Publications and patents of the Laboratory of Precision and Nanomedicine

24.11.2021
#research

2022

  • Simón-Gracia L, Scodeller P, Fisher WS, Sidorenko V, Steffes VM, Ewert KK, Safinya CR, Teesalu T. Paclitaxel-Loaded Cationic Fluid Lipid Nanodiscs and Liposomes with Brush-Conformation PEG Chains Penetrate Breast Tumors and Trigger Caspase-3 Activation. ACS Appl Mater Interfaces. 2022 Dec 28;14(51):56613-56622. doi: 10.1021/acsami.2c17961. Epub 2022 Dec 15. PubMed PMID: 36521233; PubMed Central PMCID: PMC9879205.
  • Saccon TD, Mousovich-Neto F, Ludwig RG, Carregari VC, Dos Anjos Souza AB, Dos Passos ASC, Martini MC, Barbosa PP, de Souza GF, Muraro SP, Forato J, Amorim MR, Marques RE, Veras FP, Barreto E, Gonçalves TT, Paiva IM, Fazolini NPB, Onodera CMK, Martins Junior RB, de Araújo PHC, Batah SS, Viana RMM, de Melo DM, Fabro AT, Arruda E, Queiroz Cunha F, Cunha TM, Pretti MAM, Smith BJ, Marques-Souza H, Knittel TL, Ruiz GP, Profeta GS, Fontes-Cal TCM, Boroni M, Vinolo MAR, Farias AS, Moraes-Vieira PMM, Bizzacchi JMA, Teesalu T, Chaim FDM, Cazzo E, Chaim EA, Proença-Módena JL, Martins-de-Souza D, Osako MK, Leiria LO, Mori MA. SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner. Nat Commun. 2022 Sep 29;13(1):5722. doi: 10.1038/s41467-022-33218-8. PubMed PMID: 36175400; PubMed Central PMCID: PMC9521555.
  • Simonetti B, Daly JL, Simón-Gracia L, Klein K, Weeratunga S, Antón-Plágaro C, Tobi A, Hodgson L, Lewis PA, Heesom KJ, Shoemark DK, Davidson AD, Collins BM, Teesalu T, Yamauchi Y, Cullen PJ. ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1. Proc Natl Acad Sci U S A. 2022 Jun 21;119(25):e2201980119. doi: 10.1073/pnas.2201980119. Epub 2022 Jun 13. PubMed PMID: 35696571; PubMed Central PMCID: PMC9231623.
  • Simón-Gracia L, Loisel S, Sidorenko V, Scodeller P, Parizot C, Savier E, Haute T, Teesalu T, Rebollo A. Preclinical Validation of Tumor-Penetrating and Interfering Peptides against Chronic Lymphocytic Leukemia. Mol Pharm. 2022 Mar 7;19(3):895-903. doi: 10.1021/acs.molpharmaceut.1c00837. Epub 2022 Feb 3. PubMed PMID: 35113575.
  • Kurrikoff K, Teesalu T. Editorial on Special Issue "Precision Delivery of Drugs and Imaging Agents with Peptides". Pharmaceutics. 2022 Feb 23;14(3). doi: 10.3390/pharmaceutics14030486. PubMed PMID: 35335863; PubMed Central PMCID: PMC8950749.
  • Põšnograjeva K, Pleiko K, Haugas M, Teesalu T. New Tools for Streamlined In Vivo Homing Peptide Identification. Methods Mol Biol. 2022;2383:385-412. doi: 10.1007/978-1-0716-1752-6_25. PubMed PMID: 34766303.
