Publications and patents of the Department of Microbiology

24.11.2021
#research

 

2021

  • Jõgi P, Soeorg H, Ingerainen D, Soots M, Lättekivi F, Naaber P, Toompere K, Peterson P, Haljasmägi L, Žusinaite E, Vaas H, Pauskar M, Shablinskaja A, Kaarna K, Paluste H, Kisand K, Oona M, Janno R, Lutsar I. Prevalence of SARS-CoV-2 IgG antibodies and their association with clinical symptoms of COVID-19 in Estonia (KoroSero-EST-1 study). Vaccine. 2021 Sep 7;39(38):5376-5384. doi: 10.1016/j.vaccine.2021.07.093. Epub 2021 Aug 5. PMID: 34393019; PMCID: PMC8339569.
  • Kase K, Avi R, Toompere K, Rajasaar H, Pauskar M, Soodla P, Jõgeda EL, Zilmer K, Lutsar I, Huik K. Dynamics of hepatitis C epidemic among people living with HIV in Estonia based on Estonian HIV cohort study. BMC Infect Dis. 2021 Aug 10;21(1):792. doi: 10.1186/s12879-021-06521-w. PMID: 34376170; PMCID: PMC8353725.
  • Kõivumägi K, Soeorg H, Toompere K, Kallas E, Jõegeda EL, Lass E, Huik K, Lutsar I; RV Study group. Rotavirus Strain Surveillance in Estonia After Introduction of Rotavirus Universal Mass Vaccination. Pediatr Infect Dis J. 2021 May 1;40(5):489-494. doi: 10.1097/INF.0000000000003039. PMID: 33847298.
  • Kõljalg S, Vaikjärv R, Smidt I, Rööp T, Chakrabarti A, Kasenõmm P, Mändar R. Effect of erythritol and xylitol on Streptococcus pyogenes causing peritonsillar abscesses. Sci Rep. 2021 Aug 4;11(1):15855. doi: 10.1038/s41598-021-95367-y. PMID: 34349211; PMCID: PMC8339055.
  • Mikelsaar M, Mändar R. Commentary: Gut Microbiome and Space Travelers' Health: State of the Art and Possible Pro/Prebiotic Strategies for Long-Term Space Missions. Front Physiol. 2021 Mar 23;12:651977. doi: 10.3389/fphys.2021.651977. PMID: 33833693; PMCID: PMC8021706.
  • Naaber P, Tserel L, Kangro K, Sepp E, Jürjenson V, Adamson A, Haljasmägi L, Rumm AP, Maruste R, Kärner J, Gerhold JM, Planken A, Ustav M, Kisand K, Peterson P. Dynamics of antibody response to BNT162b2 vaccine after six months: a longitudinal prospective study. Lancet Reg Health Eur. 2021 Sep 6:100208. doi: 10.1016/j.lanepe.2021.100208. Epub ahead of print. PMID: 34514454; PMCID: PMC8418937.
  • Padari H, Soeorg H, Tasa T, Metsvaht T, Kipper K, Herodes K, Oselin K, Hallik M, Ilmoja ML, Lutsar I. Ampicillin Pharmacokinetics During First Week of Life in Preterm and Term Neonates. Pediatr Infect Dis J. 2021 May 1;40(5):464-472. doi: 10.1097/INF.0000000000003061. PMID: 33591074.
  • Soeorg H, Jõgi P, Naaber P, Ottas A, Toompere K, Lutsar I. Seroprevalence and levels of IgG antibodies after COVID-19 infection or vaccination. Infect Dis (Lond). 2021 Sep 14:1-9. doi: 10.1080/23744235.2021.1974540. Epub ahead of print. PMID: 34520315; PMCID: PMC8442755.
  • Soeorg H, Noortoots A, Karu M, Saks K, Lass J, Lutsar I, Kõrgvee LT. Glomerular filtration rate in children and young adults with haemato-oncological disease and infection is best described by three-compartment iohexol model. Pediatr Blood Cancer. 2021 Sep 2:e29305. doi: 10.1002/pbc.29305. Epub ahead of print. PMID: 34472203.
  • Tang BH, Guan Z, Allegaert K, Wu YE, Manolis E, Leroux S, Yao BF, Shi HY, Li X, Huang X, Wang WQ, Shen AD, Wang XL, Wang TY, Kou C, Xu HY, Zhou Y, Zheng Y, Hao GX, Xu BP, Thomson AH, Capparelli EV, Biran V, Simon N, Meibohm B, Lo YL, Marques R, Peris JE, Lutsar I, Saito J, Burggraaf J, Jacqz-Aigrain E, van den Anker J, Zhao W. Drug Clearance in Neonates: A Combination of Population Pharmacokinetic Modelling and Machine Learning Approaches to Improve Individual Prediction. Clin Pharmacokinet. 2021 May 27. doi: 10.1007/s40262-021-01033-x. Epub ahead of print. PMID: 34041714.
  • Tserel L, Jõgi P, Naaber P, Maslovskaja J, Häling A, Salumets A, Zusinaite E, Soeorg H, Lättekivi F, Ingerainen D, Soots M, Toompere K, Kaarna K, Kisand K, Lutsar I, Peterson P. Long-Term Elevated Inflammatory Protein Levels in Asymptomatic SARS-CoV-2 Infected Individuals. Front Immunol. 2021 Sep 17;12:709759. doi: 10.3389/fimmu.2021.709759. PMID: 34603283; PMCID: PMC8484961.
  • Williams PCM, Bradley J, Roilides E, Olson L, Kaplan S, Lutsar I, Giaquinto C, Benjamin DK, Sharland M. Harmonising regulatory approval for antibiotics in children. Lancet Child Adolesc Health. 2021 Feb;5(2):96-98. doi: 10.1016/S2352-4642(20)30365-5. PMID: 33484666.
