Doctoral theses of the Department of Biochemistry

Maria Piirsalu, 2023, (sup) Kersti Lilleväli, Eero Vasar, Mihkel Zilmer. Effects of inflammation and diet on the metabolic profile and selected genetic parameters of Bl6 and 129Sv mouse lines. University of Tartu, Faculty of Medicine.
Liisa Leppik, 2021, (sup) Liina Haring, Eero Vasar, Mihkel Zilmer. Alterations in metabolomic profile of lipids, amino acids and biogenic amines in the early course of schizophrenia spectrum disorders. University of Tartu, Faculty of Medicine.
Teele Kasepalu, (2020), (sup) Jaak Kals, Joel Starkopf, Mihkel Zilmer, Urmas Lepner. Effects of remote ischaemic preconditioning on organ damage and acylcarnitines' metabolism in vascular surgery. University of Tartu, Faculty of Medicine.
Roman Balõtsev, (2020), (sup) Liina Haring, Eero Vasar, Mihkel Zilmer, Kati Koido. Interaction between the immune and metabolic systems in different stages of schizophrenia spectrum disorders. University of Tartu, Faculty of Medicine.
Aigar Ottas, (2019), (sup) Ursel Soomets, Külli Kingo. The metabolomic profiling of psoriasis, atopic dermatitis and atherosclerosis. University of Tartu, Faculty of Medicine.
Rando Porosk, (2019), (sup) Kalle Kilk, Ursel Soomets, Riina Mahlapuu. The role of oxidative stress in Wolfram syndrome 1 and hypothermia. University of Tartu, Faculty of Medicine.
Kärt Kriisa, (2018), (sup) Liina Haring, Mihkel Zilmer, Eero Vasar. Profile of acylcarnitines, inflammation and oxidative stress in first-episode psychosis before and after antipsychotic treatment. University of Tartu, Faculty of Medicine.
Veiko Vengerfeldt, 2018, (sup) Reet Mändar, Tiiu Kullisaar, Mare Saag. Apical periodontitis: prevalence and etiopathogenetic aspects. University of Tartu, Faculty of Medicine.
Kaspar Tootsi, 2017, (sup) Aare Märtson, Jaak Kals, Mihkel Zilmer. Cardiovascular and metabolomic profiling of osteoarthritis. University of Tartu, Faculty of Medicine.
Kaido Paapstel, 2016, (sup) Jaak Kals, Mihkel Zilmer, Jaan Eha. Metabolomic profile of arterial stiffness and early biomarkers of renal damage in atherosclerosis. University of Tartu, Faculty of Medicine.
Hedi Harzia, 2013, (sup) Kalle Kilk, Olav Kärt, Ursel Soomets. Associations between metabolic profile and coagulation ability of bovine milk, effect of feeding and lactation stage (Lehmapiima metaboolse profiili ja laapumise vahelised seosed, söötmise ja laktatsiooniperioodi mõju). Estonian University of Life Sciences.
Erik Salum, 2013, (sup) Mihkel Zilmer, Priit Kampus, Jaak Kals, Jaan Eha. Beneficial effects of vitamin D and angiotensin II receptor blocker on arterial damage. University of Tartu, Faculty of Medicine.
Kairit Joost, 2012, (sup) Ursel Soomets, Katrin Õunap, Riina Zordania, Kalle Kilk. Selective screening of metabolic diseases in Estonia: the application of new diagnostic methods. University of Tartu, Faculty of Medicine.
Martin Serg, 2012, (sup) Jaan Eha, Mihkel Zilmer, Priit Kampus. Therapeutic Aspects of Central Haemodynamics, Arterial Stiffness and Oxidative Stress in Hypertension. University of Tartu, Faculty of Medicine.
Maksim Zagura, 2012, (sup) Mihkel Zilmer, Jaan Eha, Jaak Kals. Biochemical, functional and structural profiling of arterial damage in atherosclerosis. University of Tartu, Faculty of Medicine.
Säde Viirlaid, 2011, (sup) Ursel Soomets, Jaak Järv, Ülo Langel. Novel glutathione analogues and their antioxidant activity University of Tartu, Faculty of Science and Technology.
Tiit Salum, 2011, (sup) Mihkel Zilmer, Eero Vasar. Similarity and difference of temperature-dependence of the brain sodium pump in normal, different neuropathological, and aberrant conditions and its possible reasons. University of Tartu, Faculty of Medicine.
Siim Suutre, 2010, (sup) Andres Arend, Gunnar Selstam, Alar Toom, Mihkel Zilmer. The role of TGF-β isoforms and osteoprogenitor cells in the pathogenesis of heterotopic ossification. An experimental and clinical study of hip arthroplasty University of Tartu, Faculty of Medicine.
Kaire Heilman, 2009, (sup) Mihkel Zilmer, Vallo Tillmann. Risk markers for cardiovascular diseases and low bone mineral density in children with type 1 diabetes. University of Tartu, Faculty of Medicine.
Kersti Ehrlich, 2009, (sup) Mihkel Zilmer, Ursel Soomets. Antioxidative glutathione analogues (UPF peptides) - molecular design, structure-activity relationships and testing protective properties. University of Tartu, Faculty of Medicine.
