Publications of the RNA Biology Research Group
2024
- Feng Y, Cai L, Pook M, Liu F, Chang CH, Mouti MA, Nibhani R, Militi S, Dunford J, Philpott M, Fan Y, Fan GC, Liu Q, Qi J, Wang C, Hong W, Morgan H, Wang M, Sadayappan S, Jegga AG, Oppermann U, Wang Y, Huang W, Jiang L, Pauklin S. BRD9-SMAD2/3 Orchestrates Stemness and Tumorigenesis in Pancreatic Ductal Adenocarcinoma. Gastroenterology. 2024 Jan;166(1):139-154.
- Kudrin P, Singh A, Meierhofer D, Kuśnierczyk A, Ørom UAV. N4-acetylcytidine (ac4C) promotes mRNA localization to stress granules. EMBO Rep. 2024 Feb 27.
- Kudrin P, Rebane A. Do RNA modifications contribute to modulation of immune responses in allergic diseases? Front Allergy. 2023 Nov 13;4:1277244.
- Periyasamy K, Maloverjan M, Biswas A, Remm A, Pook M, Rebane A, Pooga M. PepFect14 mediates the delivery of mRNA into human primary keratinocytes and in vivo. Front Pharmacol. 2023 Jul 13;14:1219761.
- Vaher H, Kingo K, Kolberg P, Pook M, Raam L, Laanesoo A, Remm A, Tenson T, Alasoo K, Mrowietz U, Weidinger S, Kingo K, Rebane A. Skin Colonization with S. aureus Can Lead to Increased NLRP1 Inflammasome Activation in Patients with Atopic Dermatitis. J Invest Dermatol. 2023 Jul;143(7):1268-1278.e8.
- Mouti MA, Deng S, Pook M, Malzahn J, Rendek A, Militi S, Nibhani R, Soonawalla Z, Oppermann U, Hwang CI, Pauklin S. KMT2A associates with PHF5A-PHF14-HMG20A-RAI1 subcomplex in pancreatic cancer stem cells and epigenetically regulates their characteristics. Nat Commun. 2023 Sep 14;14(1):5685.
- Vaher H, Kingo K, Kolberg P, Pook M, Raam L, Laanesoo A, Remm A, Tenson T, Alasoo K, Mrowietz U, Weidinger S, Kingo K, Rebane A. Skin Colonization with S. aureus Can Lead to Increased NLRP1 Inflammasome Activation in Patients with Atopic Dermatitis. J Invest Dermatol. 2023 Feb 1:S0022-202X(23)00066-0.
- Carreras-Badosa G, Maslovskaja J, Vaher H, Pajusaar L, Annilo T, Lättekivi F, Hübenthal M, Rodriguez E, Weidinger S, Kingo K, Rebane A. miRNA expression profiles of the perilesional skin of atopic dermatitis and psoriasis patients are highly similar. Sci Rep. 2022 Dec 31;12(1):22645.
- Meikar O, Majoral D, Heikkinen O, Valkama E, Leskinen S, Rebane A, Ruusuvuori P, Toppari J, Mäkelä JA, Kotaja N. STAGETOOL, a Novel Automated Approach for Mouse Testis Histological Analysis. Endocrinology. 2022 Dec 19;164(2)
- Jakiela B, Soja J, Sladek K, Przybyszowski M, Plutecka H, Gielicz A, Licholai S, Aab A, Rebane A, Bochenek G. Bronchial epithelial cell transcriptome shows endotype heterogeneity of asthma in patients with NSAID-exacerbated respiratory disease. J Allergy Clin Immunol. 2022 Nov 14:S0091-6749(22)01511-1.
- Chithanathan K, Jürgenson M, Guha M, Yan L, Žarkovskaja T, Pook M, Magilnick N, Boldin MP, Rebane A, Tian L, Zharkovsky A. Paradoxical attenuation of neuroinflammatory response upon LPS challenge in miR-146b deficient mice. Front Immunol. 2022 Oct 31;13:996415.
