Molekulaarpatoloogia uurimisrühma publikatsioonid

 

2021

  • Kallaste A, Kisand K, Aart A, Kisand K, Peterson P, Lember M. Antibody levels remain high to one-year's follow-up after moderate and severe COVID-19, but not after mild cases. Infect Dis (Lond). 2021 Dec 24:1-11. doi: 10.1080/23744235.2021.2018492. Epub ahead of print. PMID: 34951554.
  • Erdős M, Kärner J, Ranki A, Kisand K, Maródi L. Persistently Increased Anti- cytokine Antibodies Without Clinical Disease in a Boy with APS1 Genotype. J Clin Immunol. 2021 Dec 23:1–4. doi: 10.1007/s10875-021-01164-7. Epub ahead of print. PMID: 34940925; PMCID: PMC8696966.
  • Hetemäki I, Kaustio M, Kinnunen M, Heikkilä N, Keskitalo S, Nowlan K, Miettinen S, Sarkkinen J, Glumoff V, Andersson N, Kettunen K, Vanhanen R, Nurmi K, Eklund KK, Dunkel J, Mäyränpää MI, Schlums H, Arstila TP, Kisand K, Bryceson YT, Peterson P, Otava U, Syrjänen J, Saarela J, Varjosalo M, Kekäläinen E. Loss- of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells. Sci Immunol. 2021 Nov 26;6(65):eabe3454. doi: 10.1126/sciimmunol.abe3454. Epub 2021 Nov 26. PMID: 34826260.
  • Tserel L, Jõgi P, Naaber P, Maslovskaja J, Häling A, Salumets A, Zusinaite E, Soeorg H, Lättekivi F, Ingerainen D, Soots M, Toompere K, Kaarna K, Kisand K, Lutsar I, Peterson P. Long-Term Elevated Inflammatory Protein Levels in Asymptomatic SARS-CoV-2 Infected Individuals. Front Immunol. 2021 Sep 17;12:709759. doi: 10.3389/fimmu.2021.709759. PMID: 34603283; PMCID: PMC8484961.
  • Peterson P, Kisand K, Kluger N, Ranki A. Loss of AIRE-Mediated Immune Tolerance and the Skin. J Invest Dermatol. 2021 Sep 14:S0022-202X(21)01241-0. doi: 10.1016/j.jid.2021.04.022. Epub ahead of print. PMID: 34535292.
  • Kisand K, Meager A, Hayday A, Willcox N. Comment on "Aberrant type 1 immunity drives susceptibility to mucosal fungal infections". Science. 2021 Sep 17;373(6561):eabi6235. doi: 10.1126/science.abi6235. Epub 2021 Sep 16. PMID: 34529474.
  • Naaber P, Tserel L, Kangro K, Sepp E, Jürjenson V, Adamson A, Haljasmägi L, Rumm AP, Maruste R, Kärner J, Gerhold JM, Planken A, Ustav M, Kisand K, Peterson P. Dynamics of antibody response to BNT162b2 vaccine after six months: a longitudinal prospective study. Lancet Reg Health Eur. 2021 Nov;10:100208. doi: 10.1016/j.lanepe.2021.100208. Epub 2021 Sep 6. PMID: 34514454; PMCID: PMC8418937.
  • Asano T, Boisson B, Onodi F, Matuozzo D, Moncada-Velez M, Maglorius Renkilaraj MRL, Zhang P, Meertens L, Bolze A, Materna M, Korniotis S, Gervais A, Talouarn E, Bigio B, Seeleuthner Y, Bilguvar K, Zhang Y, Neehus AL, Ogishi M, Pelham SJ, Le Voyer T, Rosain J, Philippot Q, Soler-Palacín P, Colobran R, Martin-Nalda A, Rivière JG, Tandjaoui-Lambiotte Y, Chaïbi K, Shahrooei M, Darazam IA, Olyaei NA, Mansouri D, Hatipoğlu N, Palabiyik F, Ozcelik T, Novelli G, Novelli A, Casari G, Aiuti A, Carrera P, Bondesan