  • Renshall LJ, Beards F, Evangelinos A, Greenwood SL, Brownbill P, Stevens A, Sibley CP, Aplin JD, Johnstone ED, Teesalu T, Harris LK. Targeted Delivery of Epidermal Growth Factor to the Human Placenta to Treat Fetal Growth Restriction. Pharmaceutics. 2021 Oct 25;13(11):1778. doi: 10.3390/pharmaceutics13111778. PMID: 34834193
  • Balistreri G, Yamauchi Y, Teesalu T. Proc Natl Acad Sci U S A. A widespread viral entry mechanism: The C-end Rule motif-neuropilin receptor interaction. 2021 Nov 16;118(49):e2112457118. doi: 10.1073/pnas.2112457118. PMID: 34772761
  • Põšnograjeva K, Pleiko K, Haugas M, Teesalu T. New Tools for Streamlined In Vivo Homing Peptide Identification. Methods Mol Biol. 2022;2383:385-412. doi: 10.1007/978-1-0716-1752-6_25. PMID: 34766303
  • Savier E, Simon-Gracia L, Charlotte F, Tuffery P, Teesalu T, Scatton O, Rebollo A. Pharmaceutics. Bi-Functional Peptides as a New Therapeutic Tool for Hepatocellular Carcinoma. 2021 Oct 6;13(10):1631. doi: 10.3390/pharmaceutics13101631. PMID: 34683924
  • Ewert KK, Scodeller P, Simón-Gracia L, Steffes VM, Wonder EA, Teesalu T, Safinya CR. Cationic Liposomes as Vectors for Nucleic Acid and Hydrophobic Drug Therapeutics. Pharmaceutics. 2021 Aug 30;13(9):1365. doi: 10.3390/pharmaceutics13091365. PMID: 34575441
  • Rousso-Noori L, Mastandrea I, Talmor S, Waks T, Globerson Levin A, Haugas M, Teesalu T, Alvarez-Vallina L, Eshhar Z, Friedmann-Morvinski D. P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas. Nat Commun. 2021 Jun 14;12(1):3615. doi: 10.1038/s41467-021-23817-2. PMID: 34127674
  • Simón-Gracia L, Sidorenko V, Uustare A, Ogibalov I, Tasa A, Tshubrik O, Teesalu T. Novel Anthracycline Utorubicin for Cancer Therapy. Angew Chem Int Ed Engl. 2021 Jul 26;60(31):17018-17027. doi: 10.1002/anie.202016421. Epub 2021 Jun 1. PMID: 33908690
  • Hurtado de Mendoza T, Mose ES, Botta GP, Braun GB, Kotamraju VR, French RP, Suzuki K, Miyamura N, Teesalu T, Ruoslahti E, Lowy AM, Sugahara KN. Tumor-penetrating therapy for β5 integrin-rich pancreas cancer. Nat Commun. 2021 Mar 9;12(1):1541. doi: 10.1038/s41467-021-21858-1.
  • d'Avanzo N, Torrieri G, Figueiredo P, Celia C, Paolino D, Correia A, Moslova K, Teesalu T, Fresta M, Santos HA. LinTT1 peptide-functionalized liposomes for targeted breast cancer therapy. Int J Pharm. 2021 Mar 15;597:120346. doi: 10.1016/j.ijpharm.2021.120346. Epub 2021 Feb 2. PMID: 33545283
  • Lingasamy P, Teesalu T. Homing Peptides for Cancer Therapy. Adv Exp Med Biol. 2021;1295:29-48. doi: 10.1007/978-3-030-58174-9_2.
