research

Publications and patents of the Department of Physiology

  • Friske MM, Torrico EC, Haas MJW, Borruto AM, Giannone F, Hade AC, Yu Y, Gao L, Sutherland GT, Hitzemann R, Philips MA, Fei SS, Sommer WH, Mayfield RD, Spanagel R. A systematic review and meta-analysis on the transcriptomic signatures in alcohol use disorder. Mol Psychiatry. 2025 Jan;30(1):310-326. doi: 10.1038/s41380-024-02719-x. Epub 2024 Sep 6. PMID: 39242950.
  • Jagomäe T, Velling S, Tikva TB, Maksimtšuk V, Gaur N, Reimets R, Kaasik A, Vasar E, Plaas M. GABA and GLP-1 receptor agonist combination therapy modifies diabetes and Langerhans islet cytoarchitecture in a rat model of Wolfram syndrome. Diabetol Metab Syndr. 2025 Mar 6;17(1):82. doi: 10.1186/s13098-025-01651-6. PMID: 40050934.
  • Leidmaa E, Zimmer A, Stein V, Gellner AK. Acute high-fat high-sugar diet rapidly increases blood-brain barrier permeability in mice. J Nutr Health Aging. 2025 Jul;29(7):100574. doi: 10.1016/j.jnha.2025.100574. Epub 2025 May 16. PMID: 40381494.
  • Leidmaa E, Prodan AM, Depner LL, Komorowska-Müller JA, Beins EC, Schuermann B, Kolbe CC, Zimmer A. Astrocytic Dagla deletion decreases hedonic feeding in female mice. Cannabis Cannabinoid Res. 2024 Feb;9(1):74-88. doi: 10.1089/can.2023.0194. Epub 2024 Jan 24. PMID: 38265773.
  • Lavogina D, Krõlov MK, Vellama H, Modhukur V, Di Nisio V, Lust H, Eskla KL, Salumets A, Jaal J. Inhibition of epigenetic and cell cycle-related targets in glioblastoma cell lines reveals that onametostat reduces proliferation and viability in both normoxic and hypoxic conditions. Sci Rep. 2024 Feb 21;14(1):4303. doi: 10.1038/s41598-024-54707-4. PMID: 38383756; PMCID: PMC10881536.
  • Traks T, Reemann P, Eskla KL, Ottas A, Jagomäe T, Liira R, Ilves L, Jaks V, Raam L, Abram K, Kingo K. High-throughput proteomic analysis of chronic inflammatory skin diseases: Psoriasis and atopic dermatitis. Exp Dermatol. 2024 Apr;33(4):e15079. doi: 10.1111/exd.15079. PMID: 38654506.
  • Hade AC, Philips MA, Promet L, Jagomäe T, Hanumantharaju A, Salumäe L, Reimann E, Plaas M, Vasar E, Väli M. A cost-effective and efficient ex vivo, ex situ human whole brain perfusion protocol for immunohistochemistry. J Neurosci Methods. 2024;404:110059. doi: 10.1016/j.jneumeth.2024.110059. PMID: 39528266.
  • Singh K, Jayaram M, Hanumantharaju A, Tõnissoo T, Jagomäe T, Mikheim K, Muthuraman S, Gilbert SF, Plaas M, Schäfer MKE, Innos J, Lilleväli K, Philips MA, Vasar E. The IgLON family of cell adhesion molecules expressed in developing neural circuits ensure the proper functioning of the sensory system in mice. Sci Rep. 2024;14:22593. doi: 10.1038/s41598-024-73358-z. PMID: 39522133.
  • Liiv M, Vaarmann A, Safiulina D, Choubey V, Gupta R, Kuum M, Janickova L, Hodurova Z, Cagalinec M, Zeb A, Hickey MA, Huang YL, Gogichaishvili N, Mandel M, Plaas M, Vasar E, Loncke J, Vervliet T, Tsai TF, Bultynck G, Veksler V, Kaasik A. ER calcium depletion as a key driver for impaired ER-to-mitochondria calcium transfer and mitochondrial dysfunction in Wolfram syndrome. Nat Commun. 2024 Jul 21;15(1):6143. doi: 10.1038/s41467-024-50502-x. PMID: 39034309; PMCID: PMC11133503.