S, Barzaghi F, Rovere- Querini P, Tresoldi C, Franco JL, Rojas J, Reyes LF, Bustos IG, Arias AA, Morelle G, Christèle K, Troya J, Planas-Serra L, Schlüter A, Gut M, Pujol A, Allende LM, Rodriguez-Gallego C, Flores C, Cabrera-Marante O, Pleguezuelo DE, de Diego RP, Keles S, Aytekin G, Akcan OM, Bryceson YT, Bergman P, Brodin P, Smole D, Smith CIE, Norlin AC, Campbell TM, Covill LE, Hammarström L, Pan-Hammarström Q, Abolhassani H, Mane S, Marr N, Ata M, Al Ali F, Khan T, Spaan AN, Dalgard CL, Bonfanti P, Biondi A, Tubiana S, Burdet C, Nussbaum R, Kahn-Kirby A, Snow AL; COVID Human Genetic Effort; COVID-STORM Clinicians; COVID Clinicians; Imagine COVID Group; French COVID Cohort Study Group; CoV-Contact Cohort; Amsterdam UMC Covid-; Biobank; NIAID-USUHS COVID Study Group, Bustamante J, Puel A, Boisson- Dupuis S, Zhang SY, Béziat V, Lifton RP, Bastard P, Notarangelo LD, Abel L, Su HC, Jouanguy E, Amara A, Soumelis V, Cobat A, Zhang Q, Casanova JL. X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19. Sci Immunol. 2021 Aug 19;6(62):eabl4348. doi: 10.1126/sciimmunol.abl4348. PMID: 34413140; PMCID: PMC8532080.
  • Bastard P, Gervais A, Le Voyer T, Rosain J, Philippot Q, Manry J, Michailidis E, Hoffmann HH, Eto S, Garcia-Prat M, Bizien L, Parra-Martínez A, Yang R, Haljasmägi L, Migaud M, Särekannu K, Maslovskaja J, de Prost N, Tandjaoui- Lambiotte Y, Luyt CE, Amador-Borrero B, Gaudet A, Poissy J, Morel P, Richard P, Cognasse F, Troya J, Trouillet-Assant S, Belot A, Saker K, Garçon P, Rivière JG, Lagier JC, Gentile S, Rosen LB, Shaw E, Morio T, Tanaka J, Dalmau D, Tharaux PL, Sene D, Stepanian A, Megarbane B, Triantafyllia V, Fekkar A, Heath JR, Franco JL, Anaya JM, Solé-Violán J, Imberti L, Biondi A, Bonfanti P, Castagnoli R, Delmonte OM, Zhang Y, Snow AL, Holland SM, Biggs C, Moncada-Vélez M, Arias AA, Lorenzo L, Boucherit S, Coulibaly B, Anglicheau D, Planas AM, Haerynck F, Duvlis S, Nussbaum RL, Ozcelik T, Keles S, Bousfiha AA, El Bakkouri J, Ramirez-Santana C, Paul S, Pan-Hammarström Q, Hammarström L, Dupont A, Kurolap A, Metz CN, Aiuti A, Casari G, Lampasona V, Ciceri F, Barreiros LA, Dominguez-Garrido E, Vidigal M, Zatz M, van de Beek D, Sahanic S, Tancevski I, Stepanovskyy Y, Boyarchuk O, Nukui Y, Tsumura M, Vidaur L, Tangye SG, Burrel S, Duffy D, Quintana-Murci L, Klocperk A, Kann NY, Shcherbina A, Lau YL, Leung D, Coulongeat M, Marlet J, Koning R, Reyes LF, Chauvineau-Grenier A, Venet F, Monneret G, Nussenzweig MC, Arrestier R, Boudhabhay I, Baris-Feldman H, Hagin D, Wauters J, Meyts I, Dyer AH, Kennelly SP, Bourke NM, Halwani R, Sharif-Askari NS, Dorgham K, Sallette J, Sedkaoui SM, AlKhater S, Rigo-Bonnin R, Morandeira F, Roussel L, Vinh DC, Ostrowski SR, Condino-Neto A, Prando C, Bonradenko A, Spaan AN, Gilardin L, Fellay J, Lyonnet S, Bilguvar K, Lifton RP, Mane S; HGID Lab; COVID Clinicians; COVID-STORM