teadus

Mikrobioloogia osakonna publikatsioonid ja patendid

2025

  • Mikelsaar M, Songisepp E, Mändar, R. Teaduspõhiselt probiootikumidest: kas innovatiivsus on jõudnud probiootikumide rakendamiseni? Eesti Arst, 2025, 104 (3), 145−157.
  • Molina, NM, Canha-Gouveia A, Leones-Banos I, Sola-Leyva A, Vargas E, Ruiz-Duran S, Tenorio C, Clavero-Gilabert A, Mändar R, Altmäe S. The complementary seminovaginal microbiome in health and disease. Reproductive BioMedicine Online, 2025, 50 (5), ARTN 104707. DOI: 10.1016/j.rbmo.2024.104707.
  • Mändar R, Smidt I, Rööp T, Hoidmets D, Kilk K, Zilmer M, Ausmees K, Salumets A. Development of probiotics for male reproductive tract health: in vitro experiments and clinical trial on healthy volunteers. Andrologia. 2025(1):000428. doi:10.1155/and/7000428.
  • Naaber P, Ivanova M. Uued hingamis- ja kuseteede infektsioonide juhendid. Eesti Laborimeditsiin. 2025;11:30–32.
  • Naaber P, Sepp E. Mikrobioota ja selle mõju tervisele. Perearst. 2025;Aprill:41–44.
  • Peterson C, Tagoma A, Alnek K, Bärenson A, Vorobjova T, Talja I, Janson H, Kirss A, Kõljalg S, Sinkkonen A, Roslund MI, Uibo R, HEDIMED Investigator group. Antibodies against Clostridium butyricum in the children of mothers at risk for gestational diabetes. Immunol Med. 2025. doi:10.1080/25785826.2025.2504021.
  • Šablinskaja A, Soeorg H, Pauskar M, Jõgeda EL, Rajasaar H, Soodla P, Kallas E, Hensen K, Tabri J, Rüütel K, Päll T, Lutsar I, Huik K, Avi R. Transmitted HIV-1 drug resistance in Estonian residents and Ukrainian refugees in 2020 and 2022. J Glob Antimicrob Resist. 2025;41:258–265. doi:10.1016/j.jgar.2025.01.008.
  • Štšepetova J, Šebunova N, Voor T, Soeorg H, Rätsep M, Mändar R, Mikelsaar M, Sepp E. Quantitative differences in the human intestinal microbiota through the stages of life: infants, children, adults and the elderly. Microbiol Res. 2025;16(3):60. doi:10.3390/microbiolres16030060.
  • Vorobjova T, Tagoma A, Peterson C, Talja I, Bärenson A, Alnek K, Janson H, Metsküla K, Kirss A, Sepp E, Rööp T, Kõljalg S, Uibo R; HEDIMED Investigator group. The level of I-FABP and IgA/IgG to beta-lactoglobulin in mothers at risk for gestational diabetes and in their children: association with antibodies to Bifidobacterium adolescentis and Bifidobacterium breve. Front Immunol. 2025. doi:10.3389/fimmu.2025.1613002.
  • Hleyhel M, Geller J, Sadou A, Naaber P, Kuznetsova T, Vorobjov S, et al. Prevalence of chronic hepatitis C infection in the general population: results from a national survey, Estonia, July to December 2022. Euro Surveill. 2024;29(30):2300651. doi:10.2807/1560-7917.ES.2024.29.30.2300651.
  • Kalamees R, Soeorg H, Ilmoja ML, Margus K, Lutsar I, Metsvaht T. Prospective validation of a model-informed precision dosing tool for vancomycin treatment in neonates. Antimicrob Agents Chemother. 2024. doi:10.1128/aac.01591-23.
  • Koshovyi O, Komisarenko M, Osolodchenko T, Komissarenko A, Mändar R, Kõljalg S, et al. Eucalypt extracts prepared by a no-waste method and their 3D-printed dosage forms show antimicrobial and anti-inflammatory activity. Plants. 2024;13(6):2–20. doi:10.3390/plants13060754.
  • Lass J, Leroux S, Kõrgvee LT, Varendi H, Kipper K, Takkis K, Aro R, Metsvaht T, Oselin K, Pfister M, Soeorg H, van den Anker J, Lutsar I. Pharmacokinetics of oral spironolactone in infants up to 2 years of age. Eur J Clin Pharmacol. 2024;80(2):239–248. doi:10.1007/s00228-023-03599-w.
  • Lingasamy P, Modhukur V, Mändar R, Salumets A. Exploring immunome and microbiome interplay in reproductive health: current knowledge, challenges, and novel diagnostic tools. Semin Reprod Med. 2024;41(5). doi:10.1055/s-0043-1778017.
  • Mitt P, Ivanova M, Oona M, Saare L, Tamm E, Telling K, Tähiste JA, Naaber P. Sagedasemate hingamis- ja kuseteede infektsioonide ambulatoorne diagnostika ja ravi. Eesti Arst. 2024;103(11):581–585.
  • Mutli E, Mändar R, Koort K, Salumets A, Estonian Biobank Research Team, Laisk T. Genome-wide association study in Estonia reveals importance of vaginal epithelium associated genes in case of recurrent vaginitis. J Reprod Immunol. 2024;162:104216. doi:10.1016/j.jri.2024.104216.
  • Mändar R, Saar M, Vaikjärv R, Parm Ü, Kasenõmm P, Kõljalg S, et al. Unveiling the aetiology of peritonsillar abscess using next-generation sequencing. CMI Commun. 2024;1(Suppl):765.
  • Naaber P, Oona M. Sagedasemate hingamis- ja kuseteede infektsioonide ambulatoorne diagnostika ja ravi. Perearst. 2024;04:33–37.
  • Nguyen ATC, Nguyen NTL, Tran TTQ, Nguyen TT, Hoang TTA, Tran LM, Tran KT, Phan TDC, Nguyen XT, Le TM, Le AV, Salumets A, Mändar R. Prevalence and associated factors of bacterial vaginosis among pregnant women in Hue, Vietnam. J Infect Dev Ctries. 2024;18(6):925–931. doi:10.3855/jidc.18949.
  • Peterson C, Tagoma A, Alnek K, Bärenson A, Vorobjova T, Talja I, Janson H, Kirss A, Kõljalg S, Sinkkonen A, Roslund MI, Uibo R. Clostridium butyricum’i IgA- ja IgG-tüüpi antikehade reaktiivsus gestatsioonidiabeediga emade lastel: seosed allergiliste haiguste diagnoosidega. Eesti Arst. 2024;103(Suppl 1):26.
  • Päll T, Abroi A, Avi R, Niglas H, Shablinskaja A, Pauskar M, et al. SARS-CoV-2 clade dynamics and their associations with hospitalisations during the first two years of the COVID-19 pandemic. PLoS One. 2024;19(5):e0303176. doi:10.1371/journal.pone.0303176.
  • Soeorg H, Abroi A, Päll T, Dotsenko L, Jaaniso E, Kaarna K, et al. Dynamics of SARS-CoV-2 lineages in children and adults in 2021 and 2022. PLoS One. 2024;19(12):e0316213. doi:10.1371/journal.pone.0316213.
  • Soeorg H, Padari H, Ilmoja ML, Herodes K, Kipper K, Lutsar I, et al. Prediction of C-reactive protein dynamics during meropenem treatment in neonates and infants. Br J Clin Pharmacol. 2024;90(3):801–811. doi:10.1111/bcp.15950.
  • Tenson T, Telling K, Mitt P, Sepp E, Naaber P, Lass J, et al. Antibiotic resistance spread and resistance control options. Estonian experience. In: Antibiotic Resistance Spread and Resistance Control Options. Estonian Experience. 2024. doi:10.1101/2024.04.02.24304316.
  • Ciesielski TH, Zhang X, Tacconelli A, Lutsar I, de Cabre VM, Roilides E, et al. Late-onset neonatal sepsis: genetic differences by sex and involvement of the NOTCH pathway. Pediatr Res. 2023;93(4). doi:10.1038/s41390-022-02114-8.
  • Koort K, Sõsa K, Türk S, Lapp E, Talving E, Karits P, Haldre K, Rosenstein K, Jaagura M, Sekavin A, Sõritsa D, Karro H, Korrovits P, Salumets A, Mändar R. Lactobacillus crispatus-dominated vaginal microbiome and Acinetobacter-dominated seminal microbiome support beneficial ART outcome. Acta Obstet Gynecol Scand. 2023;102(7):921–934. doi:10.1111/aogs.14598.