  • Deferm N, Annink KV, Faelens R, Schroth M, Maiwald CA, Bakkali LE, van Bel F, Benders MJNL, van Weissenbruch MM, Hagen A, Smits A, Annaert P, Franz AR, Allegaert K; ALBINO Study Group. Glomerular Filtration Rate in Asphyxiated Neonates Under Therapeutic Whole-Body Hypothermia, Quantified by Mannitol Clearance. Clin Pharmacokinet. 2021 Jul;60(7):897-906. doi: 10.1007/s40262-021-00991-6. Epub 2021 Feb 21. PMID: 33611729; PMCID: PMC8249265.
  • Hallik M, Ilmoja ML, Standing JF, Soeorg H, Jalas T, Raidmäe M, Uibo K, Köbas K, Sõnajalg M, Takkis K, Veigure R, Kipper K, Starkopf J, Metsvaht T. Population pharmacokinetics and pharmacodynamics of dobutamine in neonates on the first days of life. Br J Clin Pharmacol. 2020 Feb;86(2):318-328. doi: 10.1111/bcp.14146. Epub 2020 Jan 17. PMID: 31657867; PMCID: PMC7015735.
  • Andersen PI, Ianevski A, Lysvand H, Vitkauskiene A, Oksenych V, Bjørås M, Telling K, Lutsar I, Dumpis U, Irie Y, Tenson T, Kantele A, Kainov DE. Discovery and development of safe-in-man broad-spectrum antiviral agents. Int J Infect Dis. 2020 Apr;93:268-276. doi: 10.1016/j.ijid.2020.02.018. Epub 2020 Feb 17. PMID: 32081774; PMCID: PMC7128205.
  • Hill LF, Turner MA, Lutsar I, Heath PT, Hardy P, Linsell L, Jacqz-Aigrain E, Roilides E, Sharland M; NeoVanc Consortium. An optimised dosing regimen versus a standard dosing regimen of vancomycin for the treatment of late onset sepsis due to Gram-positive microorganisms in neonates and infants aged less than 90 days (NeoVanc): study protocol for a randomised controlled trial. Trials. 2020 Apr 15;21(1):329. doi: 10.1186/s13063-020-4184-8. PMID: 32293527; PMCID: PMC7158076.
  • Jõgi P, Soeorg H, Oona M, Kaart T, Toompere K, Maskina T, Koort I, Rätsep A, Lutsar I; Pertussis study group of Estonia. Dynamics of pertussis toxin IgG after symptomatic pertussis in children and adults. Vaccine. 2020 Apr 3;38(16):3196-3200. doi: 10.1016/j.vaccine.2020.02.080. Epub 2020 Mar 11. PMID:32171577.
  • Kõivumägi K, Toompere K, Soeorg H, Kallas E, Jõgeda EL, Huik K; Rotavirus Study group, Lutsar I. Acute gastroenteritis hospitalizations after implementation of universal mass vaccination against rotavirus. Vaccine. 2020 Mar 17;38(13):2879-2886. doi: 10.1016/j.vaccine.2020.01.098. Epub 2020 Feb 14. PMID: 32067818.
  • Kõljalg S, Smidt I, Chakrabarti A, Bosscher D, Mändar R. Exploration of singular and synergistic effect of xylitol and erythritol on causative agents of dental caries. Sci Rep. 2020 Apr 14;10(1):6297. doi: 10.1038/s41598-020-63153-x. PMID: 32286378; PMCID: PMC7156733.
  • Lutsar I, Chazallon C, Trafojer U, de Cabre VM, Auriti C, Bertaina C, Calo Carducci FI, Canpolat FE, Esposito S, Fournier I, Hallik M, Heath PT, Ilmoja ML, Iosifidis E, Kuznetsova J, Meyer L, Metsvaht T, Mitsiakos G, Pana ZD, Mosca F, Pugni L, Roilides E, Rossi P, Sarafidis K, Sanchez L, Sharland M, Usonis V, Warris A, Aboulker JP, Giaquinto C; NeoMero Consortium. Meropenem vs standard of care for treatment of neonatal late onset sepsis (NeoMero1): A randomized controlled trial. PLoS One. 2020 Mar 4;15(3):e0229380. doi: 10.1371/journal.pone.0229380. PMID: 32130261; PMCID: PMC7055900.
  • Naaber P, Hunt K, Pesukova J, Haljasmägi L, Rumm P, Peterson P, Hololejenko J, Eero I, Jõgi P, Toompere K, Sepp E. Evaluation of SARS-CoV-2 IgG antibody response in PCR positive patients: Comparison of nine tests in relation to clinical data. PLoS One. 2020 Oct 27;15(10):e0237548. doi: 10.1371/journal.pone.0237548. PMID: 33108380; PMCID: PMC7591045.
  • Telling K, Brauer A, Laht M, Kalmus P, Toompere K, Kisand V, Maimets M, Remm M, Tenson T, Lutsar I. Characteristics of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae and Contact to Animals in Estonia. Microorganisms. 2020 Jul 27;8(8):1130. doi: 10.3390/microorganisms8081130. PMID: 32727011; PMCID: PMC7465280.
  • Tjagur S, Mändar R, Punab M. Profile of sexually transmitted infections causing urethritis and a related inflammatory reaction in urine among heterosexual males: A flow-cytometry study. PLoS One. 2020 Dec 2;15(12):e0242227. doi: 10.1371/journal.pone.0242227. PMID: 33264307; PMCID: PMC7710099.
