Laboratory of Toxicology

 

Preclinical efficacy and safety testing of the new investigational drugs

 

Goal

Toxicology group acts as a preclinical contract research organization that provides in vitro and in vivo contract research services, as well as expert consulting services, supporting preclinical drug research and development. We offer a comprehensive package of research services for pharmaceutical industry and biotechnology companies in the preclinical efficacy and safety testing of drug candidates.

 

Research services

  • Testing of drug candidate on the variety of mouse/rat validated models of neurodegeneration, inflammation, pain, CNS disorders.
  • Human or animal primary neural cultures or cell lines to providing functional analysis of lead compounds in disease-relevant assays.
  • Toxicology testing, ranging from simple acute toxicity studies to complex general toxicity and toxicokinetic studies, prenatal  development  teratology, multi-generation reproduction studies as well as 24-month chronic carcinogenicity studies. Toxicology studies are good laboratory practice (GLP) compliant.
  • Highly-educated scientists provide advice for pharmaceutical product developers on the selection of test protocols, design of experiments, selection of appropriate test systems, data collection, statistical analysis and data interpretation.

 

People

  • Professor Aleksandr Žarkovski
  • Associate Professor Külli Jaako 
  • Research Fellow Monika Jürgenson 
  • Research Fellow Kaili Anier 
  • Research Fellow Mithu Guha
  • Research Fellow Janeli Viil
  • Research Fellow Tamara Žarkovskaja
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Doctoral defence: Marilin Ivask “Transcriptomic and metabolic changes in the WFS1-deficient mouse model”

On 29 Novembril at 15:00 Marilin Ivask will defend her doctoral thesis „Transcriptomic and metabolic changes in the WFS1-deficient mouse model“.
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Seminar by Prof Gregory Lavieu

Seminar by Professor Gregory Lavieu