  • Tulva K, Pirajev A, Zeb A, Aksoy AE, Bello A, Lee B, Guðjónsson BF, Helgadottir SB, Jagomäe T, García-Llorca A, Eysteinsson T, Jürgenson M, Plaas M, Vasar E, Kaasik A, Hickey MA. Early trigeminal and sensory impairment and lysosomal dysfunction in accurate models of Wolfram syndrome. Exp Neurol. 2025 Mar;385:115099. doi: 10.1016/j.expneurol.2024.115099. Epub 2024 Dec 9. PMID: 39662795.
  • Heinla K, Vasar E, Reppo I, Sedman T, Volke V. GLP-1 receptor agonists induce growth hormone secretion in healthy volunteers. Diabetes Ther. 2023 Apr;14(4):777-786. doi: 10.1007/s13300-023-01381-w. Epub 2023 Feb 17. PMID: 36800161.
  • Punapart M, Reimets R, Seppa K, Kirillov S, Gaur N, Eskla KL, Jagomäe T, Vasar E, Plaas M. Chronic Stress Alters Hippocampal Renin-Angiotensin-Aldosterone System Component Expression in an Aged Rat Model of Wolfram Syndrome. Genes (Basel). 2023 Mar 30;14(4):827. doi: 10.3390/genes14040827. PMID: 37107585; PMCID: PMC10137641.
  • Kuuskmäe C, Philips MA, Kilk K, Haring L, Kangro R, Seppo I, Zilmer M, Vasar E. Kynurenine pathway dynamics in patients with schizophrenia spectrum disorders across the disease trajectory. Psychiatry Res. 2023;328:115423. doi: 10.1016/j.psychres.2023.115423.
  • Korhonen L, Paul ER, Wåhlén K, Haring L, Vasar E, Vaheri A, Lindholm D. Multivariate analyses of immune markers reveal increases in plasma EN-RAGE in first-episode psychosis patients. Transl Psychiatry. 2023 Oct 20;13(1):326. doi: 10.1038/s41398-023-02627-8. PMID: 37863883.
  • Jagomäe T, Gaur N, Seppa K, Reimets R, Pastak M, Plaas M, Kaasik A, Vasar E, Plaas M. Treatment with the dual-incretin agonist DA-CH5 demonstrates potent therapeutic effect in a rat model of Wolfram syndrome. Front Endocrinol (Lausanne). 2023 Oct 13;14:1234925. doi: 10.3389/fendo.2023.1234925. PMID: 37901050; PMCID: PMC10616884.
  • Vera-Siguenza E, Escribano-Gonzalez C, Serrano-Gonzalo I, Eskla KL, Spill F, Tennant D. Mathematical reconstruction of the metabolic network in an in-vitro multiple myeloma model. PLoS Comput Biol. 2023 Sep 15;19(9):e1011374. doi: 10.1371/journal.pcbi.1011374. PMID: 37713666; PMCID: PMC10503963.
  • Vellama H, Eskla KL, Eichelmann H, Hüva A, Tennant DA, Thakker A, Roberts J, Jagomäe T, Porosk R, Laisk A, Oja V, Rämma H, Volke V, Vasar E, Luuk H. VHL-deficiency leads to reductive stress in renal cells. Free Radic Biol Med. 2023 Nov 1;208:1-12. doi: 10.1016/j.freeradbiomed.2023.07.029. Epub 2023 Jul 26. PMID: 37506952; PMCID: PMC10602395.
  • Westbrook RL, Bridges E, Roberts J, Escribano-Gonzalez C, Eales KL, Vettore LA, Walker PD, Vera-Siguenza E, Rana H, Cuozzo F, Eskla KL, Vellama H, Shaaban A, Nixon C, Luuk H, Lavery GG, Hodson DJ, Harris AL, Tennant DA. Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions. Cell Rep. 2022 Feb 1;38(5):110320. doi: 10.1016/j.celrep.2022.110320. PMID: 35108535; PMCID: PMC8822494.
  • Lavogina D, Lust H, Tahk MJ, Laasfeld T, Vellama H, Nasirova N, Vardja M, Eskla KL, Salumets A, Rinken A, Jaal J. Revisiting the Resazurin-Based Sensing of Cellular Viability: Widening the Application Horizon. Biosensors (Basel). 2022 Mar 25;12(4):196. doi: 10.3390/bios12040196. PMID: 35448256; PMCID: PMC9032648.