  • Veerus P, Salumets A, Naaber P, Krjutškov K, Tilk K, Laanpere M, Uusküla A. Seroprevalence of SARS-CoV-2 antibodies among pregnant women in Estonia: A call for epidemiological studies. Acta Obstet Gynecol Scand. 2020 Dec;99(12):1736-1737. doi: 10.1111/aogs.13995. Epub 2020 Oct 8. PMID: 32970836; PMCID: PMC7537018.
  • Bilozor A, Balode A, Chakhunashvili G, Chumachenko T, Egorova S, Ivanova M, Kaftyreva L, Kõljalg S, Kõressaar T, Lysenko O, Miciuleviciene J, Mändar R, Lis DO, Wesolowska MP, Ratnik K, Remm M, Rudzko J, Rööp T, Saule M, Sepp E, Shyshporonok J, Titov L, Tsereteli D, Naaber P. Application of Molecular Methods for Carbapenemase Detection. Front Microbiol. 2019 Aug 2;10:1755.
  • Esposito S, Stefanelli P, Fry NK, Fedele G, He Q, Paterson P, Tan T, Knuf M, Rodrigo C, Weil Olivier C, Flanagan KL, Hung I, Lutsar I, Edwards K, O'Ryan M, Principi N; World Association of Infectious Diseases and Immunological Disorders (WAidid) and the Vaccine Study Group of the European Society of Clinical Microbiology and Infectious Diseases (EVASG). Pertussis Prevention: Reasons for Resurgence, and Differences in the Current Acellular Pertussis Vaccines. Front Immunol. 2019 Jul 3;10:1344.
  • Hallik M, Ilmoja ML, Tasa T, Standing JF, Takkis K, Veigure R, Kipper K, Jalas T, Raidmäe M, Uibo K, Starkopf J, Metsvaht T. Population Pharmacokinetics and Dosing of Milrinone After Patent Ductus Arteriosus Ligation in Preterm Infants. Pediatr Crit Care Med. 2019 Jul;20(7):621-629.
  • Huik K, Soodla P, Pauskar M, Owen SM, Luo W, Murphy G, Jõgeda EL, Kallas E, Rajasaar H, Avi R, Masciotra S, Lutsar I; CASCADE Collaboration in the EuroCoord. The concordance of the limiting antigen and the Bio-Rad avidity assays in persons from Estonia infected mainly with HIV-1 CRF06_cpx. PLoS One. 2019 May 24;14(5):e0217048.
  • Ianevski A, Zusinaite E, Shtaida N, Kallio-Kokko H, Valkonen M, Kantele A, Telling K, Lutsar I, Letjuka P, Metelitsa N, Oksenych V, Dumpis U, Vitkauskiene A, Stašaitis K, Öhrmalm C, Bondeson K, Bergqvist A, Cox RJ, Tenson T, Merits A, Kainov DE. Low Temperature and Low UV Indexes Correlated with Peaks of Influenza Virus Activity in Northern Europe during 2010⁻2018. Viruses. 2019 Mar 1;11(3). pii: E207.
  • Jacqz-Aigrain E, Leroux S, Thomson AH, Allegaert K, Capparelli EV, Biran V, Simon N, Meibohm B, Lo YL, Marques R, Peris JE, Lutsar I, Saito J, Nakamura H, van den Anker JN, Sharland M, Zhao W. Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young infants. J Antimicrob Chemother. 2019 Aug 1;74(8):2128-2138.
  • Mikelsaar M, Lõivukene K, Naaber P, Mändar R. Helicobacter pylori infektsioonide teaduspõhine diagnostika ja mikroobidevastane ravi. Eesti Arst 2019; 98(7):381-384. 
  • Mändar R, Türk S, Korrovits P, Ausmees K, Punab M. Impact of sexual debut on culturable human seminal microbiota. Andrology. 2018 May;6(3):510-512.
  • Mändar R, Korrovits P, Rahu K, Rahu M, Sibul EL, Mehik A, Punab M. Dramatically deteriorated quality of life in men with prostatitis-like symptoms. Andrology. 2019 May 15. doi: 10.1111/andr.12647. [Epub ahead of print]
  • Minh Tam Le, Thi Le Na Nguyen, Duong Dinh Le, Tram Viet Quynh Ngo, Anh Thi Chau Nguyen, Bach Hoang Nguyen, Huy Vu Quoc Nguyen, Thanh Ngoc Cao, Salumets A, Mändar R. (2019). Does genital tract infection relate to tubal diseases in Vietnamese infertile women? Journal of Infection in Developing Countries, x [ilmumas].
  • Rostok M, Hütt P, Rööp T, Smidt I, Štšepetova J, Salumets A, Mändar R. Potential vaginal probiotics: safety, tolerability and preliminary effectiveness. Benef Microbes. 2019 Apr 19;10(4):385-393.
  • Soeorg H, Metsvaht HK, Keränen EE, Eelmäe I, Merila M, Ilmoja ML, Metsvaht T, Lutsar I. Genetic Relatedness of Staphylococcus haemolyticus in Gut and Skin of Preterm Neonates and Breast Milk of Their Mothers. Pediatr Infect Dis J. 2019 Mar;38(3):308-313.
  • Soodla P, Huik K, Pauskar M, Cuypers L, Van Laethem K, Rajasaar H, Kallas E, Lepa H, Velts-Lindh A, Jõgeda EL, Lutsar I, Avi R. Stable level of HIV transmitted drug resistance in Estonia despite significant scale-up of antiretroviral therapy. Infect Genet Evol. 2019 May 28:103901. doi: 10.1016/j.meegid.2019.05.019. [Epub ahead of print].