- Chithanathan K, Somelar K, Jürgenson M, Žarkovskaja T, Periyasamy K, Yan L, Magilnick N, Boldin MP, Rebane A, Tian L, Zharkovsky A. Enhanced Cognition and Neurogenesis in miR-146b Deficient Mice. Cells. 2022 Jun 22;11(13):2002.
- Maloverjan M, Padari K, Abroi A, Rebane A, Pooga M. Divalent Metal Ions Boost Effect of Nucleic Acids Delivered by Cell-Penetrating Peptides. Cells. 2022 Feb 21;11(4):756.
- Laanesoo A, Periyasamy K, Pooga M, Rebane A. Development of CPP-Based Methods for Delivery of miRNAs into the Skin and Airways: Lessons from Cell Culture and Mouse Models. Methods Mol Biol. 2022;2383:515-528.
- Laanesoo A, Urgard E, Periyasamy K, Laan M, Bochkov YA, Aab A, Magilnick N, Pooga M, Gern JE, Johnston SL, Coquet JM, Boldin MP, Wengel J, Altraja A, Bochenek G, Jakiela B, Rebane A. Dual role of the miR-146 family in rhinovirus-induced airway inflammation and allergic asthma exacerbation. Clin Transl Med. 2021 Jun;11(6):e427.
- Benito-Villalvilla C, Pérez-Diego M, Angelina A, Kisand K, Rebane A, Subiza JL, Palomares O. Allergoid-mannan conjugates reprogram monocytes into tolerogenic dendritic cells via epigenetic and metabolic rewiring. J Allergy Clin Immunol. 2021 Jun 18:S0091-6749(21)00968-4.
- Jakiela B, Rebane A, Soja J, Bazan-Socha S, Laanesoo A, Plutecka H, Surmiak M, Sanak M, Sladek K, Bochenek G. Remodeling of bronchial epithelium caused by asthmatic inflammation affects its response to rhinovirus infection. Sci Rep. 2021 Jun 17;11(1):12821.
- Weidner J, Bartel S, Kılıç A, Zissler UM, Renz H, Schwarze J, Schmidt-Weber CB, Maes T, Rebane A, Krauss-Etschmann S, Rådinger M. Spotlight on microRNAs in allergy and asthma. Allergy. 2021 Jun;76(6):1661-1678.
- Carreras-Badosa G, Maslovskaja J, Periyasamy K, Urgard E, Padari K, Vaher H, Tserel L, Gestin M, Kisand K, Arukuusk P, Lou C, Langel Ü, Wengel J, Pooga M, Rebane A. NickFect type of cell-penetrating peptides present enhanced efficiency for microRNA-146a delivery into dendritic cells and during skin inflammation. Biomaterials. 2020 Aug 29;262:120316.
- Jakiela B, Soja J, Sladek K, Przybyszowski M, Plutecka H, Gielicz A, Rebane A, Bochenek G. Heterogeneity of lower airway inflammation in patients with NSAID-exacerbated respiratory disease. J Allergy Clin Immunol. 2020 Aug 15:S0091-6749(20)31135-0.
- Vaher H, Kivihall A, Runnel T, Raam L, Prans E, Maslovskaja J, Abram K, Kaldvee B, Mrowietz U, Weidinger S, Kingo K, Rebane A. SERPINB2 and miR-146a/b are coordinately regulated and act in the suppression of psoriasis-associated inflammatory responses in keratinocytes. Exp Dermatol. 2020 Jan;29(1):51-60.
- Kivihall A, Aab A, Soja J, Sładek K, Sanak M, Altraja A, Jakiela B, Bochenek G, Rebane A. Reduced expression of miR-146a in human bronchial epithelial cells alters neutrophil migration. Clin Transl Allergy. 2019 Nov 27;9:62.
- Vaher H, Runnel T, Urgard E, Aab A, Carreras Badosa G, Maslovskaja J, Abram K, Raam L, Kaldvee B, Annilo T, Tkaczyk ER, Maimets T, Akdis CA, Kingo K, Rebane A. miR-10a-5p is increased in atopic dermatitis and has capacity to inhibit keratinocyte proliferation. Allergy. 2019 May 2. [Epub ahead of print]
- Venuti A, Musarra-Pizzo M, Pennisi R, Tankov S, Medici MA, Mastino A, Rebane A, Sciortino MT. HSV-1\EGFP stimulates miR-146a expression in a NF-κB-dependent manner in monocytic THP-1 cells. Sci Rep. 2019 Mar 26;9(1):5157.