  • Piirsalu M, Chithanathan K, Jayaram M, Visnapuu T, Lilleväli K, Zilmer M, Vasar E. Lipopolysaccharide-induced strain-specific differences in neuroinflammation and MHC-I pathway regulation in the brains of Bl6 and 129Sv mice. Cells. 2022 Mar 18;11(6):1032. doi: 10.3390/cells11061032. PMID: 35326484.
  • Eskla KL, Vellama H, Tarve L, Eichelmann H, Jagomäe T, Porosk R, Oja V, Rämma H, Peet N, Laisk A, Volke V, Vasar E, Luuk H. Hypothermia alleviates reductive stress, a root cause of ischemia reperfusion injury. Int J Mol Sci. 2022 Sep 3;23(17):10108. doi: 10.3390/ijms231710108. PMID: 36077504; PMCID: PMC9456258.
  • Piirsalu M, Taalberg E, Jayaram M, Lilleväli K, Zilmer M, Vasar E. Impact of a high-fat diet on the metabolomics profile of 129S6 and C57BL6 mouse strains. Int J Mol Sci. 2022 Oct 2;23(19):11682. doi: 10.3390/ijms231911682. PMID: 36232982.
  • Jaago M, Rähni A, Pupina N, Pihlak A, Sadam H, Tuvikene J, Avarlaid A, Planken A, Planken M, Haring L, Vasar E, Baćević M, Lambert F, Kalso E, Pussinen P, Tienari PJ, Vaheri A, Lindholm D, Timmusk T, Ghaemmaghami AM, Palm K. Differential patterns of cross-reactive antibody response against SARS-CoV-2 spike protein detected for chronically ill and healthy COVID-19 naïve individuals. Sci Rep. 2022 Oct 7;12(1):16817. doi: 10.1038/s41598-022-20849-6. PMID: 36207326.
  • Parksepp M, Haring L, Kilk K, Taalberg E, Kangro R, Zilmer M, Vasar E. A marked low-grade inflammation and a significant deterioration in metabolic status in first-episode schizophrenia: a five-year follow-up study. Metabolites. 2022 Oct 17;12(10):983. doi: 10.3390/metabo12100983. PMID: 36295885.
  • Kaare M, Jayaram M, Jagomäe T, Singh K, Kilk K, Mikheim K, Leevik M, Leidmaa E, Varul J, Nõmm H, Rähn K, Visnapuu T, Plaas M, Lilleväli K, Schäfer MKE, Philips MA, Vasar E. Depression-associated Negr1 gene-deficiency induces alterations in the monoaminergic neurotransmission enhancing time-dependent sensitization to amphetamine in male mice. Brain Sci. 2022 Dec 10;12(12):1696. doi: 10.3390/brainsci12121696. PMID: 36552158.
  • Parksepp M, Haring L, Kilk K, Koch K, Uppin K, Kangro R, Zilmer M, Vasar E. The expanded endocannabinoid system contributes to metabolic and body mass shifts in first-episode schizophrenia: a 5-year follow-up study. Biomedicines. 2022 Jan 24;10(2):243. doi: 10.3390/biomedicines10020243. PMID: 35203453.
  • Loite U, Raam L, Reimann E, Reemann P, Prans E, Traks T, Vasar E, Silm H, Kingo K, Kõks S. The Expression Pattern of Genes Related to Melanogenesis and Endogenous Opioids in Psoriasis. Int J Mol Sci. 2021 Dec 2;22(23):13056. doi: 10.3390/ijms222313056. PMID: 34884858; PMCID: PMC8657874.
  • Jagomäe T, Seppa K, Reimets R, Pastak M, Plaas M, Hickey MA, Kukker KG, Moons L, De Groef L, Vasar E, Kaasik A, Terasmaa A, Plaas M. Early Intervention and Lifelong Treatment with GLP1 Receptor Agonist Liraglutide in a Wolfram Syndrome Rat Model with an Emphasis on Visual Neurodegeneration, Sensorineural Hearing Loss and Diabetic Phenotype. Cells. 2021 Nov 16;10(11):3193. doi: 10.3390/cells10113193. PMID: 34831417; PMCID: PMC8623088.