  • Štšepetova J, Truu J, Runnel R, Nõmmela R, Saag M, Olak J, Nõlvak H, Preem JK, Oopkaup K, Krjutškov K, Honkala E, Honkala S, Mäkinen K, Mäkinen PL, Vahlberg T, Vermeiren J, Bosscher D, de Cock P, Mändar R. Impact of polyols on Oral microbiome of Estonian schoolchildren. BMC Oral Health. 2019 Apr 18;19(1):60.
  • Šebunova N, Štšepetova J, Sillakivi T, Mändar R. The Prevalence of Helicobacter pylori in Estonian Bariatric Surgery Patients. Int J Mol Sci. 2018 Jan 24;19(2). pii: E338.
  • Vaikjärv R, Mändar R, Kasenõmm P. Peritonsillar abscess is frequently accompanied by sepsis symptoms. Eur Arch Otorhinolaryngol. 2019 Jun;276(6):1721-1725.
  • Bichele R, Kärner J, Truusalu K, Smidt I, Mändar R, Conti HR, Gaffen SL, Peterson P, Laan M, Kisand K. IL-22 neutralizing autoantibodies impair fungal clearance in murine oropharyngeal candidiasis model. Eur J Immunol. 2018 Mar;48(3):464-470.
  • Dyar OJ, Nathwani D, Monnet DL, Gyssens IC, Stålsby Lundborg C, Pulcini C; ESGAP Student-PREPARE Working Group. Do medical students feel prepared to prescribe antibiotics responsibly? Results from a cross-sectional survey in 29 European countries. J Antimicrob Chemother. 2018 Aug 1;73(8):2236-2242.
  • Germovsek E, Lutsar I, Kipper K, Karlsson MO, Planche T, Chazallon C, Meyer L, Trafojer UMT, Metsvaht T, Fournier I, Sharland M, Heath P, Standing JF; NeoMero Consortium. Plasma and CSF pharmacokinetics of meropenem in neonates and young infants: results from the NeoMero studies. J Antimicrob Chemother. 2018 Jul 1;73(7):1908-1916.
  • Ianevski A, Zusinaite E, Shtaida N, Kallio-Kokko H, Valkonen M, Kantele A, Telling K, Lutsar I, Letjuka P, Metelitsa N, Oksenych V, Dumpis U, Vitkauskiene A, Stašaitis K, Öhrmalm C, Bondeson K, Bergqvist A, Cox RJ, Tenson T, Merits A, Kainov DE. Low Temperature and Low UV Indexes Correlated with Peaks of Influenza Virus Activity in Northern Europe during 2010⁻2018. Viruses. 2019 Mar 1;11(3).
  • Ianevski A, Zusinaite E, Kuivanen S, Strand M, Lysvand H, Teppor M, Kakkola L, Paavilainen H, Laajala M, Kallio-Kokko H, Valkonen M, Kantele A, Telling K, Lutsar I, Letjuka P, Metelitsa N, Oksenych V, Bjørås M, Nordbø SA, Dumpis U, Vitkauskiene A, Öhrmalm C, Bondeson K, Bergqvist A, Aittokallio T, Cox RJ, Evander M, Hukkanen V, Marjomaki V, Julkunen I, Vapalahti O, Tenson T, Merits A, Kainov D. Novel activities of safe-in-human broad-spectrum antiviral agents. Antiviral Res. 2018 Jun;154:174-182.
  • Jõgeda EL, Avi R, Pauskar M, Kallas E, Karki T, Des Jarlais D, Uusküla A, Toompere K, Lutsar I, Huik K. Association of IFNλ4 rs12979860 polymorphism with the acquisition of HCV and HIV infections among people who inject drugs. J Med Virol. 2018 Nov;90(11):1779-1783.
  • Jõgi P, Oona M, Kaart T, Toompere K, Maskina T, Koort I, Rätsep A, Lutsar I. Pertussis and parapertussis in children and adults with a persistent cough: an observational study. Infection. 2018 Feb;46(1):83-91.
  • Kogermann K, Lass J, Nellis G, Metsvaht T, Lutsar I. Age-appropriate formulations including pharmaceutical excipients in neonatal medicines. Current Pharmaceutical Design, 2018, 23, 5779−5789.
  • Lemsalu L, Rice B, Uusküla A, Raag M, Lutsar I, Rüütel K. How to ascertain an accurate number of people living with diagnosed HIV and fill data gaps from the past - lessons learned from a high prevalence setting in Europe. 22nd International AIDS Conference, Amsterdam, the Netherlands, 23-27 July 2018. International AIDS Society,.
  • Mändar R, Türk S, Korrovits P, Ausmees K, Punab M. Impact of sexual debut on culturable human seminal microbiota. Andrology. 2018 May;6(3):510-512.
  • Padari H, Metsvaht T, Germovsek E, Barker CI, Kipper K, Herodes K, Standing JF, Oselin K, Tasa T, Soeorg H, Lutsar I. Pharmacokinetics of Penicillin G in Preterm and Term Neonates. Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e02238-17.
  • Pansa P, Hsia Y, Bielicki J, Lutsar I, Walker AS, Sharland M, Folgori L. Evaluating Safety Reporting in Paediatric Antibiotic Trials, 2000-2016: A Systematic Review and Meta-Analysis. Drugs. 2018 Feb;78(2):231-244.
  • Parm Ü, Štšepetova J, Eelmäe I, Merila M, Ilmoja ML, Metsvaht T, Lutsar I, Soeorg H. Genetic relatedness of Gram-negative bacteria colonizing gut and skin of neonates and mother's own milk. J Perinatol. 2018 Nov;38(11):1503-1511.
  • Šebunova N, Štšepetova J, Sillakivi T, Mändar R. The Prevalence of Helicobacter pylori in Estonian Bariatric Surgery Patients. Int J Mol Sci. 2018 Jan 24;19(2). pii: E338.
