Research of the Institute of Biomedicine and Translational Medicine

The Institute of Biomedicine and Translational Medicine at the University of Tartu is a research and education institute in biomedical sciences. The research areas include basic and translational medicine.The mission is to create an internationally high standard research and education institute operating in the field of biomedicine.

The specific research projects are given at homepages of each work group:

Read more about of the Department of Pharmacology.

 

Project: Unraveling the molecular mechanisms underlying Ca2+-signaling modulation by CISD2, a wolfram syndrome-associated gene, and its interplay with Bcl-2 (Flemish Research Council, MMVBS21348)
Period: 01.01.2021−31.12.2024
Contact: Professor Allen Kaasik
E-mail: allen.kaasik@ut.ee

Project: Exploration of the therapeutic potential of the active vitamin D analogues: focus on the mood disorders and obesity (Estonian Research Council, GMVBS20080PR)
Period: 01.01.2010−31.12.2024
Contact: Professor Aleksandr Žarkovski
E-mail: aleksandr.zarkovski@ut.ee

Project: The effect of DNA methyltransferase-inhibitor treatment on aberrant DNA methylation in human leukocytes: A novel pharmacological strategy for treatment of psychostimulant-induced drug addiction (Estonian Research Council, GMVBS22063PR)
Period: 01.01.2022−31.12.2026
Contact: Professor Anti Kalda
E-mail: anti.kalda@ut.ee

Project: Targeting the endoplasmic reticulum-mitochondrial interface as a therapeutic strategy for neurodegenerative diseases (Estonian Research Council, GMVBS24041PR)
Period: 01.01.2024−31.12.2028
Contact: Professor Allen Kaasik
E-mail: allen.kaasik@ut.ee

Read more about of the Department of Physiology.

 

Project: Potential biomarkers for the diagnosis, prognosis, and evaluation of treatment impact for first episode psychosis and schizophrenia spectrum disorders: translational approach (Estonian Research Council, GMVBS20067PR)
Period: 01.01.2020−31.12.2024
Contact: Professor Eero Vasar
E-mail: eero.vasar@ut.ee

Project: Endocannabinoid system as a possible modulator of psychiatric effects of the adhesion molecule Negr1 (Estonian Research Council, SMVBS22511)
Period: 01.12.2022−30.11.2024
Contact: Associate Professor Este Leidmaa
E-mail: este.leidmaa@ut.ee

Project: HIF1B as a Novel Hypothermia Response Factor with Therapeutic Benefits (Estonian Research Council, GMVBS24069PS)
Period: 01.01.2024-31.12.2028
Contact: Research Fellow Kattri-Liis Eskla
E-mail: kattri-liis.eskla@ut.ee

The research projects of the Department of Biomedicine 

Read more about the research of the Molecular Pathology Research Group.

 

Project: Type I interferons and their autoantibodies in autoimmunity and COVID-19 (Estonian Research Council, GMVBS21081PR) 
Period: 01.01.2021−31.12.2025
Contact: Professor Kai Kisand
E-mail: kai.kisand@ut.ee

Project: European Network Linking Informatics and Genomics of Helper T cells in Tissues (European Commission Horizon2020, MSCA Enlighten+, MMVBS21006R)
Period: 01.03.2021−28.02.2025
Contact: Professor Pärt Peterson 
E-mail: part.peterson@ut.ee

Project: Molecular mechanisms underlying impaired antiviral cytotoxic T cell responses in old age (Estonian Research Council, SMVBS21533)
Period: 01.12.2021−31.12.2025
Contact: Research Fellow Maarja Laos 
E-mail: maarja.laos@ut.ee

Project: The human genetic and immunological determinants of the clinical manifestations of SARS-CoV-2 infection: Towards personalised medicine (European Commission, MMVBS22163R)
Period: 01.06.2022−31.05.2026
Contact: Professor Kai Kisand
E-mail: kai.kisand@ut.ee

Project: Age-Related Changes in T Cells (Estonian Research Council, GMVBS24044PR)
Period: 01.01.2024−31.12.2028
Contact: Professor Pärt Peterson  
E-mail: part.peterson@ut.ee

