, Jayaram M, Kaare M, Leidmaa E, Jagomäe T, Heinla I, Hickey MA, Kaasik A, Schäfer MK, Innos J, Lilleväli K, Philips MA, Vasar E. Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders. Sci Rep. 2019 Apr 1;9(1):5457. doi: 10.1038/s41598-019-41991-8. PMID: 30932003; PMCID: PMC6443666.
  • Demin KA, Sysoev M, Chernysh MV, Savva AK, Koshiba M, Wappler-Guzzetta EA, Song C, De Abreu MS, Leonard B, Parker MO, Harvey BH, Tian L, Vasar E, Strekalova T, Amstislavskaya TG, Volgin AD, Alpyshov ET, Wang D, Kalueff AV. Animal models of major depressive disorder and the implications for drug discovery and development. Expert Opin Drug Discov. 2019 Apr;14(4):365-378. doi: 10.1080/17460441.2019.1575360. Epub 2019 Feb 22. PMID: 30793996.
  • Traks T, Keermann M, Karelson M, Rätsep R, Reimann E, Silm H, Vasar E, Kõks S, Kingo K. Polymorphisms in Corticotrophin-releasing Hormone- proopiomelanocortin (CRH-POMC) System Genes are Associated with Plaque Psoriasis. Acta Derm Venereol. 2019 Apr 1;99(4):444-445. doi: 10.2340/00015555-3137. PMID: 30723871.
  • Toots M, Reimets R, Plaas M, Vasar E. Muscarinic Agonist Ameliorates Insulin Secretion in Wfs1-Deficient Mice. Can J Diabetes. 2019 Mar;43(2):115-120. doi: 10.1016/j.jcjd.2018.06.007. Epub 2018 Jun 23. PMID: 30266217.
  • Balõtšev R, Haring L, Koido K, Leping V, Kriisa K, Zilmer M, Vasar V, Piir A, Lang A, Vasar E. Antipsychotic treatment is associated with inflammatory and metabolic biomarkers alterations among first-episode psychosis patients: A 7-month follow-up study. Early Interv Psychiatry. 2019 Feb;13(1):101-109. doi: 10.1111/eip.12457. Epub 2017 Jul 18. PMID: 28719155.
  • Toots M, Seppa K, Jagomäe T, Koppel T, Pallase M, Heinla I, Terasmaa A, Plaas M, Vasar E. Preventive treatment with liraglutide protects against development of glucose intolerance in a rat model of Wolfram syndrome. Sci Rep. 2018 Jul 5;8(1):10183. doi: 10.1038/s41598-018-28314-z. PMID: 29976929; PMCID:PMC6033861.
  • Vanaveski T, Narvik J, Innos J, Philips MA, Ottas A, Plaas M, Haring L, Zilmer M, Vasar E. Repeated Administration of D-Amphetamine Induces Distinct Alterations in Behavior and Metabolite Levels in 129Sv and Bl6 Mouse Strains. Front Neurosci. 2018 Jun 12;12:399. doi: 10.3389/fnins.2018.00399. PMID: 29946233; PMCID: PMC6005828.
  • Eskla KL, Porosk R, Reimets R, Visnapuu T, Vasar E, Hundahl CA, Luuk H. Hypothermia augments stress response in mammalian cells. Free Radic Biol Med. 2018 Jun;121:157-168. doi: 10.1016/j.freeradbiomed.2018.04.571. Epub 2018 Apr 25. PMID: 29704622.
  • Singh K, Lilleväli K, Gilbert SF, Bregin A, Narvik J, Jayaram M, Rahi M, Innos J, Kaasik A, Vasar E, Philips MA. The combined impact of IgLON family proteins Lsamp and Neurotrimin on developing neurons and behavioral profiles in mouse. Brain Res Bull. 2018 Jun;140:5-18. doi: 10.1016/j.brainresbull.2018.03.013. Epub 2018 Mar 29. PMID: 29605488.
  • Heinla I, Åhlgren J, Vasar E, Voikar V. Behavioural characterization of C57BL/6N and BALB/c female mice in social home cage - Effect of mixed housing in complex environment. Physiol Behav. 2018 May 1;188:32-41. doi: 10.1016/j.physbeh.2018.01.024. Epub 2018 Jan 31. PMID: 29382562.
  • Leppik L, Kriisa K, Koido K, Koch K, Kajalaid K, Haring L, Vasar E, Zilmer M. Profiling of Amino Acids and Their Derivatives Biogenic Amines Before and After Antipsychotic Treatment in First-Episode Psychosis. Front Psychiatry. 2018 Apr 24;9:155. doi: 10.3389/fpsyt.2018.00155. PMID: 29740359; PMCID: PMC5928450.