  • Pleiko K, Põšnograjeva K, Haugas M, Paiste P, Tobi A, Kurm K, Riekstina U, Teesalu T (2021). In vivo phage display: identification of organ-specific peptides using deep sequencing and differential profiling across tissues. Nucleic Acids Res. 2021 Jan 14, Online ahead of print. PMID: 33444445. DOI: 10.1093/nar/gkaa12795. Epub 2020 Oct 20
  • Ludovico Cantuti-Castelvetri, Ravi Ojha, Liliana D Pedro, Minou Djannatian, Jonas Franz, Suvi Kuivanen, Franziska van der Meer, Katri Kallio, Tuğberk Kaya, Maria Anastasina, Teemu Smura, Lev Levanov, Leonora Szirovicza, Allan Tobi, Hannimari Kallio-Kokko, Pamela Österlund, Merja Joensuu, Frédéric A Meunier, Sarah J Butcher, Martin Sebastian Winkler, Brit Mollenhauer, Ari Helenius, Ozgun Gokce, Tambet Teesalu, Jussi Hepojoki, Olli Vapalahti, Christine Stadelmann, Giuseppe Balistreri, Mikael Simons (2020). Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science 2020 Nov 13;370(6518):856-860. doi:10.1126/science.abd2985. Epub 2020 Oct 20
  • James L Daly, Boris Simonetti, Katja Klein, Kai-En Chen, Maia Kavanagh Williamson, Carlos Antón-Plágaro, Deborah K Shoemark, Lorena Simón-Gracia, Michael Bauer, Reka Hollandi, Urs F Greber, Peter Horvath, Richard B Sessions, Ari Helenius, Julian A Hiscox, Tambet Teesalu, David A Matthews, Andrew D Davidson, Brett M Collins, Peter J Cullen, Yohei Yamauchi (2020). Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science 2020 Nov 13;370(6518):861-865. doi:10.1126/science.abd3072. Epub 2020 Oct 20
  • Lingasamy P, Laarmann AH, Teesalu T (2020). Tumor penetrating peptide-functionalized Tenascin-C antibody for glioblastoma targeting. Curr Cancer Drug Targets. 2020 Oct 1. doi: 10.2174/1568009620666201001112749. Online ahead of print. PMID: 33001014
  • Figueiredo P, Lepland A, Scodeller P, Fontana F, Torrieri G, Tiboni M, Shahbazi MA, Casettari L, Kostiainen MA, Hirvonen J, Teesalu T, Santos HA (2020). Peptide-guided resiquimod-loaded lignin nanoparticles convert tumor-associated macrophages from M2 to M1 phenotype for enhanced chemotherapy. Acta Biomater. 2020 Oct 2:S1742-7061(20)30561-4. doi: 10.1016/j.actbio.2020.09.038 . Online ahead of print. PMID: 33011297
  • Tobi A, Willmore AA, Kilk K, Sidorenko V, Braun GB, Soomets U, Sugahara KN, Ruoslahti E, Teesalu T (2020). Silver Nanocarriers Targeted with a CendR Peptide Potentiate the Cytotoxic Activity of an Anticancer Drug. Advanced Therapeutics 27 July 2020: 2000097. https://doi.org/10.1002/adtp.202000097. Online ahead of print.
  • Pemmari T, Ivanova L, May U, Lingasamy P, Tobi A, Pasternack A, Prince S, Ritvos O, Makkapati S, Teesalu T, Cairo MS, Järvinen TAH, Liao Y (2020). Exposed CendR Domain in Homing Peptide Yields Skin-Targeted Therapeutic in Epidermolysis Bullosa. Mol Ther. 2020 May 20:S1525-0016(20)30251-3. doi: 10.1016/j.ymthe.2020.05.017. Online ahead of print. PMID: 32497513
  • Lepland A, Asciutto EK, Malfanti A, Simón-Gracia L, Sidorenko V, Vicent MJ, Teesalu T, Scodeller P (2020). Targeting Pro-Tumoral Macrophages in Early Primary and Metastatic Breast Tumors With the CD206-Binding mUNO Peptide. Mol Pharm. 2020 Jun 1. doi: 10.1021/acs.molpharmaceut.0c00226. Online ahead of print. PMID: 32421341
  • Lingasamy P, Tobi A, Kurm K, Kopanchuk S, Sudakov A, Salumäe M, Rätsep T, Asser T, Bjerkvig R, Teesalu T (2020). Tumor-penetrating Peptide for Systemic Targeting of Tenascin-C. Sci Rep. 2020 Apr 2;10(1):5809. doi: 10.1038/s41598-020-62760-y. PMID: 32242067