  • Punapart M, Seppa K, Jagomäe T, Liiv M, Reimets R, Kirillov S, Kaasik A, Moons L, De Groef L, Terasmaa A, Vasar E, Plaas M. The Expression of RAAS Key Receptors, Agtr2 and Bdkrb1, Is Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome. Genes (Basel). 2021 Oct 28;12(11):1717. doi: 10.3390/genes12111717. PMID: 34828323; PMCID: PMC8621801.
  • Kaare M, Mikheim K, Lilleväli K, Kilk K, Jagomäe T, Leidmaa E, Piirsalu M, Porosk R, Singh K, Reimets R, Taalberg E, Schäfer MKE, Plaas M, Vasar E, Philips MA. High-Fat Diet Induces Pre-Diabetes and Distinct Sex-Specific Metabolic Alterations in Negr1-Deficient Mice. Biomedicines. 2021 Sep 3;9(9):1148. doi: 10.3390/biomedicines9091148. PMID: 34572334; PMCID: PMC8466019.
  • Yan L, Gu MQ, Yang ZY, Xia J, Li P, Vasar E, Tian L, Song C. Endogenous n-3 PUFAs attenuated olfactory bulbectomy-induced behavioral and metabolomic abnormalities in Fat-1 mice. Brain Behav Immun. 2021 Aug;96:143-153. doi: 10.1016/j.bbi.2021.05.024. Epub 2021 May 27. PMID: 34052364.
  • Jagomäe T, Singh K, Philips MA, Jayaram M, Seppa K, Tekko T, Gilbert SF, Vasar E, Lilleväli K. Alternative Promoter Use Governs the Expression of IgLON Cell Adhesion Molecules in Histogenetic Fields of the Embryonic Mouse Brain. Int J Mol Sci. 2021 Jun 28;22(13):6955. doi: 10.3390/ijms22136955. PMID: 34203377; PMCID: PMC8268470.
  • Heinla K, Vasar E, Sedman T, Volke V. A GLP-1 Receptor Agonist Inhibits Aldosterone Release in Healthy Volunteers. Horm Metab Res. 2021 Jun;53(6):402-407. doi: 10.1055/a-1498-7098. Epub 2021 Jun 21. PMID: 34154031.
  • Varul J, Eskla KL, Piirsalu M, Innos J, Philips MA, Visnapuu T, Plaas M, Vasar E. Dopamine System, NMDA Receptor and EGF Family Expressions in Brain Structures of Bl6 and 129Sv Strains Displaying Different Behavioral Adaptation. Brain Sci. 2021 May 29;11(6):725. doi: 10.3390/brainsci11060725. PMID: 34072341; PMCID: PMC8227283.
  • Hade AC, Philips MA, Reimann E, Jagomäe T, Eskla KL, Traks T, Prans E, Kõks S, Vasar E, Väli M. Chronic Alcohol Use Induces Molecular Genetic Changes in the Dorsomedial Thalamus of People with Alcohol-Related Disorders. Brain Sci. 2021 Mar 29;11(4):435. doi: 10.3390/brainsci11040435. PMID: 33805312; PMCID: PMC8066746.
  • Vanaveski T, Molchanova S, Pham DD, Schäfer A, Pajanoja C, Narvik J, Srinivasan V, Urb M, Koivisto M, Vasar E, Timmusk T, Minkeviciene R, Eriksson O, Lalowski M, Taira T, Korhonen L, Voikar V, Lindholm D. PGC-1α Signaling Increases GABA(A) Receptor Subunit α2 Expression, GABAergic Neurotransmission and Anxiety-Like Behavior in Mice. Front Mol Neurosci. 2021 Feb 1;14:588230. doi: 10.3389/fnmol.2021.588230. PMID: 33597848; PMCID: PMC7882546.
  • Seppa K, Jagomäe T, Kukker KG, Reimets R, Pastak M, Vasar E, Terasmaa A, Plaas M. Liraglutide, 7,8-DHF and their co-treatment prevents loss of vision and cognitive decline in a Wolfram syndrome rat model. Sci Rep. 2021 Jan 26;11(1):2275. doi: 10.1038/s41598-021-81768-6. PMID: 33500541; PMCID: PMC7838169.