  • Narvik J, Vanaveski T, Innos J, Philips MA, Ottas A, Haring L, Zilmer M, Vasar E. Metabolic profile associated with distinct behavioral coping strategies of 129Sv and Bl6 mice in repeated motility test. Sci Rep. 2018 Feb 21;8(1):3405. doi: 10.1038/s41598-018-21752-9. PMID: 29467440; PMCID: PMC5821849.
  • Singh K, Loreth D, Pöttker B, Hefti K, Innos J, Schwald K, Hengstler H, Menzel L, Sommer CJ, Radyushkin K, Kretz O, Philips MA, Haas CA, Frauenknecht K, Lilleväli K, Heimrich B, Vasar E, Schäfer MKE. Neuronal Growth and Behavioral Alterations in Mice Deficient for the Psychiatric Disease-Associated Negr1 Gene. Front Mol Neurosci. 2018 Feb 9;11:30. doi: 10.3389/fnmol.2018.00030. PMID: 29479305; PMCID: PMC5811522.
  • Karis K, Eskla KL, Kaare M, Täht K, Tuusov J, Visnapuu T, Innos J, Jayaram M, Timmusk T, Weickert CS, Väli M, Vasar E, Philips MA. Altered Expression Profile of IgLON Family of Neural Cell Adhesion Molecules in the Dorsolateral Prefrontal Cortex of Schizophrenic Patients. Front Mol Neurosci. 2018 Jan 29;11:8. doi: 10.3389/fnmol.2018.00008. PMID: 29434535; PMCID: PMC5797424.
  • Kriisa K, Leppik L, Balõtšev R, Ottas A, Soomets U, Koido K, Volke V, Innos J, Haring L, Vasar E, Zilmer M. Profiling of Acylcarnitines in First Episode Psychosis before and after Antipsychotic Treatment. J Proteome Res. 2017 Oct 6;16(10):3558-3566. doi: 10.1021/acs.jproteome.7b00279. Epub 2017 Aug 24. PMID: 28786289.
  • Plaas M, Seppa K, Reimets R, Jagomäe T, Toots M, Koppel T, Vallisoo T, Nigul M, Heinla I, Meier R, Kaasik A, Piirsoo A, Hickey MA, Terasmaa A, Vasar E. Wfs1- deficient rats develop primary symptoms of Wolfram syndrome: insulin-dependent diabetes, optic nerve atrophy and medullary degeneration. Sci Rep. 2017 Aug 31;7(1):10220. doi: 10.1038/s41598-017-09392-x. PMID: 28860598; PMCID: PMC5579261.
  • Sedman T, Vasar E, Volke V. Tolerance Does Not Develop Toward Liraglutide's Glucose-Lowering Effect. J Clin Endocrinol Metab. 2017 Jul 1;102(7):2335-2339. doi: 10.1210/jc.2017-00199. PMID: 28379427.
  • Haring L, Mõttus R, Kajalaid K, Koch K, Uppin K, Maron E, Vasar E. The course of cognitive functioning after first-episode of psychosis: A six month follow-up study. Schizophr Res. 2017 Apr;182:31-41. doi: 10.1016/j.schres.2016.10.017. Epub 2016 Oct 13. PMID: 27746055.
  • Reemann P, Reimann E, Ilmjärv S, Porosaar O, Silm H, Jaks V, Vasar E, Kingo K, Kõks S. Correction: Melanocytes in the Skin - Comparative Whole Transcriptome Analysis of Main Skin Cell Types. PLoS One. 2017 Mar 7;12(3):e0173792. doi: 10.1371/journal.pone.0173792. Erratum for: PLoS One. 2014 Dec 29;9(12):e115717. PMID: 28267805; PMCID: PMC5340379.
  • Tekko T, Lakspere T, Allikalt A, End J, Kõlvart KR, Jagomäe T, Terasmaa A, Philips MA, Visnapuu T, Väärtnõu F, Gilbert SF, Rinken A, Vasar E, Lilleväli K. Wfs1 is expressed in dopaminoceptive regions of the amniote brain and modulates levels of D1-like receptors. PLoS One. 2017 Mar 7;12(3):e0172825. doi: 10.1371/journal.pone.0172825. PMID: 28267787; PMCID: PMC5436468.
  • Vanaveski T, Singh K, Narvik J, Eskla KL, Visnapuu T, Heinla I, Jayaram M, Innos J, Lilleväli K, Philips MA, Vasar E. Promoter-Specific Expression and Genomic Structure of IgLON Family Genes in Mouse. Front Neurosci. 2017 Feb 2;11:38. doi: 10.3389/fnins.2017.00038. PMID: 28210208; PMCID: PMC5288359.
  • Transgenic animal model for modelling pathological anxiety, a method for identifying compounds for treatment of diseases or disorders caused by pathological anxiety and a method for using wfsl protein as a target for identifying effective compounds against pathological anxiety; Owners: University of Tartu; Authors: Eero Vasar, Sulev Kõks, Hendrik Luuk, Sirli Raud, Mario Plaas; Priority number: P200600039; Priority date: 12.12.2006.