  • Acharya B, Meka RR, Venkatesha SH, Lees JR, Teesalu T, Moudgil KD (2020). A Novel CNS-homing Peptide for Targeting Neuroinflammatory Lesions in Experimental Autoimmune Encephalomyelitis. Mol Cell Probes. 2020 Jun;51:101530. doi: 10.1016/j.mcp.2020.101530. Epub 2020 Feb 5. PMID: 32035108
  • Torrieri G, Fontana F, Figueiredo P, Liu Z, Ferreira MPA, Talman V, Martins JP, Fusciello M, Moslova K, Teesalu T, Cerullo V, Hirvonen J, Ruskoaho H, Balasubramanian V, Santos HA (2020). Dual-peptide Functionalized Acetalated Dextran-Based Nanoparticles for Sequential Targeting of Macrophages During Myocardial Infarction. Nanoscale. 2020 Jan 28;12(4):2350-2358. doi: 10.1039/c9nr09934d. Epub 2020 Jan 13. PMID: 31930241
  • Mäkilä E, Anton Willmore AM, Yu H, Irri M, Aindow M, Teesalu T, Canham LT, Kolasinski KW, Salonen J (2019). Hierarchical Nanostructuring of Porous Silicon With Electrochemical and Regenerative Electroless Etching. ACS Nano. 2019 Nov 26;13(11):13056-13064. doi: 10.1021/acsnano.9b05740. Epub 2019 Nov
  • Asciutto, Eliana K; Kopanchuk, Sergei; Lepland, Anni; Simón-Gracia, Lorena; Aleman, Carlos; Teesalu, Tambet; Scodeller, Pablo (2019). Phage-Display-Derived Peptide Binds to Human CD206 and Modeling Reveals a New Binding Site on the Receptor. The Journal of Physical Chemistry. B, 123 (9), 1973−1982.10.1021/acs.jpcb.8b11876.
  • Lingasamy, Prakash; Tobi, Allan; Haugas, Maarja; Hunt, Hedi; Paiste, Päärn; Asser, Toomas; Rätsep, Tõnu; Kotamraju, Venkata Ramana; Bjerkvig, Rolf; Teesalu, Tambet (2019). Bi-specific tenascin-C and fibronectin targeted peptide for solid tumor delivery. Biomaterials, 219, 119373.10.1016/j.biomaterials.2019.119373.
  • Säälik, Pille; Lingasamy, Prakash; Toome, Kadri; Mastandrea, Ignacio; Rousso-Noori, Liat; Tobi, Allan; Simón-Gracia, Lorena; Hunt, Hedi; Paiste, Päärn; Kotamraju, Venkata Ramana; Bergers, Gabriele; Asser, Toomas; Rätsep, Tõnu; Ruoslahti, Erkki; Bjerkvig, Rolf; Friedmann-Morvinski, Dinorah; Teesalu, Tambet (2019). Peptide-guided nanoparticles for glioblastoma targeting. Journal of controlled release : official journal of the Controlled Release Society, 308, 109−118.10.1016/j.jconrel.2019.06.018.
  • Karolczak-Bayatti, Magdalena; Forbes, Karen; Horn, James; Teesalu, Tambet; Harris, Lynda K.; Westwood, Melissa; Aplin, John D. (2019). IGF signalling and endocytosis in the human villous placenta in early pregnancy as revealed by comparing quantum dot conjugates with a soluble ligand. Nanoscale, 11 (25), 12285−12295.10.1039/c8nr10337b.
  • Hussain, S.; Joo, J.; Kang, J.; Kim, B.; Braun, G.B.; She, Z.; Kim, D.; Mann, A.P.; Mölder, T.; Teesalu, T.; Carnazza, S.; Guglielmino, S.; Sailor, M.J.; Ruoslahti, E. (2018). Antibiotic-loaded nanoparticles targeted to the site of infection enhance antibacterial efficacy. nature biomedical engineering.10.1038/s41551-017-0187-5.
  • Simón-Gracia, Lorena; Scodeller, Pablo; Salazar Fuentes, Sergio; Gómez Vallejo, Vanessa; Ríos, Xabier; San Sebastián, Eneko; Sidorenko, Valeria; Di Silvio, Desirè; Suck, Meina; De Lorenzi, Federica; Yokota Rizzo, Larissa; von Stillfried, Saskia; Kilk, Kalle; Lammers, Twan; Moya, Sergio E.; Teesalu, Tambet (2018). Application of polymersomes engineered to target p32 protein for detection of small breast tumors in mice. Oncotarget, 9 (27), 18682−18697.10.18632/oncotarget.24588.
