Publications of the Department of Immunology

2023

Krigul AA, juhendaja Uibo R. Uni ja immuunsus. Eesti Arst 2023;102(9):464–469.
Kelder M, Vorobjova T. Peensoole barjääri läbilaskvus, seda mõjutada võivad tegurid ja selle määramise meetodid. Eesti Arst 2023;102(9):470–477.
Bonroy C, Vercammen M, Fierz W, Andrade LEC, Van Hoovels L, Infantino M, Fritzler MJ, Bogdanos D, Kozmar A, Nespola B, Broeders S, Patel D, Herold M, Zheng B, Chan EYT, Uibo R, Haapala AM, Musset L, Sack U, Nagy G, Sundic T, Fischer K, Rego de Sousa MJ, Vargas ML, Eriksson C, Heijnen I, García-De La Torre I, Carballo OG, Satoh M, Kim KH, Chan EKL, Damoiseaux J, Lopez-Hoyos M, Bossuyt X; European Federation of Laboratory Medicine (EFLM) Working Group “Autoimmunity Testing,” the European Autoimmune Standardization Initiative (EASI) and International Consensus on Antinuclear Antibody Patterns (ICAP). Detection of antinuclear antibodies: recommendations from EFLM, EASI and ICAP. Clin Chem Lab Med. 2023 Mar 29. doi: 10.1515/cclm-2023-0209. Online ahead of print. PMID: 36989417
Oras A, Kallionpää H, Suomi T, Koskinen S, Laiho A, Elo LL, Knip M, Lahesmaa R, Aints A, Uibo R; DIABIMMUNE Study Group. Profiling of peripheral blood B-cell transcriptome in children who developed coeliac disease in a prospective study. Heliyon. 2023 Jan 21;9(2):e13147. doi: 10.1016/j.heliyon.2023.e13147. eCollection 2023 Feb. PMID: 36718152
Grace SL, Mortimer GL, Kozhakhmetova A, Leveret J, Newton R, Reimand K, Shield JPH, Uibo R, Williams AJK, Gillespie KM. Increased levels of anti-BSA antibodies in children with Down syndrome. Front. Endocrinol., 03 February 2023, Vol 14. doi.org/10.3389/fendo.2023.1056925
Ergür E, Ergür E, Alnek K, Metsküla K, Peet A, Lubi M, Heilman K, Uibo R. Clinical signs of type 1 diabetes are associated with type 2 diabetes marker transcription factor 7-like 2 polymorphism. J Diabetes Investig. 2023 Feb;14(2):221-229. doi: 10.1111/jdi.13933. Epub 2022 Oct 27. PMID: 36300877

Uhlinova J, Kuudeberg A, Metsküla K, Lember M, Rosenberg M. Significant associations between bone mineral density and vascular calcification in patients with different stages of chronic kidney disease. BMC Nephrol. 2022 Oct 5;23(1):327. doi: 10.1186/s12882-022-02955-9. PMID: 36199013
Laidmäe I, Aints A, Uibo R. Growth of MIN-6 Cells on Salmon Fibrinogen Scaffold Improves Insulin Secretion. Pharmaceutics Volume 14, Issue 5, 10.3390/pharmaceutics14050941.
Vorobjova T, Tagoma A, Talja I, Janson H, Kirss A, Uibo R. FABP4 and I-FABP Levels in Pregnant Women Are Associated with Body Mass Index but Not Gestational Diabetes. Journal of Diabetes Research 2022, Volume 2022, Article ID 1089434, https://doi.org/10.1155/2022/1089434.
Tagoma A, Haller-Kikkatalo K, Oras A, Roos K, Kirss A, Uibo R. Plasma cytokines during pregnancy provide insight into the risk of diabetes in the gestational diabetes risk group. J Diabetes Investig. 2022 May 7. doi: 10.1111/jdi.13828. Online ahead of print.
Salumets A, Tserel L, Rumm AP, Türk L, Kingo K, Saks K, Oras A, Uibo R, Tamm R, Peterson H, Kisand K, Peterson P. Epigenetic quantification of immunosenescent CD8+ TEMRA cells in human blood. Aging Cell. 2022 Apr 9:e13607. doi: 10.1111/acel.13607. Aging Cell. 2022 May;21(5):e13607. doi: 10.1111/acel.13607. Epub 2022 Apr 9.
Štšepetova J, Simre K, Tagoma A, Uibo O, Peet A, Siljander H, Tillmann V, Knip M, Mändar R, Uibo R. Maternal breast milk microbiota and immune markers in relation to subsequent development of celiac disease in offspring. Sci Rep. 2022 Apr 22;12(1):6607. doi: 10.1038/s41598-022-10679-x.
Reinert-Hartwall L, Siljander H, Härkönen T, Vatanen T, Ilonen J, Niemelä O, Luopajärvi K, Dorshakova N, Mokurov S, Peet A, Tillmann V, Uibo R, Knip M, Vaarala O, Honkanen J; DIABIMMUNE study group. Higher circulating EGF levels associate with a decreased risk of IgE sensitization in young children. Pediatr Allergy Immunol. 2022 Jan;33(1):e13613. doi: 10.1111/pai.13613. Epub 2021 Aug 17.
Pervjakova N, Moen GH, Borges MC, Ferreira T, Cook JP, Allard C, Beaumont RN, Canouil M, Hatem G, Heiskala A, Joensuu A, Karhunen V, Kwak SH, Lin FTJ, Liu J, Rifas-Shiman S, Tam CH, Tam WH, Thorleifsson G, Andrew T, Auvinen J, Bhowmik B, Bonnefond A, Delahaye F, Demirkan A, Froguel P, Haller-Kikkatalo K, Hardardottir H, Hummel S, Hussain A, Kajantie E, Keikkala E, Khamis A, Lahti J, Lekva T, Mustaniemi S, Sommer C, Tagoma A, Tzala E, Uibo R, Vääräsmäki M, Villa PM, Birkeland KI, Bouchard L, Duijn CM, Finer S, Groop L, Hämäläinen E, Hayes GM, Hitman GA, Jang HC, Järvelin MR, Jenum AK, Laivuori H, Ma RC, Melander O, Oken E, Park KS, Perron P, Prasad RB, Qvigstad E, Sebert S, Stefansson K, Steinthorsdottir V, Tuomi T, Hivert MF, Franks PW, McCarthy MI, Lindgren CM, Freathy RM, Lawlor DA, Morris AP, Mägi R. Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes. Hum Mol Genet. 2022 Feb 26:ddac050. doi: 10.1093/hmg/ddac050. Online ahead of print.