  • Sepp E, Smidt I, Stsepetova J, Roop T, Hutt P, Ratsep M, Mikelsaar M. The effect of Lactobacillus fermentum ME-3 on the intestinal microbiota and urine polyamines content: A double-blind placebo-controlled pilot trial. Journal of Functional Foods, 2018, 48, 430−438.
  • Soeorg H, Treumuth S, Metsvaht HK, Eelmäe I, Merila M, Ilmoja ML, Lutsar I, Metsvaht T. Higher intake of coagulase-negative staphylococci from maternal milk promotes gut colonization with mecA-negative Staphylococcus epidermidis in preterm neonates. J Perinatol. 2018 Oct;38(10):1344-1352.
  • Soodla P, Simmons R, Huik K, Pauskar M, Jõgeda EL, Rajasaar H, Kallaste E, Maimets M, Avi R, Murphy G, Porter K, Lutsar I; Concerted Action on SeroConversion to AIDS and Death in Europe (CASCADE) Collaboration in EuroCoord. HIV incidence in the Estonian population in 2013 determined using the HIV-1 limiting antigen avidity assay. HIV Med. 2018 Jan;19(1):33-41.
  • Stirrup OT, Copas AJ, Phillips AN, Gill MJ, Geskus RB, Touloumi G, Young J, Bucher HC, Babiker AG; CASCADE Collaboration in EuroCoord. Predictors of CD4 cell recovery following initiation of antiretroviral therapy among HIV-1 positive patients with well-estimated dates of seroconversion. HIV Med. 2018 Mar;19(3):184-194.
  • Telling K, Laht M, Brauer A, Remm M, Kisand V, Maimets M, Tenson T, Lutsar I. Multidrug resistant Pseudomonas aeruginosa in Estonian hospitals. BMC Infect Dis. 2018 Oct 11;18(1):513.
  • Tjagur S, Mändar R, Punab M. Prevalence of Mycoplasma genitalium and other sexually transmitted infections causing urethritis among high-risk heterosexual male patients in Estonia. Infect Dis (Lond). 2018 Feb;50(2):133-139.
  • Ahonen M, Kahru A, Ivask A, Kasemets K, Kõljalg S, Mantecca P, Vinković Vrček I, Keinänen-Toivola MM, Crijns F. Proactive Approach for Safe Use of Antimicrobial Coatings in Healthcare Settings: Opinion of the COST Action Network AMiCI. Int J Environ Res Public Health. 2017 Mar 31;14(4). pii: E366.
  • Drell T, Štšepetova J, Simm J, Rull K, Aleksejeva A, Antson A, Tillmann V, Metsis M, Sepp E, Salumets A, Mändar R. The Influence of Different Maternal Microbial Communities on the Development of Infant Gut and Oral Microbiota. Sci Rep. 2017 Aug 30;7(1):9940.
  • Fearnhill E, Gourlay A, Malyuta R, Simmons R, Ferns RB, Grant P, Nastouli E, Karnets I, Murphy G, Medoeva A, Kruglov Y, Yurchenko A, Porter K; Concerted Action on SeroConversion to AIDS and Death in Europe (CASCADE) Collaboration in EuroCoord. A Phylogenetic Analysis of Human Immunodeficiency Virus Type 1 Sequences in Kiev: Findings Among Key Populations. Clin Infect Dis. 2017 Oct 1;65(7):1127-1135.
  • Ghosn J, Bayan T, Meixenberger K, Tran L, Frange P, d'Arminio Monforte A, Zangerle R, de Mendoza C, Krastinova E, Porter K, Meyer L, Chaix ML; CASCADE Collaboration in EuroCoord. CD4 T cell decline following HIV seroconversion in individuals with and without CXCR4-tropic virus. J Antimicrob Chemother. 2017 Oct 1;72(10):2862-2868.
  • Hallik M, Tasa T, Starkopf J, Metsvaht T. Dosing of Milrinone in Preterm Neonates to Prevent Postligation Cardiac Syndrome: Simulation Study Suggests Need for Bolus Infusion. Neonatology. 2017;111(1):8-11.
  • Jõgeda EL, Huik K, Pauskar M, Kallas E, Karki T, Des Jarlais D, Uusküla A, Lutsar I, Avi R. Prevalence and genotypes of GBV-C and its associations with HIV infection among persons who inject drugs in Eastern Europe. J Med Virol. 2017 Apr;89(4):632-638.
  • Kogermann K, Lass J, Nellis G, Metsvaht T, Lutsar I. Age-Appropriate Formulations Including Pharmaceutical Excipients in Neonatal Medicines. Curr Pharm Des. 2017;23(38):5779-5789.
  • Korrovits P, Poolamets O, Mändar R, Punab M. Inflammatory reaction found in prostate-specific material - method standardization and proposed optimal cut-off points. Andrology. 2017 Sep;5(5):958-963.
  • Kõljalg S, Mändar R, Sõber T, Rööp T, Mändar R. High level bacterial contamination of secondary school students' mobile phones. Germs. 2017 Jun 1;7(2):73-77.
  • Laisaar KT, Raag M, Lutsar I, Uusküla A. People living with HIV in Estonia: engagement in HIV care in 2013. Euro Surveill. 2016 Oct 27;21(43).
  • Maaroos, H.-I., Mikelsaar, M., Vorobjova, T. Helicobacter pylori avastamise lugu: kliinilised, immunoloogilised ja mikrobioloogilised aspektid. Eesti uurijate panus Nobeli auhinnaga pärjatud uuringutesse. Tartu Ülikooli ajaloo küsimusi XLV. Muutuste sajand Eesti meditsiinis. Tartu Ülikooli Muuseum, 2017, 76-101.