Project: Preventing non-communicable diseases caused by the post-acute phase of cOvid-19 INfecTion (European Commission Horizon2020, GMVBS24044PR)
Period: 01.01.2024−31.12.2027
Contact: Professor Pärt Peterson  
E-mail: part.peterson@ut.ee

Project: Enterovirus-linked type1 diabetes exposed - mechanisms and preventions (European Commission Horizon2020, MMVBS24075R)
Period: 01.01.2024−31.12.2027
Contact: Professor Pärt Peterson  
E-mail: part.peterson@ut.ee

Read more about the research of the Laboratory of Precision and Nanomedicine.

 

Project: LDL-like nanoparticles for CAR-T-based glioblastoma immunotherapy (Estonian Research Council, SMVBS21620)
Period: 13.12.2021−12.12.2024
Contact: Professor Tambet Teesalu
E-mail: tambet.teesalu@ut.ee

Project: Peptide-targeted nanoparticles for delivery of therapeutics to tuberculosis (Bill and Melinda Gates Foundation, MMVBS21410)
Period: 07.04.2021−30.04.2025
Contact: Professor Tambet Teesalu
E-mail: tambet.teesalu@ut.ee

Project: Hemoglobin based Protein Nanocarriers for Tumour Oxygenation and a more effective Photodynamic Therapy (European Commission, MMVBS18435R)
Period: 01.03.2019−31.08.2024 
Contact: Professor Tambet Teesalu
E-mail: tambet.teesalu@ut.ee

Project: Precision targeting of infiltrative glioblastoma (Estonian Research Council, GMVBS23048PR)
Period: 01.01.2023−31.12.2027
Contact: Professor Tambet Teesalu
E-mail: tambet.teesalu@ut.ee

Project: Macrophage-targeting Nanoplatforms as Immunotherapy against Pulmonary Infections (USA, MMVBS24156)
Period: 11.01.2024−30.11.2024
Contact: Professor Tambet Teesalu
E-mail: tambet.teesalu@ut.ee

Read more about the research of the RNA Biology Research Group.

 

Project: Adjustment of tissue-specific immune responses in chronic inflammatory diseases by miRNAs (Estonian Research Council, GMVBS21063PR)
Period: 01.01.2021−31.12.2025
Contact: Professor Ana Rebane  
E-mail: ana.rebane@ut.ee

Project: Biomarkers in Atopic Dermatitis and Psoriasis (European Commission, Horizon2020, MMVBS19122)
Period: 01.01.2023−31.12.2025
Contact: Professor Ana Rebane  
E-mail: ana.rebane@ut.ee

Project: Precision targeting of infiltrative glioblastoma (Estonian Research Council, SMVBS22358)
Period: 01.09.2022−31.08.2024
Contact: Research Fellow Pavel Kudrin
E-mail: pavel.kudrin@ut.ee

Read more about the research of the Chair of Human Genetics.

 

Project: Mono- and digenic causes of male infertility in the exome sequencing era: novel genes, digenic inheritance, pleiotropic effects and clinical implications (Estonian Research Council, GMVBS21064PR)
Period: 01.01.202131.12.2025
Contact: Professor Maris Laan 
E-mail: maris.laan@ut.ee

Read more about the research of the Department of Immunology.

 

Project: Immune mechanisms in adulthood diabetes (Estonian Research Council, GMVBS0377PR)
Period: 01.01.2020–31.12.2024
Contact: Professor Raivo Uibo  
E-mail: raivo.uibo@ut.ee

Project: Human Exposomic Determinants of Immune Mediated Diseases (European Commission Horizon2020, MMVBS20017R)
Period: 01.01.2020–31.12.2024
Contact: professor Raivo Uibo  
E-mail: raivo.uibo@ut.ee

Read more about the research of the Department of Pathophysiology.