  • Lõivukene K, Kermes K, Randoja R, Kõljalg S, Kaljurand K. Silmamaterjalidest isoleeritud mikroobide ja viiruste spekter ning ravimitundlikkus Tartu Ülikooli Kliinikumi silmakliinikus 2017 kuni 2021. Eesti Arst, 2023, 102 (1), 10−17. DOI: 10.15157/ea.vi.22267.
  • Kõljalg S, Naaber P, Lõivukene K, Kermes K, Allik M, Sepp E. Streptococcus pyogenes’e esinemissageduse oluline tõus. Eesti Arst, 2023, 102, Lisa 1. OÜ Celsius Healthcare, 65−65.
  • Lisco A, Lange C, Manion M, Kuriakose S, Dewar R, Gorelick RJ, Huik K, Yu Q, Hammoud DA, Smith BR, Muranski P, Rehm C, Sherman BT, Sykes C, Lindo N, Ye P, Bricker KM, Keele BF, Fennessey CM, Maldarelli F, Sereti I. Immune reconstitution inflammatory syndrome drives emergence of HIV drug resistance from multiple anatomic compartments in a person living with HIV. Nat Med. 2023;29(6):1364–1369. doi:10.1038/s41591-023-02387-4.
  • Lõivukene K, Kermes K, Sepp E, Naaber P, Mändar R, Kõljalg S. Trends in the prevalence and antibiotic susceptibility of anaerobic Gram-negative bacteria causing clinical infections in Estonia. Sri Lankan J Infect Dis. 2023;13(1):29. doi:10.4038/sljid.v13i1.8494.
  • Mändar R, Sõerunurk G, Štšepetova J, Smidt I, Rööp T, Kõljalg S, et al. Impact of Lactobacillus crispatus-containing oral and vaginal probiotics on vaginal health: a randomized double-blind placebo controlled clinical trial. Benef Microbes. 2023;14(2):143–152. doi:10.3920/BM2022.0091.
  • Naaber P, Tserel L, Kangro K, Punapart M, Sepp E, Jürgenson V, et al. Koroonaviiruse omikrontüve vastane antikehade kaitse ja T-rakuline immuunvastus pärast BNT162b2-vaktsiini tõhustusdoosi saamist. Eesti Arst. 2023;102(2):115. doi:10.15157/ea.vi.22332.
  • Naaber P, Mitt P, Telling K, Ivanova M, Lätt A, Oona M, Lass J, Tähiste JA, Tamm E, Mägi M. Sagedasemate hingamis- ja kuseteede infektsioonide ambulatoorne diagnostika ja ravi. Eesti ravijuhend, 2023, RJ-B/73.1-2023. 1−72.
  • Pärna K, Nygård M, Tisler A, Toompere K, Naaber P, Ratnik K, et al. Age-specific and genotype-specific carcinogenic human papillomavirus prevalence in a country with a high cervical cancer burden: results of a cross-sectional study in Estonia. BMJ Open. 2023;13(6):e069558. doi:10.1136/bmjopen-2022-069558.
  • Saar M, Vaikjärv R, Parm Ü, Kasenõmm P, Kõljalg S, Sepp E, et al. Unveiling the etiology of peritonsillar abscess using next generation sequencing. Ann Clin Microbiol Antimicrob. 2023;22(1):98. doi:10.1186/s12941-023-00649-0.
  • Šablinskaja A, Pauskar M, Jõgeda EL, Rajasaar H, Soodla P, Kallas E, et al. No transmitted drug resistance to HIV integrase strand-transfer inhibitors after their scale-up in Estonia in 2017. J Glob Antimicrob Resist. 2023;33. doi:10.1016/j.jgar.2023.02.009.
  • Tang BH, Zhang JY, Allegaert K, Hao GX, Yao BF, Leroux S, Lutsar I, et al. Use of machine learning for dosage individualization of vancomycin in neonates. Clin Pharmacokinet. 2023;62(8):1105–1116. doi:10.1007/s40262-023-01265-z.
  • Uusküla A, Pisarev H, Tisler A, Meister T, Suija K, Huik K, et al. Risk of SARS-CoV-2 infection and hospitalization in individuals with natural, vaccine-induced and hybrid immunity: a retrospective population-based cohort study from Estonia. Sci Rep. 2023;13(1):20347. doi:10.1038/s41598-023-47043-6.
  • Wattier RL, Bucayu RFT, Boge CLK, Ross RK, Yildirim I, Zaoutis TE, Palazzi DL, Vora SB, Castagnola E, Avilés-Robles M, Danziger-Isakov L, Tribble AC, Sharma TS, Arrieta AC, Maron G, Berman DM, Yin DE, Sung L, Green M, Roilides E, Belani K, Romero J, Soler-Palacin P, López-Medina E, Nolt D, Bin Hussain IZ, Muller WJ, Hauger SB, Halasa N, Dulek D, Pong A, Gonzalez BE, Abzug MJ, Carlesse F, Huppler AR, Rajan S, Aftandilian C, Ardura MI, Chakrabarti A, Hanisch B, Salvatore CM, Klingspor L, Knackstedt ED, Lutsar I, Santolaya ME, Shuster S, Johnson SK, Steinbach WJ, Fisher BT. Adjunctive diagnostic studies completed following detection of candidemia in children: secondary analysis of observed practice from a multicenter cohort study conducted by the Pediatric Fungal Network. J Pediatric Infect Dis Soc. 2023;12(9):487–495. doi:10.1093/jpids/piad057.
  • Abroi A, Gerst Talas U, Pauskar M, Shablinskaja A, Reisberg T, Niglas H, Päll T, Nelis M, Tagen I, Soodla P, Lutsar I, Huik K. SARS-CoV-2 dual infection with Delta and Omicron variants in an immunocompetent host: a case report. Int J Infect Dis. 2022;124:41–44. doi:10.1016/j.ijid.2022.08.027.
  • Cook A, Sharland M, Yau Y, Group P, Bielicki J; PediBSI Group. Improving empiric antibiotic prescribing in pediatric bloodstream infections: a potential application of weighted-incidence syndromic combination antibiograms (WISCA). Expert Rev Anti Infect Ther. 2022;20(3):445–456. doi:10.1080/14787210.2021.1967145.
  • Croft NM, de Ridder L, Griffiths AM, Hyams JS, Ruemmele FM, Turner D, Cheng K, Lutsar I, Greco M, Gołębiewska Z, Laumond F, Cavaller-Bellaubi M, Elgreey A, Altepeter TA, Pallidis C, Norga K, Nelson R, Crandall W, Vassal G. Paediatric Inflammatory Bowel Disease: A Multi-Stakeholder Perspective to Improve Development of Drugs for Children and Adolescents. J Crohns Colitis. 2023 Mar 18;17(2):249-258. doi: 10.1093/ecco-jcc/jjac135.
  • Hill LF, Clements MN, Turner MA, Donà D, Lutsar I, Jacqz-Aigrain E, et al. Optimised versus standard dosing of vancomycin in infants with Gram-positive sepsis (NeoVanc): a multicentre, randomised, open-label, phase 2b, non-inferiority trial. Lancet Child Adolesc Health. 2022;6(1):49–59. doi:10.1016/S2352-4642(21)00305-9.
  • Huik K, Hill S, George J, Pau A, Kuriakose S, Lange CM, et al. High-level dolutegravir resistance can emerge rapidly from few variants and spread by recombination: implications for integrase strand transfer inhibitor salvage therapy. AIDS. 2022;36(13):1835–1840. doi:10.1097/QAD.0000000000003288.
  • Jacobs TG, Schouwenburg S, Penazzato M, Archary M, Ruel TD, van den Anker J, Burger DM, Cressey TR, Abrams EJ, Lyall H, Bekker A, Colbers A; Penta Clinical Pharmacology Working Group; PADO-HIV 5 participants. What babies need: accelerating access to current and novel antiretroviral drugs in neonates through pharmacokinetic studies. Lancet HIV. 2022;9(9):e649–e657. doi:10.1016/S2352-3018(22)00121-7.
  • Kõivumägi K, Geller J, Toompere K, Soeorg H, Kallas E, Jõgeda EL, et al. Norovirus strains among children aged 0–18 years hospitalized with acute gastroenteritis in Estonia 2015–2016. J Med Virol. 2022;94(6):2632–2639. doi:10.1002/jmv.27495.