  • Mikelsaar, M. Teadmiste spiraal. Sajand inimese mikroobiökoloogiat Tartu Ülikoolis. Tartu Ülikooli ajaloo küsimusi XLV. Muutuste sajand Eesti meditsiinis. Tartu Ülikooli Muuseum, 2017, 102-117.
  • Mändar R, Punab M, Korrovits P, Türk S, Ausmees K, Lapp E, Preem JK, Oopkaup K, Salumets A, Truu J. Seminal microbiome in men with and without prostatitis. Int J Urol. 2017 Mar;24(3):211-216.
  • Neubert A, Baarslag MA, Dijk MV, Rosmalen JV, Standing JF, Sheng Y, Rascher W, Roberts D, Winslade J, Rawcliffe L, Hanning SM, Metsvaht T, Giannuzzi V, Larsson  P, Pokorná P, Simonetti A, Tibboel D; CLOSED Consortium. The CLOSED trial; CLOnidine compared with midazolam for SEDation of paediatric patients in the intensive care unit: study protocol for a multicentre randomised controlled trial. BMJ Open. 2017 Jun 21;7(6):e016031.
  • Padari H, Oselin K, Tasa T, Metsvaht T, Lõivukene K, Lutsar I. Coagulase negative staphylococcal sepsis in neonates: do we need to adapt vancomycin dose or target? BMC Pediatr. 2016 Dec 8;16(1):206.
  • Rätsep M, Kõljalg S, Sepp E, Smidt I, Truusalu K, Songisepp E, Stsepetova J, Naaber P, Mikelsaar R-H, Mikelsaar M. A combination of the probiotic and prebiotic product can prevent the germination of Clostridium difficile spores and infection. Anaerobe, 2017, 47, 94−103.
  • Roosaare M, Vaher M, Kaplinski L, Möls M, Andreson R, Lepamets M, Kõressaar T, Naaber P, Kõljalg S, Remm M. StrainSeeker: fast identification of bacterial strains from raw sequencing reads using user-provided guide trees. PeerJ. 2017 May 18;5:e3353.
  • Soeorg H, Huik K, Parm Ü, Ilmoja ML, Metsvaht T, Lutsar I. Molecular epidemiology of Staphylococcus epidermidis in neonatal intensive care units. APMIS. 2017 Jan;125(1):63-73.
  • Soeorg H, Metsvaht T, Eelmäe I, Merila M, Treumuth S, Huik K, Jürna-Ellam M, Ilmoja ML, Lutsar I. The role of breast milk in the colonization of neonatal gut and skin with coagulase-negative staphylococci. Pediatr Res. 2017 Nov;82(5):759-767.
  • Soeorg H, Metsvaht T, Eelmäe I, Metsvaht HK, Treumuth S, Merila M, Ilmoja ML, Lutsar I. Coagulase-Negative Staphylococci in Human Milk From Mothers of Preterm Compared With Term Neonates. J Hum Lact. 2017 May;33(2):329-340.
  • Štšepetova J, Taelma H, Smidt I, Hütt P, Lapp E, Aotäht E, Mändar R. Assessment of phenotypic and genotypic antibiotic susceptibility of vaginal Lactobacillus sp. J Appl Microbiol. 2017 Aug;123(2):524-534
  • Taba P, Schmutzhard E, Forsberg P, Lutsar I, Ljøstad U, Mygland Å, Levchenko I, Strle F, Steiner I. EAN consensus review on prevention, diagnosis and management of tick-borne encephalitis. Eur J Neurol. 2017 Oct;24(10):1214-e61.
  • Tasa T, Metsvaht T, Kalamees R, Vilo J, Lutsar I. DosOpt: A Tool for Personalized Bayesian Dose Adjustment of Vancomycin in Neonates. Ther Drug Monit. 2017 Dec;39(6):604-613.
  • Thompson G, Barker CI, Folgori L, Bielicki JA, Bradley JS, Lutsar I, Sharland M. Global shortage of neonatal and paediatric antibiotic trials: rapid review. BMJ Open. 2017 Oct 13;7(10):e016293.
  • Veigure R, Aro R, Metsvaht T, Standing JF, Lutsar I, Herodes K, Kipper K; CloSed Consortium. A highly sensitive method for the simultaneous UHPLC-MS/MS analysis of clonidine, morphine, midazolam and their metabolites in blood plasma using HFIP as the eluent additive. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 May 1;1052:150-157.
  • Vengerfeldt V, Mändar R, Nguyen MS, Saukas S, Saag M. Apical periodontitis in southern Estonian population: prevalence and associations with quality of root canal fillings and coronal restorations. BMC Oral Health. 2017 Dec 12;17(1):147.
  • Vengerfeldt V, Mändar R, Saag M, Piir A, Kullisaar T. Oxidative stress in patients with endodontic pathologies. J Pain Res. 2017 Aug 24;10:2031-2040.
  • Avi R, Pauskar M, Karki T, Kallas E, Jõgeda E-L, Margus T, Huik K, Lutsar I. Prevalence of drug resistAnce mutations in HAART patients infected with HIV-1 CRF06_cpx in Estonia. Journal of Medical Virology, 2016, 88 (3), 448−454.
  • Bielicki JA, Sharland M, Johnson AP, Henderson KL, Cromwell DA; Antibiotic Resistance and Prescribing in European Children project. Selecting appropriate empirical antibiotic regimens for paediatric bloodstream infections: application of a Bayesian decision model to local and pooled antimicrobial resistance surveillance data. J Antimicrob Chemother. 2016 Mar;71(3):794-802.