Šunina M, Alnek K, Kisand Kai, Uibo R. Human CD4+ and CD8+ T lymphocyte subpopulations have significantly different surface expression patterns of CD226 and TIGIT molecules. Scandinavian Journal of Immunology September 2021 Volume 94, Issue 3. First published 23 June 2021.
Ruohtula T, Kondrashova A, Lehtonen J, Oikarinen S, Hämäläinen AM, Niemelä O, Peet A, Tillmann V, Nieminen JK, Ilonen J, Knip M, Vaarala O, Hyöty H; DIABIMMUNE Study Group (2021). Immunomodulatory Effects of Rhinovirus and Enterovirus Infections During the First Year of Life. Front Immunol. 2021 Feb 11;11:567046. doi: 10.3389/fimmu.2020.567046. eCollection 2020.

Oras A, Quirani-Sanchez B, Popadic D, Thunberg S, Winqvist O, heck S, Cwikowski M, Riemann D, Seliger B, Caceres EM, Uibo R, Giese T (2020): Comprehensive flow cytometric reference values of leukocyte subsets from six study centers across Europe. Clin Exp Immunol. 2020 Jul 12. doi: 10.1111/cei.13491. Online ahead of print.
Sack U, Bossuyt X, Andreeva H, Antal-Szalmás P, Bizzaro N, Bogdanos D.P, Borzova E, Conrad K, Dragon-Durey M, Eriksson C, Fischer K, Haapala, A. Heijnen I, Herold M, Klotz W, Kuna AT, Lopez Hoyos M, Malkov VA, Musset L, Nagy E, Rönnelid J, Shoenfeld Y, Sundic T, Tsirogianni A, Uibo R, Rego de Sousa MJ, Damoisseaux J (2020): Quality and best practice in medical laboratories: specific requests for autoimmunity testing. Autoimmunity Highlights 11; Article no. 12. DOI: 10.1186/s13317-020-00134-0.
Mustonen N, Siljander H, Peet A, Tillmann V, Härkönen T, Niemelä O, Uibo R, Ilonen J, Knip M DIABIMMUNE Study Group (2020): Coeliac disease and HLA-conferred susceptibility to autoimmunity are associated with IgE sensitization in young children. Allergy. 2020 Mar;75(3):692-694. doi: 10.1111/all.14055. Epub 2019 Oct 2.
Aunap S, Metsküla K, Uibo R (2020): ANAd – tuumaantikehad kui olulisim grupp diagnostilise väärtusega autoantikehi. Eest Arst; 99: 289–295.