  • Kopsidas I, De Luca M, Bielicki J, Blázquez-Gamero D, von Both U, Ciliento G, Epalza C, Goycochea Validivia WA, Kolberg L, Lutsar I, Machaira M, Neth O, Oletto A, Tsolia MN, Viltrop AL, Zaoutis T, Spyridis N. Hand hygiene compliance rates in 9 pediatric intensive care units across Europe: results from the Reducing Antimicrobial use and Nosocomial Infections in Kids Network. Pediatr Infect Dis J. 2022;41(10):e434–e437. doi:10.1097/INF.0000000000003658.
  • Lau CY, Adan MA, Earhart J, Seamon C, Nguyen T, Savramis A, Huik K, et al. Imaging and biopsy of HIV-infected individuals undergoing analytic treatment interruption. Front Med. 2022;9:979756. doi:10.3389/fmed.2022.979756.
  • Maasi G, Štšepetova J, Jõesaar M, Olak J, Mändar R. Different patterns of virulence genes in Streptococcus mutans and Streptococcus sobrinus originating from Estonian toddlers—mothers cohort. Microbiol Res. 2022;13(4):928–936. doi:10.3390/microbiolres13040065.
  • Mändar R, Lutsar I, Karki T, Mikelsaar M. Meditsiiniline mikrobioloogia II. Bakterid ja seened. Tartu, Estonia: Tartu Ülikooli Kirjastus; 2022.
  • Naaber P, Lahesaare A, Truu L, Soojärv A, Adamson A, Beljaev K, et al. Rapid screening for variants of concern in routine SARS-CoV-2 PCR diagnostics. J Vaccines Vaccin. 2022;1–2. doi:10.1101/2021.04.01.21254755.
  • Naaber P, Tserel L, Kangro K, Punapart M, Sepp E, Jürjenson V, et al. Protective antibodies and T cell responses to Omicron variant after the booster dose of BNT162b2 vaccine. Cell Rep Med. 2022;3(8):100716. doi:10.1016/j.xcrm.2022.100716.
  • Naaber P, Tserel L, Kangro K, Sepp E, Jürjenson V, Kärner J, et al. Protective antibodies and T cell responses to Omicron variant three months after the booster dose of BNT162b2 vaccine. medRxiv. 2022. doi:10.1101/2022.03.04.22271890.
  • Nguyen ATC, Le Nguyen NT, Hoang TTA, Nguyen TT, Tran TTQ, Tran DNT, Nguyen ATK, Tran LM, Nguyen DHC, Le TM, Ho BD, Rööp T, Kõljalg S, Štšepetova J, Van Le A, Salumets A, Mändar R. Aerobic vaginitis in the third trimester and its impact on pregnancy outcomes. BMC Pregnancy Childbirth. 2022;22(1):432. doi:10.1186/s12884-022-04761-5.
  • COVID-19 Host Genetics Initiative. A first update on mapping the human genetic architecture of COVID-19. Nature. 2022;608(7921):E1–E10. doi:10.1038/s41586-022-04826-7.
  • Sepp E, Smidt I, Rööp T, Štšepetova J, Kõljalg S, Mikelsaar M, et al. Comparative analysis of gut microbiota in centenarians and young people: impact of eating habits and childhood living environment. Front Cell Infect Microbiol. 2022;12:851404. doi:10.3389/fcimb.2022.851404.
  • Soeorg H, Jõgi P, Naaber P, Ottas A, Toompere K, Lutsar I. Seroprevalence and levels of IgG antibodies after COVID-19 infection or vaccination. Infect Dis (Lond). 2022;54(1):63–71. doi:10.1080/23744235.2021.1974540.
  • Soeorg H, Noortoots A, Karu M, Saks K, Lass J, Lutsar I, Kõrgvee LT. Estimation of cefepime, piperacillin, and tazobactam clearance with iohexol-based glomerular filtration rate in paediatric patients. Eur J Clin Pharmacol. 2022;78(6):989–1001. doi:10.1007/s00228-022-03307-0.
  • Soeorg H, Padari H, Kipper K, Ilmoja ML, Lutsar I, Metsvaht T. Pharmacokinetics of gentamicin components C1, C1a, and C2/C2a/C2b and subsequent decline in glomerular filtration rate in neonates. AAPS J. 2022;24(4):77. doi:10.1208/s12248-022-00727-9.
  • Songisepp E, Štšepetova J, Rätsep M, Kuus L, Piir A, Kilk K, Mikelsaar M. Polyfunctional metabolic properties of the human strain Lactiplantibacillus plantarum Inducia (DSM 21379): experimental and clinical approaches. J Funct Foods. 2022;92:105064. doi:10.1016/j.jff.2022.105064.
  • Šebunova N, Štšepetova J, Kullisaar T, Suija K, Rätsep A, Junkin I, et al. Changes in adipokine levels and metabolic profiles following bariatric surgery. BMC Endocr Disord. 2022;22(1):33. doi:10.1186/s12902-022-00942-7.
  • Štšepetova J, Simre K, Tagoma A, Uibo O, Peet A, Siljander H, et al. Maternal breast milk microbiota and immune markers in relation to subsequent development of celiac disease in offspring. Sci Rep. 2022;12(1):6607. doi:10.1038/s41598-022-10679-x.
  • Deferm N, Annink KV, Faelens R, Schroth M, Maiwald CA, Bakkali LE, et al. Glomerular filtration rate in asphyxiated neonates under therapeutic whole-body hypothermia, quantified by mannitol clearance. Clin Pharmacokinet. 2021;60(7):897–906. doi:10.1007/s40262-021-00991-6.
  • Jõgi P, Soeorg H, Ingerainen D, Soots M, Lättekivi F, Naaber P, et al. Prevalence of SARS-CoV-2 IgG antibodies and their association with clinical symptoms of COVID-19 in Estonia (KoroSero-EST-1 study). Vaccine. 2021;39(38):5376–5384. doi:10.1016/j.vaccine.2021.07.093.
  • Jõgi P, Soeorg H, Oona M, Peterson P, Kisand K, Lutsar I. Koroonaviiruse karjaimmuunsus Eestis. KoroSero-EST uuringud. Riigikogu Toimetised. 2021;43:101–108.
  • Kase K, Avi R, Toompere K, Rajasaar H, Pauskar M, Soodla P, et al. Dynamics of hepatitis C epidemic among people living with HIV in Estonia based on Estonian HIV cohort study. BMC Infect Dis. 2021;21(1):792. doi:10.1186/s12879-021-06521-w.
  • Lõivukene K, Kõljalg S, Kermes K, Sepp E, Naaber P. Anaeroobsete bakterite spekter ja antibiootikumitundlikkus 2016. ja 2020. aastal TÜ Kliinikumi ühendlabori kliinilise mikrobioloogia osakonna andmetel. Eesti Arst, 2021,100 (11), 605−614.
  • Kõivumägi K, Soeorg H, Toompere K, Kallas E, Jõgeda EL, Lass E, et al. Rotavirus strain surveillance in Estonia after introduction of rotavirus universal mass vaccination. Pediatr Infect Dis J. 2021;40(5):489–494. doi:10.1097/INF.0000000000003039.
  • Kõljalg S, Vaikjärv R, Smidt I, Rööp T, Chakrabarti A, Kasenõmm P, Mändar R. Effect of erythritol and xylitol on Streptococcus pyogenes causing peritonsillar abscesses. Sci Rep. 2021;11(1):15855. doi:10.1038/s41598-021-95367-y.
  • Lass J, Mitt P, Lutsar I, Telling K, Sepp E, Naaber P. Antimicrobial stewardship in Estonia. Wien Med Wochenschr. 2021;171(Suppl 1):S9–S28. doi:10.1007/s10354-020-00808-4.
  • Lõivukene K, Kermes K, Sepp E, Naaber P, Kõljalg S. Gram-negatiivsete anaeroobsete pulkbakterite diagnostika ja antibiootikumitundlikkuse määramine Tartu Ülikooli Kliinikumi ühendlabori kliinilise mikrobioloogia osakonnas 2016–2020. Eesti Arst. 2021;100(Suppl 1):31.
  • Lõivukene K, Kõljalg S, Kermes K, Sepp E, Naaber P. Anaeroobsete bakterite spekter ja antibiootikumitundlikkus 2016. ja 2020. aastal TÜ Kliinikumi ühendlabori kliinilise mikrobioloogia osakonna andmetel. Eesti Arst. 2021;100(11):605–614.
  • Merits A, Abroi A, Kurg R, Žusinaite E, Truve E, Sarmiento C, Sõmera M, Saar T, Viltrop A, Lutsar I, Avi R, Karki T, Huik K, Kõljalg S, Brilene T, Roots I, Inno H. Üldine ja Meditsiiniline viroloogia. Tartu, Estonia: Tartu Ülikooli Kirjastus; 2021.
