Reseach of the Laboratory of Precision and Nanomedicine

Grants

• Estonian Research Council: LDL-like nanoparticles for CAR-T-based glioblastoma immunotherapy (SMVBS21620, 13.12.2021−12.12.2024)
• Bill and Melinda Gates Foundation: Peptide-targeted nanoparticles for delivery of therapeutics to tuberculosis (MMVBS21410, 07.04.2021−30.04.2025)
• European Commission: Project: Hemoglobin based Protein Nanocarriers for Tumour Oxygenation and a more effective Photodynamic Therapy (MMVBS18435R, 01.03.2019−31.08.2024)
• Estonian Research Council: Precision targeting of infiltrative glioblastoma (GMVBS23048PR, 01.01.2023−31.12.2027)
• USA: Macrophage-targeting Nanoplatforms as Immunotherapy against Pulmonary Infections (MMVBS24156, 11.01.2024−30.11.2024)

The most important publications in last five years

1. Paclitaxel-Loaded Cationic Fluid Lipid Nanodiscs and Liposomes with Brush-Conformation PEG Chains Penetrate Breast Tumors and Trigger Caspase-3 Activation. Simón-Gracia L, Scodeller P, Fisher WS, Sidorenko V, Steffes VM, Ewert KK, Safinya CR, Teesalu T.ACS Appl Mater Interfaces. 2022 Dec 28;14(51):56613-56622. doi: 10.1021/acsami.2c17961. Epub 2022 Dec 15.PMID: 36521233
2. Novel Anthracycline Utorubicin for Cancer Therapy.Simón-Gracia L, Sidorenko V, Uustare A, Ogibalov I, Tasa A, Tshubrik O, Teesalu T. Angew Chem Int Ed Engl. 2021 Jul 26;60(31):17018-17027. doi: 10.1002/anie.202016421. Epub 2021 Jun 1. PMID: 33908690
3. In vivo phage display: identification of organ-specific peptides using deep sequencing and differential profiling across tissues.Pleiko K, Põšnograjeva K, Haugas M, Paiste P, Tobi A, Kurm K, Riekstina U, Teesalu T. Nucleic Acids Res. 2021 Apr 19;49(7):e38. doi: 10.1093/nar/gkaa1279. PMID: 33444445
4. A widespread viral entry mechanism: The C-end Rule motif-neuropilin receptor interaction. Balistreri G, Yamauchi Y, Teesalu T. Proc Natl Acad Sci U S A. 2021 Nov 16;118(49):e2112457118. doi: 10.1073/pnas.2112457118. PMID: 34772761
5. Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Cantuti-Castelvetri L, Ojha R, Pedro LD, Djannatian M, Franz J, Kuivanen S, van der Meer F, Kallio K, Kaya T, Anastasina M, Smura T, Levanov L, Szirovicza L, Tobi A, Kallio-Kokko H, Österlund P, Joensuu M, Meunier FA, Butcher SJ, Winkler MS, Mollenhauer B, Helenius A, Gokce O, Teesalu T, Hepojoki J, Vapalahti O, Stadelmann C, Balistreri G, Simons M. Science. 2020 Nov 13;370(6518):856-860. doi: 10.1126/science.abd2985. Epub 2020 Oct 20. PMID: 33082293