- Raam L, Kaleviste E, Šunina M, Vaher H, Saare M, Prans E, Pihlap M, Abram K, Karelson M, Peterson P, Rebane A, Kisand K, Kingo K. Lymphoid Stress Surveillance Response Contributes to Vitiligo Pathogenesis. Front Immunol. 2018 Nov 20;9:2707.
- Carreras-Badosa G, Runnel T, Plaas M, Kärner J, Rückert B, Lättekivi F, Kõks S, Akdis CA, Kingo K, Rebane A. microRNA-146a is linked to the production of IgE in mice but not in atopic dermatitis patients. Allergy. 2018 Dec;73(12):2400-2403.
- Komlósi ZI, Kovács N, van de Veen W, Kirsch AI, Fahrner HB, Wawrzyniak M, Rebane A, Stanic B, Palomares O, Rückert B, Menz G, Akdis M, Losonczy G, Akdis CA. Human CD40 ligand-expressing type 3 innate lymphoid cells induce IL-10-producing immature transitional regulatory B cells. J Allergy Clin Immunol. 2018 Jul;142(1):178-194.
- Šahmatova L, Sügis E, Šunina M, Hermann H, Prans E, Pihlap M, Abram K, Rebane A, Peterson H, Peterson P, Kingo K, Kisand K.Signs of innate immune activation and premature immunosenescence in psoriasis patients. Sci Rep. 2017 Aug 8;7(1):7553.
- Urgard E, Brjalin A, Langel Ü, Pooga M, Rebane A, Annilo T. Comparison of Peptide- and Lipid-Based Delivery of miR-34a-5p Mimic into PPC-1 Cells. Nucleic Acid Ther. 2017 Oct;27(5):295-302.
- Hermann H, Runnel T, Aab A, Baurecht H, Rodriguez E, Magilnick N, Urgard E, Šahmatova L, Prans E, Maslovskaja J, Abram K, Karelson M, Kaldvee B, Reemann P, Haljasorg U, Rückert B, Wawrzyniak P, Weichenthal M, Mrowietz U, Franke A, Gieger C, Barker J, Trembath R, Tsoi LC, Elder JT, Tkaczyk ER, Kisand K, Peterson P, Kingo K, Boldin M, Weidinger S, Akdis CA, Rebane A. miR-146b Probably Assists miRNA-146a in the Suppression of Keratinocyte Proliferation and Inflammatory Responses in Psoriasis. J Invest Dermatol. 2017 Sep;137(9):1945-1954.
- Urgard E, Reigo A, Reinmaa E, Rebane A, Metspalu A (2017). Human basonuclin 2 up-regulates a cascade set of interferon-stimulated genes with anti-cancerous properties in a lung cancer model. Cancer Cell Int. 17: 18.
- Aab A, Wirz O, van de Veen W, Söllner S, Stanic B, Rückert B, Aniscenko J, Edwards MR, Johnston SL, Papadopoulos NG, Rebane A, Akdis CA, Akdis M (2017). Human rhinoviruses enter and induce proliferation of B lymphocytes. Allergy. 72: 232-243.
- Kärner J, Wawrzyniak M, Tankov S, Runnel T, Aints A, Kisand K, Altraja A, Kingo K, Akdis CA, Akdis M, Rebane A (2017). Increased microRNA-323-3p in IL-22/IL-17-producing T cells and asthma: a role in the regulation of the TGF-β pathway and IL-22 production. Allergy. 72: 55-65.
- Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA (2016). Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases. J Allergy Clin Immunol. 138: 984-1010.
- Duan S, Wanke K, Wawrzyniak P, Meng Y, Kast JI, Rückert B, Rebane A, Xian M, Bindslev-Jensen C, Broesby-Olsen S, Raap U, Werfel T, Akdis M, Zhang L, Akdis CA (2016). Platelet-activating factor decreases skin keratinocyte tight junction barrier integrity. J Allergy Clin Immunol. 138: 1725-1728.