  • Emily Wonder, Lorena Simón-Gracia, Pablo Scodeller, Ramsey N. Majzoub, Venkata Ramana Kotamraju, Kai K. Ewert, Tambet Teesalu, Cyrus R. Safinya (2018). Competition of charge-mediated and specific binding by peptide-tagged cationic liposome–DNA nanoparticles in vitro and in vivo. Biomaterials, 166, 52−63.10.1016/j.biomaterials.2018.02.052.
  • Simon-Gracia, Lorena; Hunt, Hedi; Teesalu, Tambet (2018). Peritoneal carcinomatosis targeting with tumor homing peptides. Macromolecules, 23, 1190.10.3390/molecules23051190.
  • Sharma, S.; Kotamraju, V.R.; Mölder, T.; Tobi, A.; Teesalu, T.; Ruoslahti, E. (2017). Tumor-Penetrating Nanosystem Strongly Suppresses Breast Tumor Growth. Nano Letters, 17 (3), 1356−1364.10.1021/acs.nanolett.6b03815.
  • Hunt, H.; Simón-Gracia, L.; Tobi, A.; Kotamraju, V.R.; Sharma, S.; Nigul, M.; Sugahara, K.N.; Ruoslahti, E.; Teesalu, T. (2017). Targeting of p32 in peritoneal carcinomatosis with intraperitoneal linTT1 peptide-guided pro-apoptotic nanoparticles. Journal of Controlled Release, 260 (260), 142−153.10.1016/j.jconrel.2017.06.005.
  • Toome, K.; Willmore, A.A.; Paiste, P.; Tobi, A.; Sugahara, K.N.; Kirsimäe, K.; Ruoslahti, E.; Braun, G.B.; Teesalu, T. (2017). Ratiometric in vivo auditioning of targeted silver nanoparticles. Nanoscale, 9 (28), 10094−10100.10.1039/c7nr04056c.
  • Ikemoto, Hideki; Lingasamy, Prakash; Anton Willmore, Anne-Mari; Hunt, Hedi; Kurm, Kaarel; Tammik, Olav; Scodeller, Pablo; Simón-Gracia, Lorena; Kotamraju, Venkata Ramana; Lowy, Andrew M; Sugahara, Kazuki N; Teesalu, Tambet (2017). Hyaluronan-binding peptide for targeting peritoneal carcinomatosis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 39 (5), 1−9.10.1177/1010428317701628.
  • Sharma, S.; Mann, A.P.; Mölder, T.; Kotamraju, V.R.; Mattrey, R.; Teesalu, T.; Ruoslahti, E. (2017). Vascular changes in tumors resistant to a vascular disrupting nanoparticle treatment. Journal of Controlled Release, 268, 49−56.10.1016/j.jconrel.2017.10.006.
  • Cureton, N.; Korotkova, I.; Baker, B.; Greenwood, S.; Wareing, M.; Kotamraju, V.R.; Teesalu, T.; Cellesi, F.; Tirelli, N.; Ruoslahti, E.; Aplin, JD.; Harris, L.K. (2017). Selective Targeting of a Novel Vasodilator to the Uterine Vasculature to Treat Impaired Uteroplacental Perfusion in Pregnancy. Theranostics, 7 (15), 3715−3731.10.7150/thno.19678.
  • Scodeller, Pablo; Simón-Gracia, Lorena; Kopanchuk, Sergei; Tobi, Allan; Kilk, Kalle; Säälik, Pille; Kurm, Kaarel; Squadrito, Mario Leonardo; Kotamraju, Venkata Ramana; Rinken, Ago; De Palma, Michele; Ruoslahti, Erkki; Teesalu, Tambet (2017). Precision Targeting of Tumor Macrophages with a CD206 Binding Peptide. Scientific Reports, 7 (1), 14655−14655.10.1038/s41598-017-14709-x.