Tagoma A, Haller-Kikkatalo K, Roos K, Oras A, Kirss A, Ilonen J, Uibo R. Interleukin-7, T helper 1, and regulatory T-cell activity-related cytokines are increased during the second trimester of healthy pregnancy compared to non-pregnant women. Am J Reprod Immunol. 2019 Dec;82(6):e13188. doi: 10.1111/aji.13188. Epub 2019 Sep 28.
Lampasona V, Pittman DL, Williams AJ, Achenbach P, Schlosser M, Akolkar B, Winter WE; Participating Laboratories. Islet Autoantibody Standardization Program 2018 Workshop: Interlaboratory Comparison of Glutamic Acid Decarboxylase Autoantibody Assay Performance. Clin Chem. 2019 Sep;65(9):1141-1152. doi: 10.1373/clinchem.2019.304196. Epub 2019 Aug 13.
Mustonen N, Siljander H, Peet A, Tillmann V, Härkönen T, Ilonen J, Hyöty H, Knip M; DIABIMMUNE Study Group. Early childhood infections and the use of antibiotics and antipyretic-analgesics in Finland, Estonia, and Russian Karelia. Acta Paediatr. 2019 Nov;108(11):2075-2082. doi: 10.1111/apa.14874. Epub 2019 Jun 23.
Vorobjova T, Tagoma A, Oras A, Alnek K, Kisand K, Talja I, Uibo O, Uibo R. Celiac Disease in Children, Particularly with Accompanying Type 1 Diabetes, Is Characterized by Substantial Changes in the Blood Cytokine Balance, Which May Reflect Inflammatory Processes in the Small Intestinal Mucosa. J Immunol Res. 2019 May 12;2019:6179243. doi: 10.1155/2019/6179243. eCollection 2019.
Oras A, Peet A, Giese T, Tillmann V, Uibo R. A study of 51 subtypes of peripheral blood immune cells in newly diagnosed young type 1 diabetes patients. Clin Exp Immunol. 2019 Oct;198(1):57-70. doi: 10.1111/cei.13332. Epub 2019 Jun 21.
Simre K, Uibo O, Peet A, Puustinen L, Oikarainen S, Tamminen K, Blazevic V, Tillmann V, Hämäläinen AM, Härkönen T, Siljander H, Virtanen SM, Ilonen J, Hyöty H, Knip M, Uibo R; DIABIMMUNE Study Group. Early life exposure to common virus infections did not differ between coeliac disease patients and controls. Acta Paediatr. 2019 Sep;108(9):1709-1716. doi: 10.1111/apa.14791. Epub 2019 Apr 11.
Orro E, Alnek K, Reimand T, Reimand K, Uibo O, Talvik T, Haller-Kikkatalo K, Kisand K, Uibo R. Patients with down syndrome have increased prevalence of rheumatoid factor but not autoantibodies to anti-cyclic citrullinated peptide. Clin Chim Acta. 2019 Aug;495:40-42. doi: 10.1016/j.cca.2019.03.1614. Epub 2019 Mar 16.
Vatanen T, Plichta DR, Somani J, Münch PC, Arthur TD, Hall AB, Rudolf S, Oakeley EJ, Ke X, Young RA, Haiser HJ, Kolde R, Yassour M, Luopajärvi K, Siljander H, Virtanen SM, Ilonen J, Uibo R, Tillmann V, Mokurov S, Dorshakova N, Porter JA, McHardy AC, Lähdesmäki H, Vlamakis H, Huttenhower C, Knip M, Xavier RJ. Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life. Nat Microbiol. 2019 Mar;4(3):470-479. doi: 10.1038/s41564-018-0321-5. Epub 2018 Dec 17. Erratum in: Nat Microbiol. 2019 Feb 5.