Clinicians; NIAID Immune Response to COVID Group; NH-COVAIR Study Group; Danish CHGE; Danish Blood Donor Study; St. James's Hospital; SARS CoV2 Interest group; French COVID Cohort Study Group; Imagine COVID-Group; Milieu Intérieur Consortium; CoV-Contact Cohort; Amsterdam UMC Covid-19; Biobank Investigators; COVID Human Genetic Effort; CONSTANCES cohort; 3C-Dijon Study; Cerba Health-Care; Etablissement du Sang study group, Anderson MS, Boisson B, Béziat V, Zhang SY, Vandreakos E, Hermine O, Pujol A, Peterson P, Mogensen TH, Rowen L, Mond J, Debette S, de Lamballerie X, Duval X, Mentré F, Zins M, Soler- Palacin P, Colobran R, Gorochov G, Solanich X, Susen S, Martinez-Picado J, Raoult D, Vasse M, Gregersen PK, Piemonti L, Rodríguez-Gallego C, Notarangelo LD, Su HC, Kisand K, Okada S, Puel A, Jouanguy E, Rice CM, Tiberghien P, Zhang Q, Cobat A, Abel L, Casanova JL. Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths. Sci Immunol. 2021 Aug 19;6(62):eabl4340. doi: 10.1126/sciimmunol.abl4340. PMID: 34413139; PMCID: PMC8521484.
  • Jõgi P, Soeorg H, Ingerainen D, Soots M, Lättekivi F, Naaber P, Toompere K, Peterson P, Haljasmägi L, Žusinaite E, Vaas H, Pauskar M, Shablinskaja A, Kaarna K, Paluste H, Kisand K, Oona M, Janno R, Lutsar I. Prevalence of SARS-CoV-2 IgG antibodies and their association with clinical symptoms of COVID-19 in Estonia (KoroSero-EST-1 study). Vaccine. 2021 Sep 7;39(38):5376-5384. doi: 10.1016/j.vaccine.2021.07.093. Epub 2021 Aug 5. PMID: 34393019; PMCID: PMC8339569.
  • COVID-19 Host Genetics Initiative. Mapping the human genetic architecture of COVID-19. Nature. 2021 Dec;600(7889):472-477. doi: 10.1038/s41586-021-03767-x. Epub 2021 Jul 8. PMID: 34237774; PMCID: PMC8674144.
  • Benito-Villalvilla C, Pérez-Diego M, Angelina A, Kisand K, Rebane A, Subiza JL, Palomares O. Allergoid-mannan conjugates reprogram monocytes into tolerogenic dendritic cells via epigenetic and metabolic rewiring. J Allergy Clin Immunol. 2022 Jan;149(1):212-222.e9. doi: 10.1016/j.jaci.2021.06.012. Epub 2021 Jun 18. PMID: 34153371.
  • Bondet V, Rodero MP, Posseme C, Bost P, Decalf J, Haljasmägi L, Bekaddour N, Rice GI, Upasani V, Herbeuval JP, Reynolds JA, Briggs TA, Bruce IN, Mauri C, Isenberg D, Menon M, Hunt D, Schwikowski B, Mariette X, Pol S, Rozenberg F, Cantaert T, Eric Gottenberg J, Kisand K, Duffy D. Differential levels of IFNα subtypes in autoimmunity and viral infection. Cytokine. 2021 Aug;144:155533. doi: 10.1016/j.cyto.2021.155533. Epub 2021 Apr 30. PMID: 33941444.