  • Mikelsaar M, Mändar R. Commentary: gut microbiome and space travelers' health: state of the art and possible pro/prebiotic strategies for long-term space missions. Front Physiol. 2021;12:651977. doi:10.3389/fphys.2021.651977.
  • Naaber P, Jürjenson V, Adamson A, Sepp E, Tserel L, Kisand K, Peterson P. Antibody response after COVID-19 mRNA vaccination in relation to age, sex, and side effects. Presented at: 37th NSCMID Annual Meeting; 2021; Turku, Finland.
  • Naaber P, Tserel L, Kangro K, Sepp E, Jürjenson V, Adamson A, et al. Dynamics of antibody response to BNT162b2 vaccine after six months: a longitudinal prospective study. Lancet Reg Health Eur. 2021;100208. doi:10.1016/j.lanepe.2021.100208.
  • Naaber P, Tserel L, Kangro K, Sepp E, Jürjenson V, Adamson A, et al. Declined antibody responses to COVID-19 mRNA vaccine within first three months. medRxiv. 2021. doi:10.1101/2021.04.19.21255714.
  • Naaber P, Tserel L, Kangro K, Sepp E, Jürjenson V, Adamson A, Haljasmägi L, Rumm AP, Maruste R, Kärner J, Gerhold JM, Planken A, Ustav M, Kisand K, Peterson P. Dynamics of antibody response to BNT162b2 vaccine after six months: a longitudinal prospective study. Lancet Reg Health Eur. 2021 Sep 6:100208. doi: 10.1016/j.lanepe.2021.100208.
  • Naaber P. SARS-CoV-2 diagnostika algusest ja arengust SYNLABis. Eesti Laborimeditsiin. 2021:31.
  • Padari H, Soeorg H, Tasa T, Metsvaht T, Kipper K, Herodes K, et al. Ampicillin pharmacokinetics during first week of life in preterm and term neonates. Pediatr Infect Dis J. 2021;40(5):464–472. doi:10.1097/INF.0000000000003061.
  • Soeorg H, Jõgi P, Naaber P, Ottas A, Toompere K, Lutsar I. Seroprevalence and levels of IgG antibodies after COVID-19 infection or vaccination. Infect Dis (Lond). 2021. doi:10.1080/23744235.2021.1974540.
  • Soeorg H, Noortoots A, Karu M, Saks K, Lass J, Lutsar I, Kõrgvee LT. Glomerular filtration rate in children and young adults with haemato-oncological disease and infection is best described by three-compartment iohexol model. Pediatr Blood Cancer. 2021;e29305. doi:10.1002/pbc.29305.
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  • Tjagur S, Mändar R, Poolamets O, Pomm K, Punab M. Mycoplasma genitalium provokes seminal inflammation among infertile males. Int J Mol Sci. 2021;22:13467. doi:10.3390/ijms222413467.
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  • Hallik M, Ilmoja ML, Standing JF, Soeorg H, Jalas T, Raidmäe M, Uibo K, Köbas K, Sõnajalg M, Takkis K, Veigure R, Kipper K, Starkopf J, Metsvaht T. Population pharmacokinetics and pharmacodynamics of dobutamine in neonates on the first days of life. Br J Clin Pharmacol. 2020 Feb;86(2):318-328. doi: 10.1111/bcp.14146. Epub 2020 Jan 17. PMID: 31657867; PMCID: PMC7015735.
  • Andersen PI, Ianevski A, Lysvand H, Vitkauskiene A, Oksenych V, Bjørås M, Telling K, Lutsar I, Dumpis U, Irie Y, Tenson T, Kantele A, Kainov DE. Discovery and development of safe-in-man broad-spectrum antiviral agents. Int J Infect Dis. 2020 Apr;93:268-276. doi: 10.1016/j.ijid.2020.02.018. Epub 2020 Feb 17. PMID: 32081774; PMCID: PMC7128205.
  • Hill LF, Turner MA, Lutsar I, Heath PT, Hardy P, Linsell L, Jacqz-Aigrain E, Roilides E, Sharland M; NeoVanc Consortium. An optimised dosing regimen versus a standard dosing regimen of vancomycin for the treatment of late onset sepsis due to Gram-positive microorganisms in neonates and infants aged less than 90 days (NeoVanc): study protocol for a randomised controlled trial. Trials. 2020 Apr 15;21(1):329. doi: 10.1186/s13063-020-4184-8. PMID: 32293527; PMCID: PMC7158076.
  • Jõgi P, Soeorg H, Oona M, Kaart T, Toompere K, Maskina T, Koort I, Rätsep A, Lutsar I; Pertussis study group of Estonia. Dynamics of pertussis toxin IgG after symptomatic pertussis in children and adults. Vaccine. 2020 Apr 3;38(16):3196-3200. doi: 10.1016/j.vaccine.2020.02.080. Epub 2020 Mar 11. PMID:32171577.
  • Kõivumägi K, Toompere K, Soeorg H, Kallas E, Jõgeda EL, Huik K; Rotavirus Study group, Lutsar I. Acute gastroenteritis hospitalizations after implementation of universal mass vaccination against rotavirus. Vaccine. 2020 Mar 17;38(13):2879-2886. doi: 10.1016/j.vaccine.2020.01.098. Epub 2020 Feb 14. PMID: 32067818.
  • Kõljalg S, Smidt I, Chakrabarti A, Bosscher D, Mändar R. Exploration of singular and synergistic effect of xylitol and erythritol on causative agents of dental caries. Sci Rep. 2020 Apr 14;10(1):6297. doi: 10.1038/s41598-020-63153-x. PMID: 32286378; PMCID: PMC7156733.
  • Lutsar I, Chazallon C, Trafojer U, de Cabre VM, Auriti C, Bertaina C, Calo Carducci FI, Canpolat FE, Esposito S, Fournier I, Hallik M, Heath PT, Ilmoja ML, Iosifidis E, Kuznetsova J, Meyer L, Metsvaht T, Mitsiakos G, Pana ZD, Mosca F, Pugni L, Roilides E, Rossi P, Sarafidis K, Sanchez L, Sharland M, Usonis V, Warris A, Aboulker JP, Giaquinto C; NeoMero Consortium. Meropenem vs standard of care for treatment of neonatal late onset sepsis (NeoMero1): A randomized controlled trial. PLoS One. 2020 Mar 4;15(3):e0229380. doi: 10.1371/journal.pone.0229380. PMID: 32130261; PMCID: PMC7055900.
  • Naaber P, Hunt K, Pesukova J, Haljasmägi L, Rumm P, Peterson P, Hololejenko J, Eero I, Jõgi P, Toompere K, Sepp E. Evaluation of SARS-CoV-2 IgG antibody response in PCR positive patients: Comparison of nine tests in relation to clinical data. PLoS One. 2020 Oct 27;15(10):e0237548. doi: 10.1371/journal.pone.0237548. PMID: 33108380; PMCID: PMC7591045.
  • Telling K, Brauer A, Laht M, Kalmus P, Toompere K, Kisand V, Maimets M, Remm M, Tenson T, Lutsar I. Characteristics of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae and Contact to Animals in Estonia. Microorganisms. 2020 Jul 27;8(8):1130. doi: 10.3390/microorganisms8081130. PMID: 32727011; PMCID: PMC7465280.
  • Tjagur S, Mändar R, Punab M. Profile of sexually transmitted infections causing urethritis and a related inflammatory reaction in urine among heterosexual males: A flow-cytometry study. PLoS One. 2020 Dec 2;15(12):e0242227. doi: 10.1371/journal.pone.0242227. PMID: 33264307; PMCID: PMC7710099.
  • Veerus P, Salumets A, Naaber P, Krjutškov K, Tilk K, Laanpere M, Uusküla A. Seroprevalence of SARS-CoV-2 antibodies among pregnant women in Estonia: A call for epidemiological studies. Acta Obstet Gynecol Scand. 2020 Dec;99(12):1736-1737. doi: 10.1111/aogs.13995. Epub 2020 Oct 8. PMID: 32970836; PMCID: PMC7537018.
  • Bilozor A, Balode A, Chakhunashvili G, Chumachenko T, Egorova S, Ivanova M, Kaftyreva L, Kõljalg S, Kõressaar T, Lysenko O, Miciuleviciene J, Mändar R, Lis DO, Wesolowska MP, Ratnik K, Remm M, Rudzko J, Rööp T, Saule M, Sepp E, Shyshporonok J, Titov L, Tsereteli D, Naaber P. Application of Molecular Methods for Carbapenemase Detection. Front Microbiol. 2019 Aug 2;10:1755.
