Towards better understanding of brittle bone disease
A doctoral thesis written at the University of Tartu studied a rare genetic disorder of the connective tissue, Osteogenesis imperfecta, more commonly known as brittle bone disease. It affects 1 in 20,000 people. In about 90% of cases, the main target of the disease is type I collagen, which is the base structure of bone, tendons, cartilage and other connective tissues. The results of the doctoral thesis help improve diagnosing and further studying of the disease.