- Urgard E, Lorents A, Klaas M, Padari K, Viil J, Runnel T, Langel K, Kingo K, Tkaczyk E, Langel Ü, Maimets T, Jaks V, Pooga M, Rebane A (2016). Pre-administration of PepFect6-microRNA-146a nanocomplexes inhibits inflammatory responses in keratinocytes and in a mouse model of irritant contact dermatitis. J Control Release. 235: 195-204.
- Šahmatova L, Tankov S, Prans E, Aab A, Hermann H, Reemann P, Pihlap M, Karelson M, Abram K, Kisand K, Kingo K, Rebane A (2016). MicroRNA-155 is Dysregulated in the Skin of Patients with Vitiligo and Inhibits Melanogenesis-associated Genes in Melanocytes and Keratinocytes. Acta Derm Venereol. 96: 742-747.
- Rebane A (2015). microRNA and Allergy. Adv Exp Med Biol. 888: 331-352.
- Maslovskaja J, Saare M, Liiv I, Rebane A, Peterson P (2015). Extended HSR/CARD domain mediates AIRE binding to DNA. Biochem Biophys Res Commun. 468: 913-920.
- Rebane A, Runnel T, Aab A, Maslovskaja J, Rückert B, Zimmermann M, Plaas M, Kärner J, Treis A, Pihlap M, Haljasorg U, Hermann H, Nagy N, Kemeny L, Erm T, Kingo K, Li M, Boldin MP, Akdis CA (2014). MicroRNA-146a alleviates chronic skin inflammation in atopic dermatitis through suppression of innate immune responses in keratinocytes. J Allergy Clin Immunol. 134: 836-847.
- Jartti T, Palomares O, Waris M, Tastan O, Nieminen R, Puhakka T, Rückert B, Aab A, Vuorinen T, Allander T, Vahlberg T, Ruuskanen O, Akdis M, Akdis CA (2014). Distinct regulation of tonsillar immune response in virus infection. Allergy. 69: 658-567.
- Jakiela B, Gielicz A, Plutecka H, Hubalewska-Mazgaj M, Mastalerz L, Bochenek G, Soja J, Januszek R, Aab A, Musial J, Akdis M, Akdis CA, Sanak M (2014). Th2-type cytokine induced mucous metaplasia decreases susceptibility of human bronchial epithelium to rhinovirus infection. Am J Respir Cell Mol Biol. 51: 229-241.
- Rebane A, Akdis CA (2014). MicroRNAs in allergy and asthma. Curr Allergy Asthma Rep. 14: 424.
- Rebane A, Akdis CA (2013). MicroRNAs: Essential players in the regulation of inflammation. J Allergy Clin Immunol. 132: 15-26.
- Kast JI, Wanke K, Soyka MB, Wawrzyniak P, Akdis D, Kingo K, Rebane A, Akdis CA (2012). The broad spectrum of interepithelial junctions in skin and lung. J Allergy Clin Immunol. 130: 544-547.
- Saare M, Rebane A, Rajashekar B, Vilo J, Peterson P (2012). Autoimmune regulator is acetylated by transcription coactivator CBP/p300. Exp Cell Res. 318: 1767-1778.
- Rebane A, Zimmermann M, Aab A, Baurecht H, Koreck A, Karelson M, Abram K, Metsalu T, Pihlap M, Meyer N, Fölster-Holst R, Nagy N, Kemeny L, Kingo K, Vilo J, Illig T, Akdis M, Franke A, Novak N, Weidinger S, Akdis CA (2012). Mechanisms of IFN-γ-induced apoptosis of human skin keratinocytes in patients with atopic dermatitis. J Allergy Clin Immunol. 129: 1297-1306.
- Tserel L, Runnel T, Kisand K, Pihlap M, Bakhoff L, Kolde R, Peterson H, Vilo J, Peterson P, Rebane A (2011). MicroRNA expression profiles of human blood monocyte-derived dendritic cells and macrophages reveal miR-511 as putative positive regulator of Toll-like receptor 4. J Biol Chem. 286: 26487-26495.