Research of the Department of Pathophysiology

Our current focus

To describe novel pathways emerging from pathogenetic changes in energy metabolism and endoplamic reticulum stress.
To discover genetic networks and molecular mechanisms related to pathogenesis of bone- and muscle diseases, including opsteoporosis, ostheoarthritis and sarcopenia and in development of heart failure.
To characterize proteomic specificity of Wfs-1 deficient mice muscles in parallel with transcriptional and pathophysiological changes.

Grants

Particle Metrics GbmH: Staining study to – differentiate organelle originated EV´s from other nanoparticles – via f-NTA (Particle Metrix QUATT) Part II (Professor Alireza Fazeli, VMVBS23442, 01.09.2023–31.08.2024)

Integrated model for personalized diabetic retinopathy screening and monitoring using risk-stratification and automated AI-based fundus image analysis – PerDiRe

EEA-RESEARCH-60 Funded by EEA Grants
Implementation period 01.05.2021–30.04.2024

Funding 1 000 000 Euros

The aim of the project is to implement a new personalized diabetic retinopathy screening and monitoring program using artificial intelligence (AI) for future applications in the care of patients with diabetes.

Partners
Project is led by University of Latvia (Dr Jelizaveta Sokolovska)
Lithuanian University of Health Sciences Prof. Rasa Verkauskienė
University of Oslo Prof. Goran Petrovski
University of Tartu Prof. Vallo Volke

Work Packages

Financier

Current collaborations

In Estonia: National Institute of Chemical Physics and Biophysics; Traumathology and Orthopaedics Clinic of University of Tartu.
International: Hue University of Medicine and Pharmacy (Vietnam)

Biobanks

samples of various human sceletal muscles, collected for sarcopenia studies within MYOAGE Project. Collected in collaboration with Traumathology and Orthopaedics Clinic, University of Tartu.
Biological samples from 110 osteosarcoma patients.

Databaseses

The mass spectrometry proteomics data of wolframin-deficient mouse heart and skeletal muscles, deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifierPXD011019 https://www.ebi.ac.uk/pride/archive/projects/PXD011019

The five most important publications in the last five years

Pääsuke, Reedik; Eimre, Margus; Piirsoo, Andres; Peet, Nadežda; Laada, Liidia; Kadaja, Lumme; Roosimaa, Mart; Pääsuke, Mati; Märtson, Aare; Seppet, Enn; Paju, Kalju (2016). Proliferation of human primary myoblasts is associated with altered energy metabolism in dependence of ageing in vivo and in vitro. Oxidative Medicine and Cellular Longevity, Article ID 8296150, 10 pages−x.10.1155/2016/8296150.
Ivask, Marilin; Pajusalu, Sander; Reimann, Ene; Kõks, Sulev (2018). Hippocampus and Hypothalamus RNA-sequencing of WFS1-deficient Mice. Neuroscience, 374, 91−103.10.1016/j.neuroscience.2018.01.039.
Lattekivi, Freddy; Koks, Sulev; Keermann, Maris; Reimann, Ene; Prans, Ele; Abram, Kristi; Silm, Helgi; Koks, Gea; Kingo, Kulli (2018). Transcriptional landscape of human endogenous retroviruses (HERVs) and other repetitive elements in psoriatic skin. Scientific Reports, 8, ARTN 4358.10.1038/s41598-018-22734-7.
Eimre, Margus; Paju, Kalju; Peet, Nadežda; Kadaja, Lumme; Tarrend, Marian; Kasvandik, Sergo; Seppet, Joosep; Ivask, Marilin; Orlova, Ehte; Kõks, Sulev (2018). Increased Mitochondrial Protein Levels and Bioenergetics in the Musculus Rectus Femoris of Wfs1-Deficient Mice. Oxidative Medicine and Cellular Longevity, 1−12.10.1155/2018/3175313.
Eimre, Margus; Kasvandik, Sergo; Ivask, Marilin; Kõks, Sulev (2018). Proteomic dataset of wolframin-deficient mouse heart and skeletal muscles. Data in Brief, 21, 616−619.10.1016/j.dib.2018.10.015.