  • Bregin A, Kaare M, Jagomäe T, Karis K, Singh K, Laugus K, Innos J, Leidmaa E, Heinla I, Visnapuu T, Oja EM, Kõiv K, Lilleväli K, Harro J, Philips MA, Vasar E. Expression and impact of Lsamp neural adhesion molecule in the serotonergic neurotransmission system. Pharmacol Biochem Behav. 2020 Nov;198:173017. doi: 10.1016/j.pbb.2020.173017. Epub 2020 Aug 20. PMID: 32828972.
  • Sedman T, Krass M, Rünkorg K, Vasar E, Volke V. Tolerance develops toward GLP-1 receptor agonists' glucose-lowering effect in mice. Eur J Pharmacol. 2020 Oct 15;885:173443. doi: 10.1016/j.ejphar.2020.173443. Epub 2020 Aug 1. PMID: 32750365.
  • Parksepp M, Leppik L, Koch K, Uppin K, Kangro R, Haring L, Vasar E, Zilmer M. Metabolomics approach revealed robust changes in amino acid and biogenic amine signatures in patients with schizophrenia in the early course of the disease. Sci Rep. 2020 Aug 19;10(1):13983. doi: 10.1038/s41598-020-71014-w. PMID: 32814830; PMCID: PMC7438522.
  • Piirsalu M, Taalberg E, Lilleväli K, Tian L, Zilmer M, Vasar E. Treatment With Lipopolysaccharide Induces Distinct Changes in Metabolite Profile and Body Weight in 129Sv and Bl6 Mouse Strains. Front Pharmacol. 2020 Mar 27;11:371. doi: 10.3389/fphar.2020.00371. PMID: 32292347; PMCID: PMC7118216.
  • Leppik L, Parksepp M, Janno S, Koido K, Haring L, Vasar E, Zilmer M. Profiling of lipidomics before and after antipsychotic treatment in first- episode psychosis. Eur Arch Psychiatry Clin Neurosci. 2020 Feb;270(1):59-70. doi: 10.1007/s00406-018-0971-6. Epub 2019 Jan 2. PMID: 30604052.
  • Seppa K, Toots M, Reimets R, Jagomäe T, Koppel T, Pallase M, Hasselholt S, Krogsbæk Mikkelsen M, Randel Nyengaard J, Vasar E, Terasmaa A, Plaas M. GLP-1 receptor agonist liraglutide has a neuroprotective effect on an aged rat model of Wolfram syndrome. Sci Rep. 2019 Oct 31;9(1):15742. doi: 10.1038/s41598-019-52295-2. PMID: 31673100; PMCID: PMC6823542.
  • Bregin A, Mazitov T, Aug I, Philips MA, Innos J, Vasar E. Increased sensitivity to psychostimulants and GABAergic drugs in Lsamp-deficient mice. Pharmacol Biochem Behav. 2019 Aug;183:87-97. doi: 10.1016/j.pbb.2019.05.010. Epub 2019 Jun 1. PMID: 31163180.
  • Singh K, Jayaram M, Kaare M, Leidmaa E, Jagomäe T, Heinla I, Hickey MA, Kaasik A, Schäfer MK, Innos J, Lilleväli K, Philips MA, Vasar E. Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders. Sci Rep. 2019 Apr 1;9(1):5457. doi: 10.1038/s41598-019-41991-8. PMID: 30932003; PMCID: PMC6443666.
  • Demin KA, Sysoev M, Chernysh MV, Savva AK, Koshiba M, Wappler-Guzzetta EA, Song C, De Abreu MS, Leonard B, Parker MO, Harvey BH, Tian L, Vasar E, Strekalova T, Amstislavskaya TG, Volgin AD, Alpyshov ET, Wang D, Kalueff AV. Animal models of major depressive disorder and the implications for drug discovery and development. Expert Opin Drug Discov. 2019 Apr;14(4):365-378. doi: 10.1080/17460441.2019.1575360. Epub 2019 Feb 22. PMID: 30793996.
  • Traks T, Keermann M, Karelson M, Rätsep R, Reimann E, Silm H, Vasar E, Kõks S, Kingo K. Polymorphisms in Corticotrophin-releasing Hormone- proopiomelanocortin (CRH-POMC) System Genes are Associated with Plaque Psoriasis. Acta Derm Venereol. 2019 Apr 1;99(4):444-445. doi: 10.2340/00015555-3137. PMID: 30723871.