  • Mann, Aman P.; Scodeller, Pablo; Hussain, Sazid; Braun, Gary B.; Molder, Tarmo; Toome, Kadri; Ambasudhan, Rajesh; Teesalu, Tambet; Lipton, Stuart A.; Ruoslahti, Erkki (2017). Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer's disease. Nature Communications, 8, ARTN 1403.10.1038/s41467-017-01096-0.
  • Paasonen, L; Sharma, S; Braun, GB; Kotamraju, VR; Chung, TD; She, ZG; Sugahara, KN; Yliperttula, M; Wu, B; Pellecchia, M; Ruoslahti, E; Teesalu, T (2016). New p32/gC1qR Ligands for Targeted Tumor Drug Delivery. a european journal of chemical biology, 17 (7), 570−575.
  • Ewert, KK; Kotamraju, VR; Majzoub, RN; Steffes, VM; Wonder, EA; Teesalu, T; Ruoslahti, E; Safinya, CR (2016). Synthesis of linear and cyclic peptide-PEG-lipids for stabilization and targeting of cationic liposome-DNA complexes. Bioorganic & Medicinal Chemistry Letters, 26 (6), 1618−23.10.1016/j.bmcl.2016.01.079.
  • Braun, G B; Sugahara, K N; Yu, O M; Kotamraju, V,R; Mölder, T; Lowy, AM; Ruoslahti, E; Teesalu, T (2016). Urokinase-controlled tumor penetrating peptide. Journal of Controlled Release, 30240−30241.10.1016/j.jconrel.2016.04.027.
  • Simon-Gracia, Lorena; Hunt, Hedi; Scodeller, Pablo D; Gaitzsch, Jens; Braun, Gary B; Willmore, Anne-Mari A; Ruoslahti, Erkki; Battaglia, Giuseppe; Teesalu, Tambet (2016). Paclitaxel-Loaded Polymersomes for Enhanced Intraperitoneal Chemotherapy. Molecular cancer therapeutics, 15, 670−679.10.1158/1535-7163.MCT-15-0713-T.
  • King A, Ndifon C, Lui S, Widdows K, Kotamraju VR, Agemy L, Teesalu T, Glazier JD, Cellesi F, Tirelli N, Aplin JD, Ruoslahti E, Harris LK (2016). Tumor-homing peptides as tools for targeted delivery of payloads to the placenta. Science Advances, 2 (5), e1600349−0.10.1126/sciadv.1600349.
  • Mann AP, Scodeller P, Hussain S, Joo J, Kwon E, Braun GB, Mölder T, She ZG, Kotamraju VR, Ranscht B, Krajewski S, Teesalu T, Bhatia S, Sailor MJ, Ruoslahti E (2016). A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries. Nature Communications, 7, ARTN 11980.10.1038/ncomms11980.
  • Majzoub RN, Wonder E, Ewert KK, Kotamraju VR, Teesalu T, Safinya CR (2016). Rab11 and Lysotracker Markers Reveal Correlation between Endosomal Pathways and Transfection Efficiency of Surface-Functionalized Cationic Liposome-DNA Nanoparticles. The Journal of Physical Chemistry B, 120 (26), 6439−6453.10.1021/acs.jpcb.6b04441.
  • Willmore, AA.; Simón-Gracia, L.; Toome, K.; Paiste, P.; Kotamraju, VR.; Mölder, T.; Sugahara; KN.; Ruoslahti, E.; Braun, GB.; Teesalu, T. (2016). Targeted silver nanoparticles for ratiometric cell phenotyping. Nanoscale, 8 (17), 9096-101−9101.10.1039/c5nr07928d.
  • Simón-Gracia, Lorena; Hunt, Hedi; Scodeller, Pablo; Gaitzsch, Jens; Kotamraju, Ventaka R; Sugahara, Kazuki N; Tammik, Olav; Ruoslahti, Erkki; Battaglia, Giuseppe; Teesalu, Tambet (2016). iRGD peptide conjugation potentiates intraperitoneal tumor delivery of paclitaxel with polymersomes. Biomaterials, 104, 247−257.10.1016/j.biomaterials.2016.07.023.

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