  • Esposito S, Stefanelli P, Fry NK, Fedele G, He Q, Paterson P, Tan T, Knuf M, Rodrigo C, Weil Olivier C, Flanagan KL, Hung I, Lutsar I, Edwards K, O'Ryan M, Principi N; World Association of Infectious Diseases and Immunological Disorders (WAidid) and the Vaccine Study Group of the European Society of Clinical Microbiology and Infectious Diseases (EVASG). Pertussis Prevention: Reasons for Resurgence, and Differences in the Current Acellular Pertussis Vaccines. Front Immunol. 2019 Jul 3;10:1344.
  • Hallik M, Ilmoja ML, Tasa T, Standing JF, Takkis K, Veigure R, Kipper K, Jalas T, Raidmäe M, Uibo K, Starkopf J, Metsvaht T. Population Pharmacokinetics and Dosing of Milrinone After Patent Ductus Arteriosus Ligation in Preterm Infants. Pediatr Crit Care Med. 2019 Jul;20(7):621-629.
  • Huik K, Soodla P, Pauskar M, Owen SM, Luo W, Murphy G, Jõgeda EL, Kallas E, Rajasaar H, Avi R, Masciotra S, Lutsar I; CASCADE Collaboration in the EuroCoord. The concordance of the limiting antigen and the Bio-Rad avidity assays in persons from Estonia infected mainly with HIV-1 CRF06_cpx. PLoS One. 2019 May 24;14(5):e0217048.
  • Ianevski A, Zusinaite E, Shtaida N, Kallio-Kokko H, Valkonen M, Kantele A, Telling K, Lutsar I, Letjuka P, Metelitsa N, Oksenych V, Dumpis U, Vitkauskiene A, Stašaitis K, Öhrmalm C, Bondeson K, Bergqvist A, Cox RJ, Tenson T, Merits A, Kainov DE. Low Temperature and Low UV Indexes Correlated with Peaks of Influenza Virus Activity in Northern Europe during 2010⁻2018. Viruses. 2019 Mar 1;11(3). pii: E207.
  • Jacqz-Aigrain E, Leroux S, Thomson AH, Allegaert K, Capparelli EV, Biran V, Simon N, Meibohm B, Lo YL, Marques R, Peris JE, Lutsar I, Saito J, Nakamura H, van den Anker JN, Sharland M, Zhao W. Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young infants. J Antimicrob Chemother. 2019 Aug 1;74(8):2128-2138.
  • Mikelsaar M, Lõivukene K, Naaber P, Mändar R. Helicobacter pylori infektsioonide teaduspõhine diagnostika ja mikroobidevastane ravi. Eesti Arst 2019; 98(7):381-384.
  • Mändar R, Türk S, Korrovits P, Ausmees K, Punab M. Impact of sexual debut on culturable human seminal microbiota. Andrology. 2018 May;6(3):510-512.
  • Mändar R, Korrovits P, Rahu K, Rahu M, Sibul EL, Mehik A, Punab M. Dramatically deteriorated quality of life in men with prostatitis-like symptoms. Andrology. 2019 May 15. doi: 10.1111/andr.12647. [Epub ahead of print]
  • Minh Tam Le, Thi Le Na Nguyen, Duong Dinh Le, Tram Viet Quynh Ngo, Anh Thi Chau Nguyen, Bach Hoang Nguyen, Huy Vu Quoc Nguyen, Thanh Ngoc Cao, Salumets A, Mändar R. (2019). Does genital tract infection relate to tubal diseases in Vietnamese infertile women? Journal of Infection in Developing Countries, x [ilmumas].
  • Rostok M, Hütt P, Rööp T, Smidt I, Štšepetova J, Salumets A, Mändar R. Potential vaginal probiotics: safety, tolerability and preliminary effectiveness. Benef Microbes. 2019 Apr 19;10(4):385-393.
  • Soeorg H, Metsvaht HK, Keränen EE, Eelmäe I, Merila M, Ilmoja ML, Metsvaht T, Lutsar I. Genetic Relatedness of Staphylococcus haemolyticus in Gut and Skin of Preterm Neonates and Breast Milk of Their Mothers. Pediatr Infect Dis J. 2019 Mar;38(3):308-313.
  • Soodla P, Huik K, Pauskar M, Cuypers L, Van Laethem K, Rajasaar H, Kallas E, Lepa H, Velts-Lindh A, Jõgeda EL, Lutsar I, Avi R. Stable level of HIV transmitted drug resistance in Estonia despite significant scale-up of antiretroviral therapy. Infect Genet Evol. 2019 May 28:103901. doi: 10.1016/j.meegid.2019.05.019. [Epub ahead of print].
  • Štšepetova J, Truu J, Runnel R, Nõmmela R, Saag M, Olak J, Nõlvak H, Preem JK, Oopkaup K, Krjutškov K, Honkala E, Honkala S, Mäkinen K, Mäkinen PL, Vahlberg T, Vermeiren J, Bosscher D, de Cock P, Mändar R. Impact of polyols on Oral microbiome of Estonian schoolchildren. BMC Oral Health. 2019 Apr 18;19(1):60.
  • Šebunova N, Štšepetova J, Sillakivi T, Mändar R. The Prevalence of Helicobacter pylori in Estonian Bariatric Surgery Patients. Int J Mol Sci. 2018 Jan 24;19(2). pii: E338.
  • Vaikjärv R, Mändar R, Kasenõmm P. Peritonsillar abscess is frequently accompanied by sepsis symptoms. Eur Arch Otorhinolaryngol. 2019 Jun;276(6):1721-1725.
  • Bichele R, Kärner J, Truusalu K, Smidt I, Mändar R, Conti HR, Gaffen SL, Peterson P, Laan M, Kisand K. IL-22 neutralizing autoantibodies impair fungal clearance in murine oropharyngeal candidiasis model. Eur J Immunol. 2018 Mar;48(3):464-470.
  • Dyar OJ, Nathwani D, Monnet DL, Gyssens IC, Stålsby Lundborg C, Pulcini C; ESGAP Student-PREPARE Working Group. Do medical students feel prepared to prescribe antibiotics responsibly? Results from a cross-sectional survey in 29 European countries. J Antimicrob Chemother. 2018 Aug 1;73(8):2236-2242.
  • Germovsek E, Lutsar I, Kipper K, Karlsson MO, Planche T, Chazallon C, Meyer L, Trafojer UMT, Metsvaht T, Fournier I, Sharland M, Heath P, Standing JF; NeoMero Consortium. Plasma and CSF pharmacokinetics of meropenem in neonates and young infants: results from the NeoMero studies. J Antimicrob Chemother. 2018 Jul 1;73(7):1908-1916.
  • Ianevski A, Zusinaite E, Shtaida N, Kallio-Kokko H, Valkonen M, Kantele A, Telling K, Lutsar I, Letjuka P, Metelitsa N, Oksenych V, Dumpis U, Vitkauskiene A, Stašaitis K, Öhrmalm C, Bondeson K, Bergqvist A, Cox RJ, Tenson T, Merits A, Kainov DE. Low Temperature and Low UV Indexes Correlated with Peaks of Influenza Virus Activity in Northern Europe during 2010⁻2018. Viruses. 2019 Mar 1;11(3).
  • Ianevski A, Zusinaite E, Kuivanen S, Strand M, Lysvand H, Teppor M, Kakkola L, Paavilainen H, Laajala M, Kallio-Kokko H, Valkonen M, Kantele A, Telling K, Lutsar I, Letjuka P, Metelitsa N, Oksenych V, Bjørås M, Nordbø SA, Dumpis U, Vitkauskiene A, Öhrmalm C, Bondeson K, Bergqvist A, Aittokallio T, Cox RJ, Evander M, Hukkanen V, Marjomaki V, Julkunen I, Vapalahti O, Tenson T, Merits A, Kainov D. Novel activities of safe-in-human broad-spectrum antiviral agents. Antiviral Res. 2018 Jun;154:174-182.
  • Jõgeda EL, Avi R, Pauskar M, Kallas E, Karki T, Des Jarlais D, Uusküla A, Toompere K, Lutsar I, Huik K. Association of IFNλ4 rs12979860 polymorphism with the acquisition of HCV and HIV infections among people who inject drugs. J Med Virol. 2018 Nov;90(11):1779-1783.