  • Toots M, Reimets R, Plaas M, Vasar E. Muscarinic Agonist Ameliorates Insulin Secretion in Wfs1-Deficient Mice. Can J Diabetes. 2019 Mar;43(2):115-120. doi: 10.1016/j.jcjd.2018.06.007. Epub 2018 Jun 23. PMID: 30266217.
  • Balõtšev R, Haring L, Koido K, Leping V, Kriisa K, Zilmer M, Vasar V, Piir A, Lang A, Vasar E. Antipsychotic treatment is associated with inflammatory and metabolic biomarkers alterations among first-episode psychosis patients: A 7-month follow-up study. Early Interv Psychiatry. 2019 Feb;13(1):101-109. doi: 10.1111/eip.12457. Epub 2017 Jul 18. PMID: 28719155.
  • Toots M, Seppa K, Jagomäe T, Koppel T, Pallase M, Heinla I, Terasmaa A, Plaas M, Vasar E. Preventive treatment with liraglutide protects against development of glucose intolerance in a rat model of Wolfram syndrome. Sci Rep. 2018 Jul 5;8(1):10183. doi: 10.1038/s41598-018-28314-z. PMID: 29976929; PMCID:PMC6033861.
  • Vanaveski T, Narvik J, Innos J, Philips MA, Ottas A, Plaas M, Haring L, Zilmer M, Vasar E. Repeated Administration of D-Amphetamine Induces Distinct Alterations in Behavior and Metabolite Levels in 129Sv and Bl6 Mouse Strains. Front Neurosci. 2018 Jun 12;12:399. doi: 10.3389/fnins.2018.00399. PMID: 29946233; PMCID: PMC6005828.
  • Eskla KL, Porosk R, Reimets R, Visnapuu T, Vasar E, Hundahl CA, Luuk H. Hypothermia augments stress response in mammalian cells. Free Radic Biol Med. 2018 Jun;121:157-168. doi: 10.1016/j.freeradbiomed.2018.04.571. Epub 2018 Apr 25. PMID: 29704622.
  • Singh K, Lilleväli K, Gilbert SF, Bregin A, Narvik J, Jayaram M, Rahi M, Innos J, Kaasik A, Vasar E, Philips MA. The combined impact of IgLON family proteins Lsamp and Neurotrimin on developing neurons and behavioral profiles in mouse. Brain Res Bull. 2018 Jun;140:5-18. doi: 10.1016/j.brainresbull.2018.03.013. Epub 2018 Mar 29. PMID: 29605488.
  • Heinla I, Åhlgren J, Vasar E, Voikar V. Behavioural characterization of C57BL/6N and BALB/c female mice in social home cage - Effect of mixed housing in complex environment. Physiol Behav. 2018 May 1;188:32-41. doi: 10.1016/j.physbeh.2018.01.024. Epub 2018 Jan 31. PMID: 29382562.
  • Leppik L, Kriisa K, Koido K, Koch K, Kajalaid K, Haring L, Vasar E, Zilmer M. Profiling of Amino Acids and Their Derivatives Biogenic Amines Before and After Antipsychotic Treatment in First-Episode Psychosis. Front Psychiatry. 2018 Apr 24;9:155. doi: 10.3389/fpsyt.2018.00155. PMID: 29740359; PMCID: PMC5928450.
  • Narvik J, Vanaveski T, Innos J, Philips MA, Ottas A, Haring L, Zilmer M, Vasar E. Metabolic profile associated with distinct behavioral coping strategies of 129Sv and Bl6 mice in repeated motility test. Sci Rep. 2018 Feb 21;8(1):3405. doi: 10.1038/s41598-018-21752-9. PMID: 29467440; PMCID: PMC5821849.
  • Singh K, Loreth D, Pöttker B, Hefti K, Innos J, Schwald K, Hengstler H, Menzel L, Sommer CJ, Radyushkin K, Kretz O, Philips MA, Haas CA, Frauenknecht K, Lilleväli K, Heimrich B, Vasar E, Schäfer MKE. Neuronal Growth and Behavioral Alterations in Mice Deficient for the Psychiatric Disease-Associated Negr1 Gene. Front Mol Neurosci. 2018 Feb 9;11:30. doi: 10.3389/fnmol.2018.00030. PMID: 29479305; PMCID: PMC5811522.