Kristiina Roots, 2008, (jsup) Mihkel Zilmer, Ello-Rahel Karelson. Cationic regulation of Na-pump in the normal, Alzheimer's and CCK2 receptor-deficient brain.University of Tartu, Faculty of Medicine.
Inga Karu, 2007, (sup) Mihkel Zilmer, Joel Starkopf. Ishaemia-reperfusion injury of the heart during coronary surgery: a clinical study investigating the effect of hyperoxia.University of Tartu, Faculty of Medicine.
Priit Kampus, 2007, (sup) Rein Teesalu, Mihkel Zilmer. Impact of inflammation, oxidative stress and age on arterial stiffness and carotid artery intima-media thickness. University of Tartu, Faculty of Medicine.
Jaak Kals, 2007, (sup) Mihkel Zilmer, Andres Pulges. Endothelial function and arterial stiffness in patients with atherosclerosis and in healthy subjects. University of Tartu, Faculty of Medicine.
Priit Põder, 2006, (sup) Andres Pulges, Mihkel Zilmer. Ursel Soomets. Clinical and experimental investigation: relationship of ischaemia/reperfusion injury with oxidative stress in abdominal aortic aneurysm repair and in extracranial brain artery endarterectomy and possibilities of protection against ischaemia using a glutathione analogue in a rat model of global brain ischaemia. University of Tartu, Faculty of Medicine.
Inga Soveri, 2006, (sup) Mihkel Zilmer. Renal dysfunction and cardiovascular diseases (Neerude düsfunktsioon ja kardiovaskulaarsed haigused). University of Uppsala.
Stanislav Liskmann, 2006, (sup) Mihkel Zilmer, Olev Salum, Tiiu Vihalemm. Peri-implant disease: pathogenesis, diagnosis and treatment in view of both inflammation and oxidative stress profiling. University of Tartu, Faculty of Medicine.
Piibe Muda, 2005, (sup) Rein Teesalu, Mihkel Zilmer. Homocysteine and hypertension: associations between homocysteine and essential hypertension in treated and untreated hypertensive patients with and without coronary artery disease. University of Tartu, Faculty of Medicine.
Aune Rehema, 2004, (sup) Mihkel Zilmer. Assessment of nonhaem ferrous iron and glutathione redox ratio as markers of pathogeneticity of oxidative stress in different clinical groups. University of Tartu, Faculty of Medicine.
Ülle Pechter, 2004, (sup) Mai Rosenberg, Jaak Maaroos, Mihkel Zilmer. Progression Prevention Strategies in Chronic Renal Failure and Hypertension. University of Tartu, Faculty of Medicine.
Riina Mahlapuu, 2004, (sup) Ülo Langel, Mihkel Zilmer. Signalling of galanin and amyloid precursor protein through adenylate cyclase. University of Tartu, Faculty of Medicine.
Maigi Eisen, 2002, (sup) Mihkel Zilmer, Helgi Silm, Sirje Kaur. Pathogenesis of contact dermatitis: participation of oxidative stress: a clinical - biochemical study. University of Tartu, Faculty of Medicine.
Peeter Tähepõld, 2002, (sup) Mihkel Zilmer, Joel Starkopf, Jarle Vaage, Guro Valen. Myocardial protection by hypertension. Karolinska Institutet.
Ursel Soomets, 2000, (sup) Ülo Langel, Mihkel Zilmer. Development of novel transport peptides and their application in antisense techniques. University of Stockholm.
Andres Valkna, 1999, (sup) Ülo Langel, Mihkel Zilmer. Interactions of galanin receptor with ligands and G-proteins: studies with synthetic peptides. University of Tartu, Faculty of Medicine.
Joel Starkopf, 1997, (sup) Mihkel Zilmer. Oxidative stress and ischaemia-reperfusion of the heart: a clinical and experimental study. University of Tartu, Faculty of Medicine.
Triin Parik, 1996, (sup) Mihkel Zilmer, Rein Teesalu. Oxidative stress in essential hypertension: associations with metabolic disturbances and the effects of calcium antagonist treatment. University of Tartu, Faculty of Medicine.

Tartu Ülikooli bio- ja siirdemeditsiini instituudi inimese geneetika õppetooli uuring koostöös Tartu Ülikooli Kliinikumi meestekliinikuga näitas, et üllatavalt suurel osal viljatutest meestest on lapsena diagnoositud munandi laskumishäire. Õigeaegne sekkumine aitab tulevikus lahendada viljatusprobleeme ja ennetada haruldaste kasvajate riski.

Testicular maldescent in infertile men may be a sign of a more severe genetic syndrome

Tartu Ülikool uuring näitas, et ühest geeniveast põhjustatud mehepoolne viljatus on arvatust palju sagedasem.

Doctoral theses of the Department of Biochemistry

Testicular maldescent in infertile men may be a sign of a more severe genetic syndrome

One of the largest male infertility genetic studies improves molecular diagnostics and personalized management of andrology patients

Doctoral defence: Ahto Salumets “Bioinformatics analysis of various aspects in immunology“