  • Jõgi P, Oona M, Kaart T, Toompere K, Maskina T, Koort I, Rätsep A, Lutsar I. Pertussis and parapertussis in children and adults with a persistent cough: an observational study. Infection. 2018 Feb;46(1):83-91.
  • Kogermann K, Lass J, Nellis G, Metsvaht T, Lutsar I. Age-appropriate formulations including pharmaceutical excipients in neonatal medicines. Current Pharmaceutical Design, 2018, 23, 5779−5789.
  • Lemsalu L, Rice B, Uusküla A, Raag M, Lutsar I, Rüütel K. How to ascertain an accurate number of people living with diagnosed HIV and fill data gaps from the past - lessons learned from a high prevalence setting in Europe. 22nd International AIDS Conference, Amsterdam, the Netherlands, 23-27 July 2018. International AIDS Society,.
  • Mändar R, Türk S, Korrovits P, Ausmees K, Punab M. Impact of sexual debut on culturable human seminal microbiota. Andrology. 2018 May;6(3):510-512.
  • Padari H, Metsvaht T, Germovsek E, Barker CI, Kipper K, Herodes K, Standing JF, Oselin K, Tasa T, Soeorg H, Lutsar I. Pharmacokinetics of Penicillin G in Preterm and Term Neonates. Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e02238-17.
  • Pansa P, Hsia Y, Bielicki J, Lutsar I, Walker AS, Sharland M, Folgori L. Evaluating Safety Reporting in Paediatric Antibiotic Trials, 2000-2016: A Systematic Review and Meta-Analysis. Drugs. 2018 Feb;78(2):231-244.
  • Parm Ü, Štšepetova J, Eelmäe I, Merila M, Ilmoja ML, Metsvaht T, Lutsar I, Soeorg H. Genetic relatedness of Gram-negative bacteria colonizing gut and skin of neonates and mother's own milk. J Perinatol. 2018 Nov;38(11):1503-1511.
  • Šebunova N, Štšepetova J, Sillakivi T, Mändar R. The Prevalence of Helicobacter pylori in Estonian Bariatric Surgery Patients. Int J Mol Sci. 2018 Jan 24;19(2). pii: E338.
  • Sepp E, Smidt I, Stsepetova J, Roop T, Hutt P, Ratsep M, Mikelsaar M. The effect of Lactobacillus fermentum ME-3 on the intestinal microbiota and urine polyamines content: A double-blind placebo-controlled pilot trial. Journal of Functional Foods, 2018, 48, 430−438.
  • Soeorg H, Treumuth S, Metsvaht HK, Eelmäe I, Merila M, Ilmoja ML, Lutsar I, Metsvaht T. Higher intake of coagulase-negative staphylococci from maternal milk promotes gut colonization with mecA-negative Staphylococcus epidermidis in preterm neonates. J Perinatol. 2018 Oct;38(10):1344-1352.
  • Soodla P, Simmons R, Huik K, Pauskar M, Jõgeda EL, Rajasaar H, Kallaste E, Maimets M, Avi R, Murphy G, Porter K, Lutsar I; Concerted Action on SeroConversion to AIDS and Death in Europe (CASCADE) Collaboration in EuroCoord. HIV incidence in the Estonian population in 2013 determined using the HIV-1 limiting antigen avidity assay. HIV Med. 2018 Jan;19(1):33-41.
  • Stirrup OT, Copas AJ, Phillips AN, Gill MJ, Geskus RB, Touloumi G, Young J, Bucher HC, Babiker AG; CASCADE Collaboration in EuroCoord. Predictors of CD4 cell recovery following initiation of antiretroviral therapy among HIV-1 positive patients with well-estimated dates of seroconversion. HIV Med. 2018 Mar;19(3):184-194.
  • Telling K, Laht M, Brauer A, Remm M, Kisand V, Maimets M, Tenson T, Lutsar I. Multidrug resistant Pseudomonas aeruginosa in Estonian hospitals. BMC Infect Dis. 2018 Oct 11;18(1):513.
  • Tjagur S, Mändar R, Punab M. Prevalence of Mycoplasma genitalium and other sexually transmitted infections causing urethritis among high-risk heterosexual male patients in Estonia. Infect Dis (Lond). 2018 Feb;50(2):133-139.
  • Ahonen M, Kahru A, Ivask A, Kasemets K, Kõljalg S, Mantecca P, Vinković Vrček I, Keinänen-Toivola MM, Crijns F. Proactive Approach for Safe Use of Antimicrobial Coatings in Healthcare Settings: Opinion of the COST Action Network AMiCI. Int J Environ Res Public Health. 2017 Mar 31;14(4). pii: E366.
  • Drell T, Štšepetova J, Simm J, Rull K, Aleksejeva A, Antson A, Tillmann V, Metsis M, Sepp E, Salumets A, Mändar R. The Influence of Different Maternal Microbial Communities on the Development of Infant Gut and Oral Microbiota. Sci Rep. 2017 Aug 30;7(1):9940.
  • Fearnhill E, Gourlay A, Malyuta R, Simmons R, Ferns RB, Grant P, Nastouli E, Karnets I, Murphy G, Medoeva A, Kruglov Y, Yurchenko A, Porter K; Concerted Action on SeroConversion to AIDS and Death in Europe (CASCADE) Collaboration in EuroCoord. A Phylogenetic Analysis of Human Immunodeficiency Virus Type 1 Sequences in Kiev: Findings Among Key Populations. Clin Infect Dis. 2017 Oct 1;65(7):1127-1135.
  • Ghosn J, Bayan T, Meixenberger K, Tran L, Frange P, d'Arminio Monforte A, Zangerle R, de Mendoza C, Krastinova E, Porter K, Meyer L, Chaix ML; CASCADE Collaboration in EuroCoord. CD4 T cell decline following HIV seroconversion in individuals with and without CXCR4-tropic virus. J Antimicrob Chemother. 2017 Oct 1;72(10):2862-2868.
  • Hallik M, Tasa T, Starkopf J, Metsvaht T. Dosing of Milrinone in Preterm Neonates to Prevent Postligation Cardiac Syndrome: Simulation Study Suggests Need for Bolus Infusion. Neonatology. 2017;111(1):8-11.
  • Jõgeda EL, Huik K, Pauskar M, Kallas E, Karki T, Des Jarlais D, Uusküla A, Lutsar I, Avi R. Prevalence and genotypes of GBV-C and its associations with HIV infection among persons who inject drugs in Eastern Europe. J Med Virol. 2017 Apr;89(4):632-638.
  • Kogermann K, Lass J, Nellis G, Metsvaht T, Lutsar I. Age-Appropriate Formulations Including Pharmaceutical Excipients in Neonatal Medicines. Curr Pharm Des. 2017;23(38):5779-5789.
  • Korrovits P, Poolamets O, Mändar R, Punab M. Inflammatory reaction found in prostate-specific material - method standardization and proposed optimal cut-off points. Andrology. 2017 Sep;5(5):958-963.
  • Kõljalg S, Mändar R, Sõber T, Rööp T, Mändar R. High level bacterial contamination of secondary school students' mobile phones. Germs. 2017 Jun 1;7(2):73-77.
  • Laisaar KT, Raag M, Lutsar I, Uusküla A. People living with HIV in Estonia: engagement in HIV care in 2013. Euro Surveill. 2016 Oct 27;21(43).
  • Maaroos, H.-I., Mikelsaar, M., Vorobjova, T. Helicobacter pylori avastamise lugu: kliinilised, immunoloogilised ja mikrobioloogilised aspektid. Eesti uurijate panus Nobeli auhinnaga pärjatud uuringutesse. Tartu Ülikooli ajaloo küsimusi XLV. Muutuste sajand Eesti meditsiinis. Tartu Ülikooli Muuseum, 2017, 76-101.
  • Mikelsaar, M. Teadmiste spiraal. Sajand inimese mikroobiökoloogiat Tartu Ülikoolis. Tartu Ülikooli ajaloo küsimusi XLV. Muutuste sajand Eesti meditsiinis. Tartu Ülikooli Muuseum, 2017, 102-117.
  • Mändar R, Punab M, Korrovits P, Türk S, Ausmees K, Lapp E, Preem JK, Oopkaup K, Salumets A, Truu J. Seminal microbiome in men with and without prostatitis. Int J Urol. 2017 Mar;24(3):211-216.