Nieminen HJ, Laidmäe I, Salmi A, Rauhala T, Paulin T, Heinämäki J, Hæggström E. Ultrasound-enhanced electrospinning. Sci Rep. 2018 Mar 13;8(1):4437. doi: 10.1038/s41598-018-22124-z.
Laidmäe I, Ērglis K, Cēbers A, Janmey PA, Uibo R. Salmon fibrinogen and chitosan scaffold for tissue engineering: in vitro and in vivo evaluation. J Mater Sci Mater Med. 2018 Nov 30;29(12):182. doi: 10.1007/s10856-018-6192-8.
Raam L, Kaleviste E, Šunina M, Vaher H, Saare M, Prans E, Pihlap M, Abram K, Karelson M, Peterson P, Rebane A, Kisand K, Kingo K. Lymphoid Stress Surveillance Response Contributes to Vitiligo Pathogenesis. Front Immunol. 2018 Nov 20;9:2707. doi: 10.3389/fimmu.2018.02707. eCollection 2018.
Šunina M, Kaleviste E, Uibo R, Kisand K. Unstimulated Adult Human B Cells Include an IL-10+ Population with Suppressive Properties and an Activated Phenotype. Cytometry A. 2018 Nov;93(11):1150-1156. doi: 10.1002/cyto.a.23636. Epub 2018 Oct 21.
Tagoma A, Alnek K, Kirss A, Uibo R, Haller-Kikkatalo K. MicroRNA profiling of second trimester maternal plasma shows upregulation of miR-195-5p in patients with gestational diabetes. Gene. 2018 Sep 25;672:137-142. doi: 10.1016/j.gene.2018.06.004. Epub 2018 Jun 4.
Parkkola A, Härkönen T, Ryhänen SJ, Uibo R, Ilonen J, Knip M; and the Finnish Pediatric Diabetes Register. Transglutaminase antibodies and celiac disease in children with type 1 diabetes and in their family members. Pediatr Diabetes. 2018 Mar;19(2):305-313. doi: 10.1111/pedi.12563. Epub 2017 Jul 26.
Maire Link, Raivo Uibo. Alfa-gal-vastased IgE-tüüpi antikehad ja lihaallergia. Eesti Arst 2018; 97(11):607–608.

Hyytinen M, Savilahti E, Virtanen SM, Härkönen T, Ilonen J, Luopajärvi K, Uibo R, Vaarala O, Åkerblom HK, Knip M; Finnish TRIGR Pilot Study Group. Avoidance of Cow's Milk-based Formula for At-risk Infants Does Not Reduce Development of Celiac Disease: a Randomized Controlled Trial. Jul 4. pii: Gastroenterology. 2017 Oct;153(4):961-970.e3. doi: 10.1053/j.gastro.2017.06.049. Epub 2017 Jul 5.
Haller-Kikkatalo K, Alnek K, Metspalu A, Mihailov E, Metsküla K, Kisand K, Pisarev H, Salumets A, Uibo R. Demographic associations for autoantibodies in disease-free individuals of a European population. Sci Rep. 2017 Mar 28;7:44846. doi: 10.1038/srep44846.
Vorobjova T, Raikkerus H, Kadaja L, Talja I, Uibo O, Heilman K, Uibo R. Circulating Zonulin Correlates with Density of Enteroviruses and Tolerogenic Dendritic Cells in the Small Bowel Mucosa of Celiac Disease Patients. Dig Dis Sci. 2017 Feb;62(2):358-371. doi: 10.1007/s10620-016-4403-z. Epub 2016 Dec 19.
Mihklepp K, Kivirand K, Nikopensius M, Peedel D, Utt M, Rinken T. Design and production of antibodies for the detection of Streptococcus uberis. Enzyme Microb Technol. 2017 Jan;96:135-142. doi: 10.1016/j.enzmictec.2016.10.009. Epub 2016 Oct 17.
Simre K, Uibo O, Tillmann V, Knip M, Uibo R. Reply to "Antibiotics, intestinal dysbiosis and risk of celiac disease" by Hakim Rahmoune et al. Dig Liver Dis. 2017 Jan;49(1):106-107. doi: 10.1016/j.dld.2016.10.009. Epub 2016 Oct 25.
Šahmatova L, Sügis E, Šunina M, Hermann H, Prans E, Pihlap M, Abram K, Rebane A, Peterson H, Peterson P, Kingo K, Kisand K. Signs of innate immune activation and premature immunosenescence in psoriasis patients. Sci Rep. 2017 Aug 8;7(1):7553. doi: 10.1038/s41598-017-07975-2.
Kristine Roos, Aili Tagoma, Anne Kirss, Raivo Uibo, Kadri Haller-Kikkatalo. Vereseerumi D-vitamiini sisaldus raseduse teisel kolmandikul mõjutab rasedustulemust ja ema tervist. Eesti Arst 2017; 96(2):81–91.
Viljar Jaks, Raivo Uibo. Autoantikehad täppismeditsiinis. Eesti Arst 2017; 96(2):99–106.
Maaroos H-I, Mikelsaar M, Vorobjova T. Helicobacter pylori avastamise lugu: kliinilised, immunoloogilised ja mikrobioloogilised aspektid. Eesti uurijate panus Nobeli auhinnaga pärjatud uuringutesse. Tartu Ülikooli ajaloo küsimusi. Muutuste sajand Eesti meditsiinis. Tartu Ülikooli muuseum 2017, 45, 76-101.