  • Brauer A, Telling K, Laht M, Kalmus P, Lutsar I, Remm M, Kisand V, Tenson T. Plasmid with Colistin Resistance Gene mcr-1 in Extended-Spectrum-β-Lactamase-Producing Escherichia coli Strains Isolated from Pig Slurry in Estonia. Antimicrob Agents Chemother. 2016 Oct 21;60(11):6933-6936.
  • Folgori L, Bielicki J, Ruiz B, Turner MA, Bradley JS, Benjamin DK Jr, Zaoutis TE, Lutsar I, Giaquinto C, Rossi P, Sharland M. Harmonisation in study design and outcomes in paediatric antibiotic clinical trials: a systematic review. Lancet Infect Dis. 2016 Sep;16(9):e178-e189.
  • Germovsek E, Kent A, Metsvaht T, Lutsar I, Klein N, Turner MA, Sharland M, Nielsen EI, Heath PT, Standing JF. Development and Evaluation of a Gentamicin Pharmacokinetic Model That Facilitates Opportunistic Gentamicin Therapeutic Drug Monitoring in Neonates and Infants. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4869-77.
  • Huik K, Avi R, Pauskar M, Kallas E, Jõgeda EL, Karki T, Rüütel K, Talu A, Abel-Ollo K, Uusküla A, Carrillo A, Ahuja SK, He W, Lutsar I. A CCL5 Haplotype Is Associated with Low Seropositivity Rate of HCV Infection in People Who Inject Drugs. PLoS One. 2016 Jun 15;11(6):e0156850.
  • Hütt P, Lapp E, Štšepetova J, Smidt I, Taelma H, Borovkova N, Oopkaup H, Ahelik A, Rööp T, Hoidmets D, Samuel K, Salumets A, Mändar R. Characterisation of probiotic properties in human vaginal lactobacilli strains. Microb Ecol Health Dis. 2016 Aug 12;27:30484.
  • Jõgeda EL, Avi R, Pauskar M, Kallas E, Karki T, Des Jarlais D, Uusküla A, Lutsar I, Huik K. Human T-lymphotropic virus types 1 and 2 are rare among intravenous drug users in Eastern Europe. Infect Genet Evol. 2016 Sep;43:83-5.
  • Kallas E, Huik K, Türk S, Pauskar M, Jõgeda EL, Šunina M, Karki T, Des Jarlais D, Uusküla A, Avi R, Lutsar I. T Cell Distribution in Relation to HIV/HBV/HCV Coinfections and Intravenous Drug Use. Viral Immunol. 2016 Oct;29(8):464-470.
  • Kallas E, Huik K, Türk S, Pauskar M, Jõgeda EL, Šunina M, Karki T, Des Jarlais D, Uusküla A, Avi R, Lutsar I. Differences in T cell distribution and CCR5 expression in HIV-positive and HIV-exposed seronegative persons who inject drugs. Med Microbiol Immunol. 2016 Jun;205(3):231-9
  • Korrovits P, Lapp E, Mandar R. Couple-related factors of ART outcome. Clin Exp Obstet Gynecol. 2016;43(5):747-750.
  • Laisaar KT, Raag M, Lutsar I, Uusküla A. People living with HIV in Estonia: engagement in HIV care in 2013. Euro Surveill. 2016 Oct 27;21(43).
  • Mändar K, Sõber T, Kõljalg S, Rööp,T, Mändar R, Sepp E. Microbiological contamination of the euro currency in Estonia. Infectious Diseases, 2016, 48 (10), 772−774.
  • Mikelsaar M, Sepp E, Štšepetova J, Songisepp E, Mändar R. Biodiversity of Intestinal Lactic Acid Bacteria in the Healthy Population. Adv Exp Med Biol. 2016;932:1-64.
  • Nellis G, Metsvaht T, Varendi H, Lass J, Duncan J, Nunn AJ, Turner MA, Lutsar I. Product Substitution as a Way Forward in Avoiding Potentially Harmful Excipients in Neonates. Paediatr Drugs. 2016 Jun;18(3):221-30.
  • Padari H, Oselin K, Tasa T, Metsvaht T, Lõivukene K, Lutsar I. Coagulase negative staphylococcal sepsis in neonates: do we need to adapt vancomycin dose or target? BMC Pediatrics, 2016, 16 (1), 206−206.
  • Pantazis N, Touloumi G, Meyer L, Olson A, Costagliola D, Kelleher AD, Lutsar I, Chaix ML, Fisher M, Moreno S, Porter K; CASCADE Collaboration in EuroCoord. The impact of transient combination antiretroviral treatment in early HIV infection on viral suppression and immunologic response in later treatment. AIDS. 2016 Mar 27;30(6):879-88.
  • Spyridis N, Syridou G, Goossens H, Versporten A, Kopsidas J, Kourlaba G, Bielicki J, Drapier N, Zaoutis T, Tsolia M, Sharland M; ARPEC Project Group Members. Variation in paediatric hospital antibiotic guidelines in Europe. Arch Dis Child. 2016 Jan;101(1):72-6.
  • Tamme K, Oselin K, Kipper K, Tasa T, Metsvaht T, Karjagin J, Herodes K, Kern H, Starkopf J. Pharmacokinetics and pharmacodynamics of piperacillin/tazobactam during high volume haemodiafiltration in patients with septic shock. Acta Anaesthesiol Scand. 2016 Feb;60(2):230-40.
  • Vaikjärv R, Kasenõmm P, Jaanimäe L, Kivisild A, Rööp T, Sepp E, Mändar R. Microbiology of peritonsillar abscess in the South Estonian population. Microb Ecol Health Dis. 2016 Apr 22;27:27787.