  • Neubert A, Baarslag MA, Dijk MV, Rosmalen JV, Standing JF, Sheng Y, Rascher W, Roberts D, Winslade J, Rawcliffe L, Hanning SM, Metsvaht T, Giannuzzi V, Larsson P, Pokorná P, Simonetti A, Tibboel D; CLOSED Consortium. The CLOSED trial; CLOnidine compared with midazolam for SEDation of paediatric patients in the intensive care unit: study protocol for a multicentre randomised controlled trial. BMJ Open. 2017 Jun 21;7(6):e016031.
  • Padari H, Oselin K, Tasa T, Metsvaht T, Lõivukene K, Lutsar I. Coagulase negative staphylococcal sepsis in neonates: do we need to adapt vancomycin dose or target? BMC Pediatr. 2016 Dec 8;16(1):206.
  • Rätsep M, Kõljalg S, Sepp E, Smidt I, Truusalu K, Songisepp E, Stsepetova J, Naaber P, Mikelsaar R-H, Mikelsaar M. A combination of the probiotic and prebiotic product can prevent the germination of Clostridium difficile spores and infection. Anaerobe, 2017, 47, 94−103.
  • Roosaare M, Vaher M, Kaplinski L, Möls M, Andreson R, Lepamets M, Kõressaar T, Naaber P, Kõljalg S, Remm M. StrainSeeker: fast identification of bacterial strains from raw sequencing reads using user-provided guide trees. PeerJ. 2017 May 18;5:e3353.
  • Soeorg H, Huik K, Parm Ü, Ilmoja ML, Metsvaht T, Lutsar I. Molecular epidemiology of Staphylococcus epidermidis in neonatal intensive care units. APMIS. 2017 Jan;125(1):63-73.
  • Soeorg H, Metsvaht T, Eelmäe I, Merila M, Treumuth S, Huik K, Jürna-Ellam M, Ilmoja ML, Lutsar I. The role of breast milk in the colonization of neonatal gut and skin with coagulase-negative staphylococci. Pediatr Res. 2017 Nov;82(5):759-767.
  • Soeorg H, Metsvaht T, Eelmäe I, Metsvaht HK, Treumuth S, Merila M, Ilmoja ML, Lutsar I. Coagulase-Negative Staphylococci in Human Milk From Mothers of Preterm Compared With Term Neonates. J Hum Lact. 2017 May;33(2):329-340.
  • Štšepetova J, Taelma H, Smidt I, Hütt P, Lapp E, Aotäht E, Mändar R. Assessment of phenotypic and genotypic antibiotic susceptibility of vaginal Lactobacillus sp. J Appl Microbiol. 2017 Aug;123(2):524-534
  • Taba P, Schmutzhard E, Forsberg P, Lutsar I, Ljøstad U, Mygland Å, Levchenko I, Strle F, Steiner I. EAN consensus review on prevention, diagnosis and management of tick-borne encephalitis. Eur J Neurol. 2017 Oct;24(10):1214-e61.
  • Tasa T, Metsvaht T, Kalamees R, Vilo J, Lutsar I. DosOpt: A Tool for Personalized Bayesian Dose Adjustment of Vancomycin in Neonates. Ther Drug Monit. 2017 Dec;39(6):604-613.
  • Thompson G, Barker CI, Folgori L, Bielicki JA, Bradley JS, Lutsar I, Sharland M. Global shortage of neonatal and paediatric antibiotic trials: rapid review. BMJ Open. 2017 Oct 13;7(10):e016293.
  • Veigure R, Aro R, Metsvaht T, Standing JF, Lutsar I, Herodes K, Kipper K; CloSed Consortium. A highly sensitive method for the simultaneous UHPLC-MS/MS analysis of clonidine, morphine, midazolam and their metabolites in blood plasma using HFIP as the eluent additive. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 May 1;1052:150-157.
  • Vengerfeldt V, Mändar R, Nguyen MS, Saukas S, Saag M. Apical periodontitis in southern Estonian population: prevalence and associations with quality of root canal fillings and coronal restorations. BMC Oral Health. 2017 Dec 12;17(1):147.
  • Vengerfeldt V, Mändar R, Saag M, Piir A, Kullisaar T. Oxidative stress in patients with endodontic pathologies. J Pain Res. 2017 Aug 24;10:2031-2040.
  • Avi R, Pauskar M, Karki T, Kallas E, Jõgeda E-L, Margus T, Huik K, Lutsar I. Prevalence of drug resistAnce mutations in HAART patients infected with HIV-1 CRF06_cpx in Estonia. Journal of Medical Virology, 2016, 88 (3), 448−454.
  • Bielicki JA, Sharland M, Johnson AP, Henderson KL, Cromwell DA; Antibiotic Resistance and Prescribing in European Children project. Selecting appropriate empirical antibiotic regimens for paediatric bloodstream infections: application of a Bayesian decision model to local and pooled antimicrobial resistance surveillance data. J Antimicrob Chemother. 2016 Mar;71(3):794-802.
  • Brauer A, Telling K, Laht M, Kalmus P, Lutsar I, Remm M, Kisand V, Tenson T. Plasmid with Colistin Resistance Gene mcr-1 in Extended-Spectrum-β-Lactamase-Producing Escherichia coli Strains Isolated from Pig Slurry in Estonia. Antimicrob Agents Chemother. 2016 Oct 21;60(11):6933-6936.
  • Folgori L, Bielicki J, Ruiz B, Turner MA, Bradley JS, Benjamin DK Jr, Zaoutis TE, Lutsar I, Giaquinto C, Rossi P, Sharland M. Harmonisation in study design and outcomes in paediatric antibiotic clinical trials: a systematic review. Lancet Infect Dis. 2016 Sep;16(9):e178-e189.
  • Germovsek E, Kent A, Metsvaht T, Lutsar I, Klein N, Turner MA, Sharland M, Nielsen EI, Heath PT, Standing JF. Development and Evaluation of a Gentamicin Pharmacokinetic Model That Facilitates Opportunistic Gentamicin Therapeutic Drug Monitoring in Neonates and Infants. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4869-77.
  • Huik K, Avi R, Pauskar M, Kallas E, Jõgeda EL, Karki T, Rüütel K, Talu A, Abel-Ollo K, Uusküla A, Carrillo A, Ahuja SK, He W, Lutsar I. A CCL5 Haplotype Is Associated with Low Seropositivity Rate of HCV Infection in People Who Inject Drugs. PLoS One. 2016 Jun 15;11(6):e0156850.
  • Hütt P, Lapp E, Štšepetova J, Smidt I, Taelma H, Borovkova N, Oopkaup H, Ahelik A, Rööp T, Hoidmets D, Samuel K, Salumets A, Mändar R. Characterisation of probiotic properties in human vaginal lactobacilli strains. Microb Ecol Health Dis. 2016 Aug 12;27:30484.
  • Jõgeda EL, Avi R, Pauskar M, Kallas E, Karki T, Des Jarlais D, Uusküla A, Lutsar I, Huik K. Human T-lymphotropic virus types 1 and 2 are rare among intravenous drug users in Eastern Europe. Infect Genet Evol. 2016 Sep;43:83-5.
  • Kallas E, Huik K, Türk S, Pauskar M, Jõgeda EL, Šunina M, Karki T, Des Jarlais D, Uusküla A, Avi R, Lutsar I. T Cell Distribution in Relation to HIV/HBV/HCV Coinfections and Intravenous Drug Use. Viral Immunol. 2016 Oct;29(8):464-470.
  • Kallas E, Huik K, Türk S, Pauskar M, Jõgeda EL, Šunina M, Karki T, Des Jarlais D, Uusküla A, Avi R, Lutsar I. Differences in T cell distribution and CCR5 expression in HIV-positive and HIV-exposed seronegative persons who inject drugs. Med Microbiol Immunol. 2016 Jun;205(3):231-9
  • Korrovits P, Lapp E, Mandar R. Couple-related factors of ART outcome. Clin Exp Obstet Gynecol. 2016;43(5):747-750.
  • Laisaar KT, Raag M, Lutsar I, Uusküla A. People living with HIV in Estonia: engagement in HIV care in 2013. Euro Surveill. 2016 Oct 27;21(43).
  • Mändar K, Sõber T, Kõljalg S, Rööp,T, Mändar R, Sepp E. Microbiological contamination of the euro currency in Estonia. Infectious Diseases, 2016, 48 (10), 772−774.
  • Mikelsaar M, Sepp E, Štšepetova J, Songisepp E, Mändar R. Biodiversity of Intestinal Lactic Acid Bacteria in the Healthy Population. Adv Exp Med Biol. 2016;932:1-64.