  • Karis K, Eskla KL, Kaare M, Täht K, Tuusov J, Visnapuu T, Innos J, Jayaram M, Timmusk T, Weickert CS, Väli M, Vasar E, Philips MA. Altered Expression Profile of IgLON Family of Neural Cell Adhesion Molecules in the Dorsolateral Prefrontal Cortex of Schizophrenic Patients. Front Mol Neurosci. 2018 Jan 29;11:8. doi: 10.3389/fnmol.2018.00008. PMID: 29434535; PMCID: PMC5797424.
  • Kriisa K, Leppik L, Balõtšev R, Ottas A, Soomets U, Koido K, Volke V, Innos J, Haring L, Vasar E, Zilmer M. Profiling of Acylcarnitines in First Episode Psychosis before and after Antipsychotic Treatment. J Proteome Res. 2017 Oct 6;16(10):3558-3566. doi: 10.1021/acs.jproteome.7b00279. Epub 2017 Aug 24. PMID: 28786289.
  • Plaas M, Seppa K, Reimets R, Jagomäe T, Toots M, Koppel T, Vallisoo T, Nigul M, Heinla I, Meier R, Kaasik A, Piirsoo A, Hickey MA, Terasmaa A, Vasar E. Wfs1- deficient rats develop primary symptoms of Wolfram syndrome: insulin-dependent diabetes, optic nerve atrophy and medullary degeneration. Sci Rep. 2017 Aug 31;7(1):10220. doi: 10.1038/s41598-017-09392-x. PMID: 28860598; PMCID: PMC5579261.
  • Sedman T, Vasar E, Volke V. Tolerance Does Not Develop Toward Liraglutide's Glucose-Lowering Effect. J Clin Endocrinol Metab. 2017 Jul 1;102(7):2335-2339. doi: 10.1210/jc.2017-00199. PMID: 28379427.
  • Haring L, Mõttus R, Kajalaid K, Koch K, Uppin K, Maron E, Vasar E. The course of cognitive functioning after first-episode of psychosis: A six month follow-up study. Schizophr Res. 2017 Apr;182:31-41. doi: 10.1016/j.schres.2016.10.017. Epub 2016 Oct 13. PMID: 27746055.
  • Reemann P, Reimann E, Ilmjärv S, Porosaar O, Silm H, Jaks V, Vasar E, Kingo K, Kõks S. Correction: Melanocytes in the Skin - Comparative Whole Transcriptome Analysis of Main Skin Cell Types. PLoS One. 2017 Mar 7;12(3):e0173792. doi: 10.1371/journal.pone.0173792. Erratum for: PLoS One. 2014 Dec 29;9(12):e115717. PMID: 28267805; PMCID: PMC5340379.
  • Tekko T, Lakspere T, Allikalt A, End J, Kõlvart KR, Jagomäe T, Terasmaa A, Philips MA, Visnapuu T, Väärtnõu F, Gilbert SF, Rinken A, Vasar E, Lilleväli K. Wfs1 is expressed in dopaminoceptive regions of the amniote brain and modulates levels of D1-like receptors. PLoS One. 2017 Mar 7;12(3):e0172825. doi: 10.1371/journal.pone.0172825. PMID: 28267787; PMCID: PMC5436468.
  • Vanaveski T, Singh K, Narvik J, Eskla KL, Visnapuu T, Heinla I, Jayaram M, Innos J, Lilleväli K, Philips MA, Vasar E. Promoter-Specific Expression and Genomic Structure of IgLON Family Genes in Mouse. Front Neurosci. 2017 Feb 2;11:38. doi: 10.3389/fnins.2017.00038. PMID: 28210208; PMCID: PMC5288359.
  • Transgenic animal model for modelling pathological anxiety, a method for identifying compounds for treatment of diseases or disorders caused by pathological anxiety and a method for using wfsl protein as a target for identifying effective compounds against pathological anxiety; Owners: University of Tartu; Authors: Eero Vasar, Sulev Kõks, Hendrik Luuk, Sirli Raud, Mario Plaas; Priority number: P200600039; Priority date: 12.12.2006.