 

Project: Integrated model for personalized diabetic retinopathy screening and monitoring using risk-stratification and automated AI-based fundus image analysis (State Education Development Agency (SEDA), MMVBS21381)
Period: 01.05.2021–30.04.2024 
Contact: professor Vallo Volke  
E-mail: vallo.volke@ut.ee

Project: Staining study to – differentiate organelle originated EV´s from other nanoparticles – via f-NTA (Particle Metrix QUATT) Part II (Particle Metrics GbmH, VMVBS23442)
Period: 01.09.2023–31.08.2024 
Contact: Professor Alireza Fazeli
E-mail: alireza.fazeli@ut.ee

Read more about the research of the Department of Anatomy.

 

Project: Human histology (Institute of the Estonian Language, DMVBS21510)
Period: 16.09.2021–01.09.2024
Contact: Associate Professor Marina Aunapuu
E-mail: marina.aunapuu@ut.ee

Read more about the research of the Department of Microbiology.

 

Project: conect4children- COllaborative Network for European Clinical Trials For Children (European Commission Horizon2020, MMVBS18106R)
Period: 01.05.2018–30.04.2024
Contact: Professor Irja Lutsar
E-mail: irja.lutsar@ut.ee

Project: Delivering a Unified Research Alliance of Biomedical and public health Laboratories against Epidemics (European Commission, MMVBS23022)
Period: 01.02.2023–31.01.2027
Contact: Professor Irja Lutsar
E-mail: irja.lutsar@ut.ee

Project: Boosting the One Health Research Excellence and Management Capacity of the Estonian University of Life Sciences (European Commission, MMVBS23128R)
Period: 01.01-2023–31.12.2025
Contact: Professor Irja Lutsar
E-mail: irja.lutsar@ut.ee

Project: SARS-coV2 variants Evaluation in pRegnancy and paeDIatrics cohorts (European Commission, MMVBS23269R)
Period: 01.05.2023–31.10.2025
Contact: Professor Irja Lutsar
E-mail: irja.lutsar@ut.ee

 

 

Project: GLP1 receptor agonist Liraglutide and NRF2 activator RTA-408 therapy to relieve neurodegenerative symptoms in rat model of Wolfram syndrome (Estonian Research Council, GMVBS20066PS)
Period: 01.01.2020–31.12.2023 
Contact: Associate Professor Mario Plaas
E-mail: mario.plaas@ut.ee

Project: Postnatal dysregulation of interneuron development in Wolfram Syndrome: A novel symptom and therapeutic target? (Estonian Research Council, SMVBS22510)
Period: 01.12.2022–30.11.2024 
Contact: Associate Professor Mario Plaas
E-mail: mario.plaas@ut.ee

Project: The Role of RNA-recognition Motif of NELFE in Brain Physiology (Estonian Research Council, GMVBS23135J)
Period: 01.03.2023–28.05.2025
Contact: Research Fellow Kadri Seppa
E-mail: kadri.seppa@ut.ee

Project: In vivo safety tests for probiotics (BioCC OÜ, LMVBS22224)
Period: 08.04.2022–31.12.2023
Contact: Associate Professor Mario Plaas
E-mail: mario.plaas@ut.ee

Project: Loss of Wfs1 affects the development and function of GABAergic pathways (TSF) (The Snow Foundation (TSF), MMVBS22562)
Period: 01.07.2022–31.12.2023
Contact: Associate Professor Mario Plaas
E-mail: mario.plaas@ut.ee

Tartu Ülikool uuring näitas, et ühest geeniveast põhjustatud mehepoolne viljatus on arvatust palju sagedasem.

One of the largest male infertility genetic studies improves molecular diagnostics and personalized management of andrology patients

Koroonaviirus

European Commission funds research to tackle long-term COVID-19 health impact

Doctoral defence: Fangling Xuan „Regulation of stress response in first episode schizophrenia by monocytes and microglia“

17. mail kaitseb Fangling Xuan doktoritööd „Regulation of stress response in first episode schizophrenia by monocytes and microglia” (,,Stressivastuse reguleerimine skisofreenia esimese episoodi korral monotsüütide ja mikrogliia poolt“).