  • Nellis G, Metsvaht T, Varendi H, Lass J, Duncan J, Nunn AJ, Turner MA, Lutsar I. Product Substitution as a Way Forward in Avoiding Potentially Harmful Excipients in Neonates. Paediatr Drugs. 2016 Jun;18(3):221-30.
  • Padari H, Oselin K, Tasa T, Metsvaht T, Lõivukene K, Lutsar I. Coagulase negative staphylococcal sepsis in neonates: do we need to adapt vancomycin dose or target? BMC Pediatrics, 2016, 16 (1), 206−206.
  • Pantazis N, Touloumi G, Meyer L, Olson A, Costagliola D, Kelleher AD, Lutsar I, Chaix ML, Fisher M, Moreno S, Porter K; CASCADE Collaboration in EuroCoord. The impact of transient combination antiretroviral treatment in early HIV infection on viral suppression and immunologic response in later treatment. AIDS. 2016 Mar 27;30(6):879-88.
  • Spyridis N, Syridou G, Goossens H, Versporten A, Kopsidas J, Kourlaba G, Bielicki J, Drapier N, Zaoutis T, Tsolia M, Sharland M; ARPEC Project Group Members. Variation in paediatric hospital antibiotic guidelines in Europe. Arch Dis Child. 2016 Jan;101(1):72-6.
  • Tamme K, Oselin K, Kipper K, Tasa T, Metsvaht T, Karjagin J, Herodes K, Kern H, Starkopf J. Pharmacokinetics and pharmacodynamics of piperacillin/tazobactam during high volume haemodiafiltration in patients with septic shock. Acta Anaesthesiol Scand. 2016 Feb;60(2):230-40.
  • Vaikjärv R, Kasenõmm P, Jaanimäe L, Kivisild A, Rööp T, Sepp E, Mändar R. Microbiology of peritonsillar abscess in the South Estonian population. Microb Ecol Health Dis. 2016 Apr 22;27:27787.
  • Patentne leiutis: Vaginaalsed Lactobacillus crispatus probiootilised tüved urogenitaaltrakti tervise heaks.; Omanikud: Tervisetehnoloogiate Arenduskeskus AS (endine Reproduktiivmeditsiini TAK AS); Autorid: Reet Mändar, Pirje Hütt, Imbi Smidt, Jelena Štšepetova, Eleri Lapp, Mariheleen Rostok, Gertu Sõerunurk, Tiiu Rööp, Dagmar Hoidmets, Hardi Tamm, Marit Kolk, Sander Piiskop, Triin Palmiste, Kairi Koort, Andres Salumets; Prioriteedi number: 1816425.1; Prioriteedi kuupäev: 9.10.2018.
  • Patentne leiutis: Lactobacillus fermentum ME-3 for use in trating metabolic syndrome related diseases; Omanikud: Tartu Ülikool, meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut; Autorid: Tiiu Kullisaar, Mihkel Zilmer, Imbi Smidt, Kersti Zilmer, Marika Mikelsaar, Pirje Hütt; Prioriteedi number: EP2943210B1; Prioriteedi kuupäev: 10.01.2018.
  • Patentne leiutis: Method of treatment using Lactobacillus fermentum ME-3; Omanikud: Tartu Ülikool, meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut; Autorid: Tiiu Kullisaar, Mihkel Zilmer, Imbi Smidt, Kersti Zilmer, Marika Mikelsaar, Pirje Hütt; Prioriteedi number: WO2013IB61216 20131220; GB20120023370 20121224; Prioriteedi kuupäev: 14.09.2015.
  • Patentne leiutis: Mikroorganismi tüvi lactobacillus fermentum ME-3 kui antimikroobne ja antioksüdantne probiootikum; Omanikud: Tartu Ülikool, meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut; Autorid: Marika Mikelsaar, Mihkel Zilmer, Epp Songisepp, Tiiu Kullisaar, Heidi Annuk; Prioriteedi number: P200100356; Prioriteedi kuupäev: 29.06.2001.
  • Patentne leiutis: Isoleeritud mikroorganismide tüved Lactobacillus plantarum MCC1 DSM 23881 ja Lactobacillus gasseri MCC2 DSM 23882 ning nende kasutamine; Omanikud: Tervisliku Piima Biotehnoloogiate Arenduskeskus OÜ; Autorid: Epp Songisepp, Lauri Bobrovski, Kersti Ehrlich, Marika Mikelsaar, Tiiu Kullisaar, Mihkel Zilmer, Ene Tammsaar, Andre Veskioja, Kersti Zilmer, Merle Rätsep, Margus Punab, Maire Vasar; Prioriteedi number: EE201100012; Prioriteedi kuupäev: 25.02.2011.
  • Patentne leiutis: Isoleeritud mikroorganismi tüvi Lactobacillus plantarum Inducia DSM 21379 kui organismi loomulikku kaitsevõimet tõstev probiootik, seda sisaldav toiduaine ja kompositsioon ning mikroorganismi kasutamine rakulist immuunsust tõstva ravimi valmistamiseks; Omanikud: BioCC OÜ; Autorid: Epp Songisepp, Jelena Stsepetova, Kalle Kilk, Marika Mikelsaar, Imbi Smidt, Pirje Hütt, Mihkel Zilmer, Kai Truusalu; Prioriteedi number: EE05341; Prioriteedi kuupäev: 13.05.2008.
  • Patentne leiutis: Isolated Lactobacillus plantarum strain Inducia DSM 21379 as probiotic that enhances natural immunity and food products and medicinal preparations comprising it; Omanikud: Tervisliku Piima Biotehnoloogiate Arenduskeskus OÜ; Autorid: Marika Mikelsaar, Imbi Smidt, Jelena Stsepetova, Mihkel Zilmer, Pirje Hütt, Kai Truusalu, Kalle Kilk; Prioriteedi number: P200800027; Prioriteedi kuupäev: 13.05.2008.
  • Patentne leiutis: Isolated microorganism strain Lactobacillus plantarum Tensia DSM 21380 as antimicrobial and antihypertensive probiotic, food product and composition comprising said microorganism and use of said microorganism for preparation of antihypertensive medicine and method for suppressing pathogens and non-starter lactobacilli in food product; Omanikud: Tervisliku Piima Biotehnoloogiate Arenduskeskus OÜ; Autorid: Marika Mikelsaar, Merle Rätsep, Mihkel Zilmer, Pirje Hütt, Kersti Zilmer, Janne Üksti, Siiri Kõljalg; Prioriteedi number: P200800026; Prioriteedi kuupäev: 13.05.2008.
  • Patentne leiutis: Isoleeritud mikroorganismi tüvi Lactobacillus plantarum Inducia DSM 21379 kui organismi loomulikku kaitsevõimet tõstev probiootik, seda sisaldav toiduaine ja kompositsioon ning mikroorganismi kasutamine rakulist immuunsust tõstva ravimi valmistamiseks; Omanikud: Tervisliku Piima Biotehnoloogiate Arenduskeskus OÜ; Autorid: Marika Mikelsaar, Epp Songisepp, Imbi Smidt, Jelena Stsepetova, Pirje Hütt, Mihkel Zilmer, Kai Truusalu, Kalle Kilk; Prioriteedi number: PCT/EE2009/000006; Prioriteedi kuupäev: 13.05.2008.
  • Patentne leiutis: Composition comprising a probiotic microorganism strain Lactobacillus plantarum Inducia DSM 21379 as hypocholesterolemic and antimicrobial agent for use in preventing cardiovascular disorders Clostridium difficile associated diarrhoea; Omanikud: BioCC OÜ ; Autorid: Marika Mikelsaar, Epp Songisepp, Merle Rätsep, Pirje Hütt, Imbi Smidt, Kai Truusalu, Epp Sepp, Raik-Hiio Mikelsaar, Kalle Kilk, Jelena Štšepetova, Siiri Kõljalg, Mirjam Vallas; Prioriteedi number: US201414244284 20140403; Prioriteedi kuupäev: 16.11.2015.
  • Patentne leiutis: Hüpokolestereemiline ja clostridium difficile suhtes antimikrobiaalne agent Lactobacillus plantarum INDUCIA tüvi DSM 21379; Omanikud: Tervisliku Piima Biotehnoloogiate Arenduskeskus OÜ; Autorid: Epp Songisepp, Jelena Stsepetova, Siiri Kõljalg, Marika Mikelsaar, Merle Rätsep, Mirjam Vallas, Pirje Hütt, Imbi Smidt, Kai Truusalu, Epp Sepp, Raik-Hiio Mikelsaar, Kalle Kilk; Prioriteedi number: P201400038; Prioriteedi kuupäev: 30.07.2014.