  • Bastard P, Orlova E, Sozaeva L, Lévy R, James A, Schmitt MM, Ochoa S, Kareva M, Rodina Y, Gervais A, Le Voyer T, Rosain J, Philippot Q, Neehus AL, Shaw E, Migaud M, Bizien L, Ekwall O, Berg S, Beccuti G, Ghizzoni L, Thiriez G, Pavot A, Goujard C, Frémond ML, Carter E, Rothenbuhler A, Linglart A, Mignot B, Comte A, Cheikh N, Hermine O, Breivik L, Husebye ES, Humbert S, Rohrlich P, Coaquette A, Vuoto F, Faure K, Mahlaoui N, Kotnik P, Battelino T, Trebušak Podkrajšek K, Kisand K, Ferré EMN, DiMaggio T, Rosen LB, Burbelo PD, McIntyre M, Kann NY, Shcherbina A, Pavlova M, Kolodkina A, Holland SM, Zhang SY, Crow YJ, Notarangelo LD, Su HC, Abel L, Anderson MS, Jouanguy E, Neven B, Puel A, Casanova JL, Lionakis MS. Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1. J Exp Med. 2021 Jul 5;218(7):e20210554. doi: 10.1084/jem.20210554. PMID: 33890986; PMCID: PMC8077172.
  •  Laan M, Salumets A, Klein A, Reintamm K, Bichele R, Peterson H, Peterson P. Post-Aire Medullary Thymic Epithelial Cells and Hassall's Corpuscles as Inducers of Tonic Pro Inflammatory Microenvironment. Front Immunol. 2021 Apr 2;12:635569. doi: 10.3389/fimmu.2021.635569. PMID: 33868260; PMCID: PMC8050345.
  • Duguet F, Ortega-Ferreira C, Fould B, Darville H, Berger S, Chomel A, Leclerc G, Kisand K, Haljasmägi L, Hayday AC, Desvaux E, Nony E, Moingeon P, De Ceuninck F. S95021, a novel selective and pan-neutralizing anti interferon alpha (IFN-α) monoclonal antibody as a candidate treatment for selected autoimmune rheumatic diseases. J Transl Autoimmun. 2021 Mar 1;4:100093. doi: 10.1016/j.jtauto.2021.100093. PMID: 33748735; PMCID: PMC7972961.
  • Patentne leiutis: Human anti-IL-32 antibodies; Omanikud: Immunoqure AG; Autorid: Adrian Hayday, Kai Krohn, Annalisa Macagno, Shimobi Onuoha, Pärt Peterson, Mike Rothe, Martin Woodward, Syeda Haque, Kai Kisand; Prioriteedi number: EP20130174937 20130703; Prioriteedi kuupäev: 3.07.2013.
  • Patentne leiutis: Human anti-IFN-alpha antibodies; Omanikud: Immunoqure AG; Autorid: Syeda Haque, Adrian Hayday, Kai Krohn, Annalisa Macagno, Steffen Meyer, Pärt Peterson, Mike Rothe, Philip Vlaicu, Martin Woodward, Kai Kisand; Prioriteedi number: EP20130174995 20130703; Prioriteedi kuupäev: 3.07.2013.
  • Patentne leiutis: Method of providing monoclonal auto-antibodies with desired specificity; Omanikud: Immunoqure AG; Autorid: Adrian Hayday, Annamari Päivi Ranki, Pärt Peterson, Edward Stuart, Annalisa Macagno, Shimobi Onuoha, Kai Kisand; Prioriteedi number: US201314369467 20130102; Prioriteedi kuupäev: 28.12.2011.
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D-vitamiin. Tartu Ülikool

Katsed hiirtega näitasid, et D-vitamiini puudus halvendab mälu

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Eduard Jonas "Managment of pancreatic and bile duct trauma"

Teisipäeval 22.11 kell 8.15-9.00 toimub A. Linkbergi nimelises auditooriumis L. Puusepa 8  välisprofessori loeng.
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Marilin Ivask kaitseb doktoritööd „Transcriptomic and metabolic changes in the WFS1-deficient mouse model“

29. novembril kell 15 kaitseb Marilin Ivask doktoritööd „Transcriptomic and metabolic changes in the WFS1-deficient mouse model“.