  • Invention: Vaginal Lactobacillus crispatus strains as probiotics for urogenital health. ; Owners: Competence Centre on Health Technologies; Authors: Reet Mändar, Pirje Hütt, Imbi Smidt, Jelena Štšepetova, Eleri Lapp, Mariheleen Rostok, Gertu Sõerunurk, Tiiu Rööp, Dagmar Hoidmets, Hardi Tamm, Marit Kolk, Sander Piiskop, Triin Palmiste, Kairi Koort, Andres Salumets; Priority number: 1816425.1 ; Priority date: 9.10.2018.
  • Invention: Lactobacillus fermentum ME-3 for use in trating metabolic syndrome related diseases; Owners: University of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine; Authors: Tiiu Kullisaar, Mihkel Zilmer, Imbi Smidt, Kersti Zilmer, Marika Mikelsaar, Pirje Hütt; Priority number: EP2943210B1; Priority date: 10.01.2018.
  • Invention: Method of treatment using Lactobacillus fermentum ME-3; Owners: University of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine; Authors: Tiiu Kullisaar, Mihkel Zilmer, Imbi Smidt, Kersti Zilmer, Marika Mikelsaar, Pirje Hütt; Priority number: WO2013IB61216 20131220; GB20120023370 20121224; Priority date: 14.09.2015.
  • Invention: Strain of micro-organism lactobacillus fermentum ME-3 as novel anti-microbal and anti-oxidative probiotic; Owners: University of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine; Authors: Marika Mikelsaar, Mihkel Zilmer, Epp Songisepp, Tiiu Kullisaar, Heidi Annuk; Priority number: P200100356; Priority date: 29.06.2001.
  • Invention: Isolated microorganism strains Lactobacillus plantarum MCC1 DSM 23881 and Lactobacillus gasseri MCC2 DSM 23882 and their use; Owners: Tervisliku Piima Biotehnoloogiate Arenduskeskus OÜ; Authors: Epp Songisepp, Lauri Bobrovski, Kersti Ehrlich-Peets, Marika Mikelsaar, Tiiu Kullisaar, Mihkel Zilmer, Ene Tammsaar, Andre Veskioja, Kersti Zilmer, Merle Rätsep, Margus Punab, Maire Vasar; Priority number: EE201100012; Priority date: 25.02.2011.
  • Invention: Isolated Lactobacillus plantarum strain Inducia DSM 21379 as probiotic that enhances natural immunity and food products and medicinal preparations comprising it; Owners: BioCC LLC; Authors: Epp Songisepp, Jelena Stsepetova, Kalle Kilk, Marika Mikelsaar, Imbi Smidt, Pirje Hütt, Mihkel Zilmer, Kai Truusalu; Priority number: EE05341; Priority date: 13.05.2008.
  • Invention: "Isolated Lactobacillus plantarum strain Inducia DSM 21379 as probiotic that enhances natural immunity and food products and medicinal preparations comprising it" ; Owners: BioCC OÜ; Authors: Marika Mikelsaar, Imbi Smidt, Jelena Stsepetova, Mihkel Zilmer, Pirje Hütt, Kai Truusalu, Kalle Kilk; Priority number: P200800027; Priority date: 13.05.2008.
  • Invention: "Isolated microorganism strain Lactobacillus plantarum Tensia DSM 21380 as antimicrobial and antihypertensive probiotic, food product and composition comprising said microorganism and use of said microorganism for preparation of antihypertensive medicine and method for suppressing pathogens and non-starter lactobacilli in food product"; Owners: BioCC OÜ; Authors: Marika Mikelsaar, Merle Rätsep, Mihkel Zilmer, Pirje Hütt, Kersti Zilmer, Janne Üksti, Siiri Kõljalg; Priority number: P200800026; Priority date: 13.05.2008.
  • Invention: "Isolated microorganism strain Lactobacillus plantarum Inducia DSM 21379 as probiotic enhancing natural immunity of organism, food product and composition comprising said microorganism and use of said microorganism for production of medicine for enhancing of cellular immunity"; Owners: Tervisliku Piima Biotehnoloogiate Arenduskeskus OÜ; Authors: Marika Mikelsaar, Epp Songisepp, Imbi Smidt, Jelena Stsepetova, Pirje Hütt, Mihkel Zilmer, Kai Truusalu, Kalle Kilk; Priority number: PCT/EE2009/000006; Priority date: 13.05.2008.
  • Invention: Composition comprising a probiotic microorganism strain Lactobacillus plantarum Inducia DSM 21379 as hypocholesterolemic and antimicrobial agent for use in preventing cardiovascular disorders Clostridium difficile associated diarrhoea ; Owners: BioCC LLC; Authors: Marika Mikelsaar, Epp Songisepp, Merle Rätsep, Pirje Hütt, Imbi Smidt, Kai Truusalu, Epp Sepp, Raik-Hiio Mikelsaar, Kalle Kilk, Jelena Štšepetova, Siiri Kõljalg, Mirjam Vallas; Priority number: US201414244284 20140403; Priority date: 16.11.2015.
  • Invention: Lactobacillus plantarum INDUCIA strain DSM 21379 as hypocholesterolemic agent and antimicrobial agent against Clostridium difficile; Owners: Tervisliku Piima Biotehnoloogiate Arenduskeskus OÜ; Authors: Epp Songisepp, Jelena Stsepetova, Siiri Kõljalg, Marika Mikelsaar, Merle Rätsep, Mirjam Vallas, Pirje Hütt, Imbi Smidt, Kai Truusalu, Epp Sepp, Raik-Hiio Mikelsaar, Kalle Kilk; Priority number: P201400038; Priority date: 30.07.2014.
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