Research of the Chair of Pathological Anatomy

Our current focus

The key words of pathology research group led by Ave Minajeva are digital pathology, whole slide imaging (WSI), machine learning (ML), neoplastic stromal biomarkers.
Basic and translational research in last 5 years comprises WSI and ML digital analysis and software development. A team led by Georgi Džaparidze has developed an open code program Pathadin. The source code, slicing, and training pipelines, as well as trained models and instructions to help anyone willing to contribute to computer-assisted diagnostics are provided at the open repository. 

Pathadin - open-source tool for WSI-oriented analysis and creating machine learning applications.

Main grants

In recent years as a reasearcher in study of brain tumors (Ave Minajeva) in the grant IUT2-4 Novel diagnostic markers of nervous system diseases and factors predicting treatment outcome (Toomas Asser, University of Tartu, Institute of Clinical Medicine).

Current collaborations

Department of Pathological aAnatomy is introducing digital pathology in Estonia both in clinical diagnostics and in education.

In Estonia – East Tallinn Central Hospital, West Tallinn Central Hospital, Tartu University Hospital, Estonian Forensic Science Institute
Internationally – Riga Stradiņš University

Most important scientific articles in last five years

1. Minajeva, Ave; Saranova, Diana (2022). Mesothelioma: Overview of Technical, Immunochemical and Pathomorphological Diagnosing Aspects. In: Ilze Strumfa (Ed.). Mesothelioma - Diagnostics, Treatment and Basic Research. London: IntechOpen. DOI: 10.5772/intechopen.106570.
2. Dzaparidze, Georgi; Anion, Evelin; Laan, Maris; Minajeva, Ave. (2020). The decline of FANCM immunohistochemical expression in prostate cancer stroma correlates with the grade group. Pathology International, 70 (8), 542−550. DOI: 10.1111/pin.12953.  
3. Dzaparidze, Georgi; Kazachonok, Dmitri; Laht, Kristi; Taelma, Heleri; Minajeva, Ave (2020). Pathadin – The essential set of tools to start with whole slide analysis. Acta Histochemica, 122 (7), 151619. DOI: 10.1016/j.acthis.2020.151619. 
4. Dzaparidze, Georgi; Kazachonok, Dmitri; Gvozdkov, Alexander; Taelma, Heleri; Laht, Kristi; Minajeva, Ave (2021). Diagnostic significance of stromal changes in biopsies of prostate adenocarcinoma. Pathology - Research and Practice, 153436. DOI: 10.1016/j.prp.2021.15343 
5. Semjonov, E.; Minajeva, A.; Dzaparidze, G.; Gvozdkov, A.; Tamp, E. (2020). Patohistoloogilise diagnostika digilahendused Eestis. Eesti Arst, 99 (5), 320−321. 

• Minajeva, Ave; Tamm, Hannes; Mesila, Ingrid; Marandi, Triin (2021). Veebipõhise tiimiõppe võtsid arstiüliõpilased entusiastlikult vastu. Eesti Arst, 100 (5), 323.