Simre K, Uibo O, Peet A, Tillmann V, Kool P, Hämäläinen AM, Härkönen T, Siljander H, Virtanen S, Ilonen J, Knip M, Uibo R; DIABIMMUNE Study Group. Exploring the risk factors for differences in the cumulative incidence of coeliac disease in two neighboring countries: the prospective DIABIMMUNE study. Dig Liver Dis. 2016 Nov;48(11):1296-1301. doi: 10.1016/j.dld.2016.06.029. Epub 2016 Jul 6.
Tšuiko O, Nõukas M, Žilina O, Hensen K, Tapanainen JS, Mägi R, Kals M, Kivistik PA, Haller-Kikkatalo K, Salumets A, Kurg A. Copy number variation analysis detects novel candidate genes involved in follicular growth and oocyte maturation in a cohort of premature ovarian failure cases. Hum Reprod. 2016 Aug;31(8):1913-25. doi: 10.1093/humrep/dew142. Epub 2016 Jun 14.
Meyer S, Woodward M, Hertel C, Vlaicu P, Haque Y, Kärner J, Macagno A, Onuoha SC, Fishman D, Peterson H, Metsküla K, Uibo R, Jäntti K, Hokynar K, Wolff AS; APECED patient collaborative, Krohn K, Ranki A, Peterson P, Kisand K, Hayday A. AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies. Cell. 2016 Jul 28;166(3):582-595. doi: 10.1016/j.cell.2016.06.024. Epub 2016 Jul 14.
Vorobjova T, Ress K, Luts K, Uibo O, Uibo R. The impact of langerin (CD207)+ dendritic cells and FOXP3+ Treg cells in the small bowel mucosa of children with celiac disease and atopic dermatitis in comparison to children with functional gastrointestinal disorders. APMIS. 2016 Aug;124(8):689-96. doi: 10.1111/apm.12552. Epub 2016 May 20.
Vatanen T, Kostic AD, d'Hennezel E, Siljander H, Franzosa EA, Yassour M, Kolde R, Vlamakis H, Arthur TD, Hämäläinen AM, Peet A, Tillmann V, Uibo R, Mokurov S, Dorshakova N, Ilonen J, Virtanen SM, Szabo SJ, Porter JA, Lähdesmäki H, Huttenhower C, Gevers D, Cullen TW, Knip M; DIABIMMUNE Study Group, Xavier RJ. Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans. Cell. 2016 May 5;165(4):842-53. doi: 10.1016/j.cell.2016.04.007. Epub 2016 Apr 28. Erratum in: Cell. 2016 Jun 2;165(6):1551.
Haller-Kikkatalo K, Uibo R. Clinical Recommendations for the Use of Islet Cell Autoantibodies to Distinguish Autoimmune and Non-Autoimmune Gestational Diabetes. Clin Rev Allergy Immunol. 2016 Feb;50(1):23-33. doi: 10.1007/s12016-014-8461-8.
Suutre, Siim; Kerna, Irina; Kisand, Kalle; Aunapuu, Marina; Arend, Andres; Tamm, Agu (2016). Immunohistochemical detection of cartilage intermediate layer protein 1 in the synovial membrane of patients with knee complaints. Int J Clin Exp Pathol, 9 (8), 8386−8390.
Kallas E, Huik K, Türk S, Pauskar M, Jõgeda EL, Šunina M, Karki T, Des Jarlais D, Uusküla A, Avi R, Lutsar I. T Cell Distribution in Relation to HIV/HBV/HCV Coinfections and Intravenous Drug Use. Viral Immunol. 2016 Oct;29(8):464-470. Epub 2016 Aug 26.
Kallas E, Huik K, Türk S, Pauskar M, Jõgeda EL, Šunina M, Karki T, Des Jarlais D, Uusküla A, Avi R, Lutsar I. Differences in T cell distribution and CCR5 expression in HIV-positive and HIV-exposed seronegative persons who inject drugs. Med Microbiol Immunol. 2016 Jun;205(3):231-9. doi: 10.1007/s00430-015-0444-8. Epub 2015 Dec 22.
Maris Niibek, Annabel Kongi. Miks rinnapiim on kasulik? Eesti Arst 2016; 95(4):233–241 Juhendaja K. Haller-Kikkatalo.
Siiri Paiste, Tamara Vorobjova, Ken Kalling, Raivo Uibo. Meditsiiniline immunoloogia Eestis. Arengutendentse ja saavutusi kuni 1980. aastateni. Eesti Arst 2016; 95(8):523–529.
Tiia-Linda Okas, Raivo Uibo. Loomuliku immuunsuse lümfoidrakud laiendavad meie teadmisi immuunsüsteemi toimimisest. Eesti Arst 2016; 95(1):28–31.

Publications of the Department of Immunology

2023

2022

2021

2020

2019

2018

2017

2016